Strain Differences in Sensitivity to the Promoting Effect of Sodium L‐Ascorbate in a Two‐stage Rat Urinary Bladder Carcinogenesis Model

Rat strain differences in sensitivity to the promoting effect of sodium L‐ascorbate (SA) on the development of urinary bladder tumors were investigated. In experiment 1, WS/Shi (WS), ODS/Shi‐od/od (ODS), and LEW/Crj (LEW) rats were initiated with 0.05%N‐butyl‐N‐(4‐hydroxybutyl)‐nitrosamine (BBN) in...

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Veröffentlicht in:	Cancer science 1997-03, Vol.88 (3), p.245-253
Hauptverfasser:	Murai, Takashi, Mori, Satoru, Hosono, Motoko, Takashima, Akira, Machine, Setsuko, Oohara, Tadao, Yamashita, Hirofumi, Makino, Susumu, Matsuda, Tsutomu, Wanibuchi, Hideki, Fukushima, Shoji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ascorbic acid Ascorbic Acid - toxicity Biological and medical sciences Bladder Body Weight - drug effects Butylhydroxybutylnitrosamine - administration & dosage Butylhydroxybutylnitrosamine - toxicity Carcinogenesis Carcinogenesis, carcinogens and anticarcinogens Carcinogens - administration & dosage Carcinogens - toxicity Chemical agents Diet Drinking water Experiments Genetic factors Globulins Male Medical sciences ODS/Shi‐od/od rat Organ Size - drug effects Organic acids Rats Rats, Inbred Lew Rats, Inbred Strains Renal tubules Rodents Salts Sodium Sodium L‐ascorbate Species Specificity Survival Rate Tumorigenesis Tumors Urinary bladder Urinary Bladder - anatomy & histology Urinary Bladder - drug effects Urinary Bladder - pathology Urinary bladder carcino‐genesis Urinary Bladder Neoplasms - chemically induced Urinary Bladder Neoplasms - pathology Water Supply Western blotting WS/Shi rat α2u‐globulin
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