Development of Aberrant Crypt Foci Involves a Fission Mechanism as Revealed by Isolation of Aberrant Crypts
Morphological analysis of isolated colonic crypts in rats, postnatally, indicated that the crypts reproduce themselves by a fission mechanism, the division beginning at the crypt base and proceeding upwards until there are two separate crypts. Occasionally, before the separation is complete, a secon...
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| Veröffentlicht in: | Cancer science 1996-12, Vol.87 (12), p.1199-1203 |
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| container_title | Cancer science |
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| creator | Fujimitsu, Yasunobu Nakanishi, Hayao Inada, Ken‐ichi Yamachika, Takasuke Ichinose, Masutaro Fukami, Hiroko Tatematsu, Masae |
| description | Morphological analysis of isolated colonic crypts in rats, postnatally, indicated that the crypts reproduce themselves by a fission mechanism, the division beginning at the crypt base and proceeding upwards until there are two separate crypts. Occasionally, before the separation is complete, a second fission process starts on one or both sides of a bifurcating crypt and a triple‐branched or quadruple‐branched crypt results. Analysis of isolated aberrant crypt foci (ACF) in rats treated with 1,2‐dimethylhydrazine revealed that the development of ACF consisting of multiple crypts is also due to a fission mechanism. Initially, an indentation appears at the base of a single ACF crypt, with subsequent formation of a bifurcation and eventual crypt division. |
| doi_str_mv | 10.1111/j.1349-7006.1996.tb03133.x |
| format | Article |
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Occasionally, before the separation is complete, a second fission process starts on one or both sides of a bifurcating crypt and a triple‐branched or quadruple‐branched crypt results. Analysis of isolated aberrant crypt foci (ACF) in rats treated with 1,2‐dimethylhydrazine revealed that the development of ACF consisting of multiple crypts is also due to a fission mechanism. Initially, an indentation appears at the base of a single ACF crypt, with subsequent formation of a bifurcation and eventual crypt division.</description><identifier>ISSN: 0910-5050</identifier><identifier>ISSN: 1347-9032</identifier><identifier>EISSN: 1349-7006</identifier><identifier>EISSN: 1876-4673</identifier><identifier>DOI: 10.1111/j.1349-7006.1996.tb03133.x</identifier><identifier>PMID: 9045953</identifier><identifier>CODEN: GANNA2</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>1,2-Dimethylhydrazine ; Aberrant crypt foci ; Animal tumors. Experimental tumors ; Animals ; Biological and medical sciences ; Colon ; Colon - drug effects ; Colon - pathology ; Colon - ultrastructure ; Crypt isolation technique ; Dimethylhydrazines - pharmacology ; Experimental digestive system and abdominal tumors ; Fission mechanism ; Medical sciences ; Microscopy, Electron, Scanning ; Mutagens - pharmacology ; Rats ; Rats, Inbred F344 ; Tumors</subject><ispartof>Cancer science, 1996-12, Vol.87 (12), p.1199-1203</ispartof><rights>1997 INIST-CNRS</rights><rights>Copyright John Wiley & Sons, Inc. 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Occasionally, before the separation is complete, a second fission process starts on one or both sides of a bifurcating crypt and a triple‐branched or quadruple‐branched crypt results. Analysis of isolated aberrant crypt foci (ACF) in rats treated with 1,2‐dimethylhydrazine revealed that the development of ACF consisting of multiple crypts is also due to a fission mechanism. Initially, an indentation appears at the base of a single ACF crypt, with subsequent formation of a bifurcation and eventual crypt division.</description><subject>1,2-Dimethylhydrazine</subject><subject>Aberrant crypt foci</subject><subject>Animal tumors. Experimental tumors</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Colon</subject><subject>Colon - drug effects</subject><subject>Colon - pathology</subject><subject>Colon - ultrastructure</subject><subject>Crypt isolation technique</subject><subject>Dimethylhydrazines - pharmacology</subject><subject>Experimental digestive system and abdominal tumors</subject><subject>Fission mechanism</subject><subject>Medical sciences</subject><subject>Microscopy, Electron, Scanning</subject><subject>Mutagens - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Tumors</subject><issn>0910-5050</issn><issn>1347-9032</issn><issn>1349-7006</issn><issn>1876-4673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqVkVGPEyEUhYnRrHX1J5gQ9XXGCwwM-KBp6labrDEx-kyAYdyp06HCtG7_vUw6aTQ-yQuEc-65Fz6EXhAoSV6vtyVhlSpqAFESpUQ5WmCEsfL-AVpcpIdoAYpAwYHDY_QkpS0AqUHQK3SloOKKswX68d4ffR_2Oz-MOLR4aX2MJp9X8bQf8Tq4Dm-GY-iPPmGD111KXRjwJ-_uzNClHTYJf8kRpvcNtie8SaE342T5Jyw9RY9a0yf_bN6v0bf1zdfVx-L284fNanlbOEGVKoyXQJxvWk-VsIZ6x4QUjKq6trXjlkppVG0ryTmlVjZMVlKAb23DlWgJZ9fo7Tl3f7A737j8tGh6vY_dzsSTDqbTfytDd6e_h6PmihJgkANezgEx_Dz4NOptOMQhz6wpUyr3Bc6y683Z5WJIKfr20oGAnjjprZ5g6AmGnjjpmZO-z8XP_5zxUjqDyfqrWTfJmb7N3-i6dLFRXleS0Gx7d7b96np_-o8B9Gp5Q_IV-w2tlrDK</recordid><startdate>199612</startdate><enddate>199612</enddate><creator>Fujimitsu, Yasunobu</creator><creator>Nakanishi, Hayao</creator><creator>Inada, Ken‐ichi</creator><creator>Yamachika, Takasuke</creator><creator>Ichinose, Masutaro</creator><creator>Fukami, Hiroko</creator><creator>Tatematsu, Masae</creator><general>Blackwell Publishing Ltd</general><general>Japanese Cancer Association</general><general>John Wiley & Sons, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>199612</creationdate><title>Development of Aberrant Crypt Foci Involves a Fission Mechanism as Revealed by Isolation of Aberrant Crypts</title><author>Fujimitsu, Yasunobu ; Nakanishi, Hayao ; Inada, Ken‐ichi ; Yamachika, Takasuke ; Ichinose, Masutaro ; Fukami, Hiroko ; Tatematsu, Masae</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6299-ae801cedfe296ba2ec368632977b7c5b288a97b485522b8d384860efbd596f153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>1,2-Dimethylhydrazine</topic><topic>Aberrant crypt foci</topic><topic>Animal tumors. Experimental tumors</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Colon</topic><topic>Colon - drug effects</topic><topic>Colon - pathology</topic><topic>Colon - ultrastructure</topic><topic>Crypt isolation technique</topic><topic>Dimethylhydrazines - pharmacology</topic><topic>Experimental digestive system and abdominal tumors</topic><topic>Fission mechanism</topic><topic>Medical sciences</topic><topic>Microscopy, Electron, Scanning</topic><topic>Mutagens - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fujimitsu, Yasunobu</creatorcontrib><creatorcontrib>Nakanishi, Hayao</creatorcontrib><creatorcontrib>Inada, Ken‐ichi</creatorcontrib><creatorcontrib>Yamachika, Takasuke</creatorcontrib><creatorcontrib>Ichinose, Masutaro</creatorcontrib><creatorcontrib>Fukami, Hiroko</creatorcontrib><creatorcontrib>Tatematsu, Masae</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fujimitsu, Yasunobu</au><au>Nakanishi, Hayao</au><au>Inada, Ken‐ichi</au><au>Yamachika, Takasuke</au><au>Ichinose, Masutaro</au><au>Fukami, Hiroko</au><au>Tatematsu, Masae</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of Aberrant Crypt Foci Involves a Fission Mechanism as Revealed by Isolation of Aberrant Crypts</atitle><jtitle>Cancer science</jtitle><addtitle>Jpn J Cancer Res</addtitle><date>1996-12</date><risdate>1996</risdate><volume>87</volume><issue>12</issue><spage>1199</spage><epage>1203</epage><pages>1199-1203</pages><issn>0910-5050</issn><issn>1347-9032</issn><eissn>1349-7006</eissn><eissn>1876-4673</eissn><coden>GANNA2</coden><abstract>Morphological analysis of isolated colonic crypts in rats, postnatally, indicated that the crypts reproduce themselves by a fission mechanism, the division beginning at the crypt base and proceeding upwards until there are two separate crypts. Occasionally, before the separation is complete, a second fission process starts on one or both sides of a bifurcating crypt and a triple‐branched or quadruple‐branched crypt results. Analysis of isolated aberrant crypt foci (ACF) in rats treated with 1,2‐dimethylhydrazine revealed that the development of ACF consisting of multiple crypts is also due to a fission mechanism. Initially, an indentation appears at the base of a single ACF crypt, with subsequent formation of a bifurcation and eventual crypt division.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>9045953</pmid><doi>10.1111/j.1349-7006.1996.tb03133.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cancer science, 1996-12, Vol.87 (12), p.1199-1203 |
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| language | eng |
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| source | MEDLINE; Wiley Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; IngentaConnect Free/Open Access Journals; PubMed Central |
| subjects | 1,2-Dimethylhydrazine Aberrant crypt foci Animal tumors. Experimental tumors Animals Biological and medical sciences Colon Colon - drug effects Colon - pathology Colon - ultrastructure Crypt isolation technique Dimethylhydrazines - pharmacology Experimental digestive system and abdominal tumors Fission mechanism Medical sciences Microscopy, Electron, Scanning Mutagens - pharmacology Rats Rats, Inbred F344 Tumors |
| title | Development of Aberrant Crypt Foci Involves a Fission Mechanism as Revealed by Isolation of Aberrant Crypts |
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