Involvement of Vascular Endothelial Growth Factor in Kaposi's Sarcoma Associated with Acquired Immunodeficiency Syndrome
To examine the role of vascular endothelial growth factor (VEGF) in the development of edema associated with Kaposi's sarcoma (KS) in acquired immunodeficiency syndrome (AIDS), we exploited animal model systems to detect the activity that induces vascular hyper‐permeability (VHP) using cultured...
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| Veröffentlicht in: | Cancer science 1996-11, Vol.87 (11), p.1143-1152 |
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| creator | Sakurada, Shinsaku Kato, Tetsuji Mashiba, Kohichi Mori, Shigeo Okamoto, Takashi |
| description | To examine the role of vascular endothelial growth factor (VEGF) in the development of edema associated with Kaposi's sarcoma (KS) in acquired immunodeficiency syndrome (AIDS), we exploited animal model systems to detect the activity that induces vascular hyper‐permeability (VHP) using cultured AIDS‐KS spindle cells. Cultured AIDS‐KS spindle cells and conditioned medium (AIDS‐KS‐CM) that had been semi‐purified through a heparin affinity column were tested for the ability to induce VHP in animals. The AIDS‐KS spindle cells and AIDS‐KS‐CM induced VHP that was histamine‐independent. The VHP‐inducing activity was detected in the 0.5 M NaCl fraction from the heparin affinity column and was blocked by anti‐VEGF neutralizing antibody. In addition, the production of VEGF was demonstrated in fresh AIDS‐KS tissue as well as in cultured AIDS‐KS cells, while control cells were negative for VEGF production. From these observations, we concluded that AIDS‐KS cells produce a factor(s) that promotes VHP, and this factor could be VEGF. |
| doi_str_mv | 10.1111/j.1349-7006.1996.tb03124.x |
| format | Article |
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Cultured AIDS‐KS spindle cells and conditioned medium (AIDS‐KS‐CM) that had been semi‐purified through a heparin affinity column were tested for the ability to induce VHP in animals. The AIDS‐KS spindle cells and AIDS‐KS‐CM induced VHP that was histamine‐independent. The VHP‐inducing activity was detected in the 0.5 M NaCl fraction from the heparin affinity column and was blocked by anti‐VEGF neutralizing antibody. In addition, the production of VEGF was demonstrated in fresh AIDS‐KS tissue as well as in cultured AIDS‐KS cells, while control cells were negative for VEGF production. From these observations, we concluded that AIDS‐KS cells produce a factor(s) that promotes VHP, and this factor could be VEGF.</description><identifier>ISSN: 0910-5050</identifier><identifier>ISSN: 1347-9032</identifier><identifier>EISSN: 1349-7006</identifier><identifier>EISSN: 1876-4673</identifier><identifier>DOI: 10.1111/j.1349-7006.1996.tb03124.x</identifier><identifier>PMID: 9045943</identifier><identifier>CODEN: GANNA2</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Acquired immune deficiency syndrome ; Acquired Immunodeficiency Syndrome - complications ; Acquired Immunodeficiency Syndrome - physiopathology ; Acquired immuno‐deficiency syndrome ; Affinity ; AIDS ; Animal models ; Animals ; Biological and medical sciences ; Capillary Permeability ; Cells, Cultured ; Chromatography, Affinity ; Culture Media ; Cytokines - physiology ; Disease Models, Animal ; Edema ; Edema - etiology ; Edema - physiopathology ; Endothelial Growth Factors - physiology ; Experimental and animal immunopathology. Animal models ; Female ; Guinea Pigs ; Heparin ; Histamine ; Humans ; Immunodeficiency ; Immunopathology ; Kaposi's sarcoma ; Kaposis sarcoma ; Lymphokines - physiology ; Male ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Middle Aged ; Permeability ; Rabbits ; Sarcoma, Kaposi - blood supply ; Sarcoma, Kaposi - chemically induced ; Sarcoma, Kaposi - virology ; Sodium chloride ; Vascular endothelial growth factor ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factors</subject><ispartof>Cancer science, 1996-11, Vol.87 (11), p.1143-1152</ispartof><rights>1997 INIST-CNRS</rights><rights>Copyright John Wiley & Sons, Inc. Nov 1996</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5943-546cbd7b9dd910e5bd7ba0b7d4c90f408d93cd951242326c4d23a3fee6c8dd063</citedby><cites>FETCH-LOGICAL-c5943-546cbd7b9dd910e5bd7ba0b7d4c90f408d93cd951242326c4d23a3fee6c8dd063</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921004/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921004/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,1417,27924,27925,45574,45575,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2580182$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9045943$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sakurada, Shinsaku</creatorcontrib><creatorcontrib>Kato, Tetsuji</creatorcontrib><creatorcontrib>Mashiba, Kohichi</creatorcontrib><creatorcontrib>Mori, Shigeo</creatorcontrib><creatorcontrib>Okamoto, Takashi</creatorcontrib><title>Involvement of Vascular Endothelial Growth Factor in Kaposi's Sarcoma Associated with Acquired Immunodeficiency Syndrome</title><title>Cancer science</title><addtitle>Jpn J Cancer Res</addtitle><description>To examine the role of vascular endothelial growth factor (VEGF) in the development of edema associated with Kaposi's sarcoma (KS) in acquired immunodeficiency syndrome (AIDS), we exploited animal model systems to detect the activity that induces vascular hyper‐permeability (VHP) using cultured AIDS‐KS spindle cells. Cultured AIDS‐KS spindle cells and conditioned medium (AIDS‐KS‐CM) that had been semi‐purified through a heparin affinity column were tested for the ability to induce VHP in animals. The AIDS‐KS spindle cells and AIDS‐KS‐CM induced VHP that was histamine‐independent. The VHP‐inducing activity was detected in the 0.5 M NaCl fraction from the heparin affinity column and was blocked by anti‐VEGF neutralizing antibody. In addition, the production of VEGF was demonstrated in fresh AIDS‐KS tissue as well as in cultured AIDS‐KS cells, while control cells were negative for VEGF production. From these observations, we concluded that AIDS‐KS cells produce a factor(s) that promotes VHP, and this factor could be VEGF.</description><subject>Acquired immune deficiency syndrome</subject><subject>Acquired Immunodeficiency Syndrome - complications</subject><subject>Acquired Immunodeficiency Syndrome - physiopathology</subject><subject>Acquired immuno‐deficiency syndrome</subject><subject>Affinity</subject><subject>AIDS</subject><subject>Animal models</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Capillary Permeability</subject><subject>Cells, Cultured</subject><subject>Chromatography, Affinity</subject><subject>Culture Media</subject><subject>Cytokines - physiology</subject><subject>Disease Models, Animal</subject><subject>Edema</subject><subject>Edema - etiology</subject><subject>Edema - physiopathology</subject><subject>Endothelial Growth Factors - physiology</subject><subject>Experimental and animal immunopathology. Animal models</subject><subject>Female</subject><subject>Guinea Pigs</subject><subject>Heparin</subject><subject>Histamine</subject><subject>Humans</subject><subject>Immunodeficiency</subject><subject>Immunopathology</subject><subject>Kaposi's sarcoma</subject><subject>Kaposis sarcoma</subject><subject>Lymphokines - physiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Nude</subject><subject>Middle Aged</subject><subject>Permeability</subject><subject>Rabbits</subject><subject>Sarcoma, Kaposi - blood supply</subject><subject>Sarcoma, Kaposi - chemically induced</subject><subject>Sarcoma, Kaposi - virology</subject><subject>Sodium chloride</subject><subject>Vascular endothelial growth factor</subject><subject>Vascular Endothelial Growth Factor A</subject><subject>Vascular Endothelial Growth Factors</subject><issn>0910-5050</issn><issn>1347-9032</issn><issn>1349-7006</issn><issn>1876-4673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqVUc2O0zAYjBBoKQuPgGQBglPC58ROYw6gquouFStxWOBqObZDXSV210768_Y4NKqAG77Y1sw3nvEkySsMGY7r_TbDBWHpHKDMMGNl1tdQ4Jxkx0fJ7AI9TmbAMKQUKDxNnoWwBcBzKPOr5IoBoYwUs-S4tnvX7nWnbY9cg36IIIdWeLSyyvUb3RrRolvvDv0G3QjZO4-MRV_EzgXzLqB74aXrBFqE4KQRvVboYCJ1IR8G4-Nt3XWDdUo3Rhpt5Qndn6zyrtPPkyeNaIN-Me3Xyfeb1bfl5_Tu6-16ubhL5WgwpaSUtZrXTKmYRdPxLKCeKyIZNAQqxQqpGI3p8yIvJVF5IYpG61JWSkFZXCcfz7q7oe60kjGnFy3fedMJf-JOGP43Ys2G_3R7TlmOAUgUeDsJePcw6NDzzgSp21ZY7YbAMWUVphQi8fU_xK0bvI3heE7i15Mcfvv5cGZJ70LwurlYwcDHdvmWjxXysUI-tsundvkxDr_8M8xldKoz4m8mPNYo2sYLK0240HJaAa7ySPt0ph1Mq0__YYAvFyuM40O_AP23xFc</recordid><startdate>199611</startdate><enddate>199611</enddate><creator>Sakurada, Shinsaku</creator><creator>Kato, Tetsuji</creator><creator>Mashiba, Kohichi</creator><creator>Mori, Shigeo</creator><creator>Okamoto, Takashi</creator><general>Blackwell Publishing Ltd</general><general>Japanese Cancer Association</general><general>John Wiley & Sons, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7TO</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>199611</creationdate><title>Involvement of Vascular Endothelial Growth Factor in Kaposi's Sarcoma Associated with Acquired Immunodeficiency Syndrome</title><author>Sakurada, Shinsaku ; Kato, Tetsuji ; Mashiba, Kohichi ; Mori, Shigeo ; Okamoto, Takashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5943-546cbd7b9dd910e5bd7ba0b7d4c90f408d93cd951242326c4d23a3fee6c8dd063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>Acquired Immunodeficiency Syndrome - complications</topic><topic>Acquired Immunodeficiency Syndrome - physiopathology</topic><topic>Acquired immuno‐deficiency syndrome</topic><topic>Affinity</topic><topic>AIDS</topic><topic>Animal models</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Capillary Permeability</topic><topic>Cells, Cultured</topic><topic>Chromatography, Affinity</topic><topic>Culture Media</topic><topic>Cytokines - physiology</topic><topic>Disease Models, Animal</topic><topic>Edema</topic><topic>Edema - etiology</topic><topic>Edema - physiopathology</topic><topic>Endothelial Growth Factors - physiology</topic><topic>Experimental and animal immunopathology. Animal models</topic><topic>Female</topic><topic>Guinea Pigs</topic><topic>Heparin</topic><topic>Histamine</topic><topic>Humans</topic><topic>Immunodeficiency</topic><topic>Immunopathology</topic><topic>Kaposi's sarcoma</topic><topic>Kaposis sarcoma</topic><topic>Lymphokines - physiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Nude</topic><topic>Middle Aged</topic><topic>Permeability</topic><topic>Rabbits</topic><topic>Sarcoma, Kaposi - blood supply</topic><topic>Sarcoma, Kaposi - chemically induced</topic><topic>Sarcoma, Kaposi - virology</topic><topic>Sodium chloride</topic><topic>Vascular endothelial growth factor</topic><topic>Vascular Endothelial Growth Factor A</topic><topic>Vascular Endothelial Growth Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sakurada, Shinsaku</creatorcontrib><creatorcontrib>Kato, Tetsuji</creatorcontrib><creatorcontrib>Mashiba, Kohichi</creatorcontrib><creatorcontrib>Mori, Shigeo</creatorcontrib><creatorcontrib>Okamoto, Takashi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sakurada, Shinsaku</au><au>Kato, Tetsuji</au><au>Mashiba, Kohichi</au><au>Mori, Shigeo</au><au>Okamoto, Takashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Involvement of Vascular Endothelial Growth Factor in Kaposi's Sarcoma Associated with Acquired Immunodeficiency Syndrome</atitle><jtitle>Cancer science</jtitle><addtitle>Jpn J Cancer Res</addtitle><date>1996-11</date><risdate>1996</risdate><volume>87</volume><issue>11</issue><spage>1143</spage><epage>1152</epage><pages>1143-1152</pages><issn>0910-5050</issn><issn>1347-9032</issn><eissn>1349-7006</eissn><eissn>1876-4673</eissn><coden>GANNA2</coden><abstract>To examine the role of vascular endothelial growth factor (VEGF) in the development of edema associated with Kaposi's sarcoma (KS) in acquired immunodeficiency syndrome (AIDS), we exploited animal model systems to detect the activity that induces vascular hyper‐permeability (VHP) using cultured AIDS‐KS spindle cells. Cultured AIDS‐KS spindle cells and conditioned medium (AIDS‐KS‐CM) that had been semi‐purified through a heparin affinity column were tested for the ability to induce VHP in animals. The AIDS‐KS spindle cells and AIDS‐KS‐CM induced VHP that was histamine‐independent. The VHP‐inducing activity was detected in the 0.5 M NaCl fraction from the heparin affinity column and was blocked by anti‐VEGF neutralizing antibody. In addition, the production of VEGF was demonstrated in fresh AIDS‐KS tissue as well as in cultured AIDS‐KS cells, while control cells were negative for VEGF production. From these observations, we concluded that AIDS‐KS cells produce a factor(s) that promotes VHP, and this factor could be VEGF.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>9045943</pmid><doi>10.1111/j.1349-7006.1996.tb03124.x</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cancer science, 1996-11, Vol.87 (11), p.1143-1152 |
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| source | MEDLINE; Wiley Journals; IngentaConnect Free/Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Acquired immune deficiency syndrome Acquired Immunodeficiency Syndrome - complications Acquired Immunodeficiency Syndrome - physiopathology Acquired immuno‐deficiency syndrome Affinity AIDS Animal models Animals Biological and medical sciences Capillary Permeability Cells, Cultured Chromatography, Affinity Culture Media Cytokines - physiology Disease Models, Animal Edema Edema - etiology Edema - physiopathology Endothelial Growth Factors - physiology Experimental and animal immunopathology. Animal models Female Guinea Pigs Heparin Histamine Humans Immunodeficiency Immunopathology Kaposi's sarcoma Kaposis sarcoma Lymphokines - physiology Male Medical sciences Mice Mice, Inbred BALB C Mice, Nude Middle Aged Permeability Rabbits Sarcoma, Kaposi - blood supply Sarcoma, Kaposi - chemically induced Sarcoma, Kaposi - virology Sodium chloride Vascular endothelial growth factor Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors |
| title | Involvement of Vascular Endothelial Growth Factor in Kaposi's Sarcoma Associated with Acquired Immunodeficiency Syndrome |
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