Maternal IL-6 during pregnancy can be estimated from newborn brain connectivity and predicts future working memory in offspring
Several lines of evidence support the link between maternal inflammation during pregnancy and increased likelihood of neurodevelopmental and psychiatric disorders in offspring. This longitudinal study seeks to advance understanding regarding implications of systemic maternal inflammation during preg...
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| Veröffentlicht in: | Nature neuroscience 2018-05, Vol.21 (5), p.765-772 |
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| creator | Rudolph, Marc D. Graham, Alice M. Feczko, Eric Miranda-Dominguez, Oscar Rasmussen, Jerod M. Nardos, Rahel Entringer, Sonja Wadhwa, Pathik D. Buss, Claudia Fair, Damien A. |
| description | Several lines of evidence support the link between maternal inflammation during pregnancy and increased likelihood of neurodevelopmental and psychiatric disorders in offspring. This longitudinal study seeks to advance understanding regarding implications of systemic maternal inflammation during pregnancy, indexed by plasma interleukin-6 (IL-6) concentrations, for large-scale brain system development and emerging executive function skills in offspring. We assessed maternal IL-6 during pregnancy, functional magnetic resonance imaging acquired in neonates, and working memory (an important component of executive function) at 2 years of age. Functional connectivity within and between multiple neonatal brain networks can be modeled to estimate maternal IL-6 concentrations during pregnancy. Brain regions heavily weighted in these models overlap substantially with those supporting working memory in a large meta-analysis. Maternal IL-6 also directly accounts for a portion of the variance of working memory at 2 years of age. Findings highlight the association of maternal inflammation during pregnancy with the developing functional architecture of the brain and emerging executive function.
The authors show that maternal inflammation during pregnancy, indexed by IL-6, can be estimated from the newborn brain connectome and predicts future working memory performance in offspring at two years of age. |
| doi_str_mv | 10.1038/s41593-018-0128-y |
| format | Article |
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The authors show that maternal inflammation during pregnancy, indexed by IL-6, can be estimated from the newborn brain connectome and predicts future working memory performance in offspring at two years of age.</description><identifier>ISSN: 1097-6256</identifier><identifier>EISSN: 1546-1726</identifier><identifier>DOI: 10.1038/s41593-018-0128-y</identifier><identifier>PMID: 29632361</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>631/378 ; 631/378/371 ; 631/477 ; Adult ; Analysis ; Animal Genetics and Genomics ; Animals ; Behavioral Sciences ; Biological Techniques ; Biomedical and Life Sciences ; Biomedicine ; Brain ; Brain - physiology ; Brain architecture ; Brain mapping ; Child Development - physiology ; Child, Preschool ; Complications and side effects ; Correlation analysis ; Emotions ; Executive function ; Executive Function - physiology ; Female ; Functional magnetic resonance imaging ; Health aspects ; Humans ; Image acquisition ; Image Processing, Computer-Assisted ; Infant ; Infant, Newborn ; Inflammation ; Interleukin 6 ; Interleukin-6 - analysis ; Interleukin-6 - metabolism ; Interleukins ; Longitudinal Studies ; Magnetic Resonance Imaging ; Male ; Medical research ; Memory ; Memory, Short-Term - physiology ; Mental disorders ; Neonates ; Neural networks ; Neural Pathways - physiology ; Neurobiology ; Neurodevelopmental disorders ; Neuroimaging ; Neurosciences ; Newborn infants ; Offspring ; Predictive Value of Tests ; Pregnancy ; Pregnant women ; Psychological aspects ; Psychomotor Performance - physiology ; Risk factors ; Short term memory ; Systematic review</subject><ispartof>Nature neuroscience, 2018-05, Vol.21 (5), p.765-772</ispartof><rights>The Author(s) 2018</rights><rights>COPYRIGHT 2018 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group May 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c571t-88889c4691fd7346d0b0ce13bab4dfebe5fe2346d65e58a5da01aecb0e2ce9e13</citedby><cites>FETCH-LOGICAL-c571t-88889c4691fd7346d0b0ce13bab4dfebe5fe2346d65e58a5da01aecb0e2ce9e13</cites><orcidid>0000-0002-8738-3133 ; 0000-0001-8602-393X ; 0000-0002-3622-0166</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41593-018-0128-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41593-018-0128-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29632361$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rudolph, Marc D.</creatorcontrib><creatorcontrib>Graham, Alice M.</creatorcontrib><creatorcontrib>Feczko, Eric</creatorcontrib><creatorcontrib>Miranda-Dominguez, Oscar</creatorcontrib><creatorcontrib>Rasmussen, Jerod M.</creatorcontrib><creatorcontrib>Nardos, Rahel</creatorcontrib><creatorcontrib>Entringer, Sonja</creatorcontrib><creatorcontrib>Wadhwa, Pathik D.</creatorcontrib><creatorcontrib>Buss, Claudia</creatorcontrib><creatorcontrib>Fair, Damien A.</creatorcontrib><title>Maternal IL-6 during pregnancy can be estimated from newborn brain connectivity and predicts future working memory in offspring</title><title>Nature neuroscience</title><addtitle>Nat Neurosci</addtitle><addtitle>Nat Neurosci</addtitle><description>Several lines of evidence support the link between maternal inflammation during pregnancy and increased likelihood of neurodevelopmental and psychiatric disorders in offspring. This longitudinal study seeks to advance understanding regarding implications of systemic maternal inflammation during pregnancy, indexed by plasma interleukin-6 (IL-6) concentrations, for large-scale brain system development and emerging executive function skills in offspring. We assessed maternal IL-6 during pregnancy, functional magnetic resonance imaging acquired in neonates, and working memory (an important component of executive function) at 2 years of age. Functional connectivity within and between multiple neonatal brain networks can be modeled to estimate maternal IL-6 concentrations during pregnancy. Brain regions heavily weighted in these models overlap substantially with those supporting working memory in a large meta-analysis. Maternal IL-6 also directly accounts for a portion of the variance of working memory at 2 years of age. Findings highlight the association of maternal inflammation during pregnancy with the developing functional architecture of the brain and emerging executive function.
The authors show that maternal inflammation during pregnancy, indexed by IL-6, can be estimated from the newborn brain connectome and predicts future working memory performance in offspring at two years of age.</description><subject>631/378</subject><subject>631/378/371</subject><subject>631/477</subject><subject>Adult</subject><subject>Analysis</subject><subject>Animal Genetics and Genomics</subject><subject>Animals</subject><subject>Behavioral Sciences</subject><subject>Biological Techniques</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain</subject><subject>Brain - physiology</subject><subject>Brain architecture</subject><subject>Brain mapping</subject><subject>Child Development - physiology</subject><subject>Child, Preschool</subject><subject>Complications and side effects</subject><subject>Correlation analysis</subject><subject>Emotions</subject><subject>Executive function</subject><subject>Executive Function - physiology</subject><subject>Female</subject><subject>Functional magnetic resonance imaging</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Image acquisition</subject><subject>Image Processing, Computer-Assisted</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Inflammation</subject><subject>Interleukin 6</subject><subject>Interleukin-6 - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nature neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rudolph, Marc D.</au><au>Graham, Alice M.</au><au>Feczko, Eric</au><au>Miranda-Dominguez, Oscar</au><au>Rasmussen, Jerod M.</au><au>Nardos, Rahel</au><au>Entringer, Sonja</au><au>Wadhwa, Pathik D.</au><au>Buss, Claudia</au><au>Fair, Damien A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal IL-6 during pregnancy can be estimated from newborn brain connectivity and predicts future working memory in offspring</atitle><jtitle>Nature neuroscience</jtitle><stitle>Nat Neurosci</stitle><addtitle>Nat Neurosci</addtitle><date>2018-05-01</date><risdate>2018</risdate><volume>21</volume><issue>5</issue><spage>765</spage><epage>772</epage><pages>765-772</pages><issn>1097-6256</issn><eissn>1546-1726</eissn><abstract>Several lines of evidence support the link between maternal inflammation during pregnancy and increased likelihood of neurodevelopmental and psychiatric disorders in offspring. This longitudinal study seeks to advance understanding regarding implications of systemic maternal inflammation during pregnancy, indexed by plasma interleukin-6 (IL-6) concentrations, for large-scale brain system development and emerging executive function skills in offspring. We assessed maternal IL-6 during pregnancy, functional magnetic resonance imaging acquired in neonates, and working memory (an important component of executive function) at 2 years of age. Functional connectivity within and between multiple neonatal brain networks can be modeled to estimate maternal IL-6 concentrations during pregnancy. Brain regions heavily weighted in these models overlap substantially with those supporting working memory in a large meta-analysis. Maternal IL-6 also directly accounts for a portion of the variance of working memory at 2 years of age. Findings highlight the association of maternal inflammation during pregnancy with the developing functional architecture of the brain and emerging executive function.
The authors show that maternal inflammation during pregnancy, indexed by IL-6, can be estimated from the newborn brain connectome and predicts future working memory performance in offspring at two years of age.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>29632361</pmid><doi>10.1038/s41593-018-0128-y</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-8738-3133</orcidid><orcidid>https://orcid.org/0000-0001-8602-393X</orcidid><orcidid>https://orcid.org/0000-0002-3622-0166</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 631/378 631/378/371 631/477 Adult Analysis Animal Genetics and Genomics Animals Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Brain Brain - physiology Brain architecture Brain mapping Child Development - physiology Child, Preschool Complications and side effects Correlation analysis Emotions Executive function Executive Function - physiology Female Functional magnetic resonance imaging Health aspects Humans Image acquisition Image Processing, Computer-Assisted Infant Infant, Newborn Inflammation Interleukin 6 Interleukin-6 - analysis Interleukin-6 - metabolism Interleukins Longitudinal Studies Magnetic Resonance Imaging Male Medical research Memory Memory, Short-Term - physiology Mental disorders Neonates Neural networks Neural Pathways - physiology Neurobiology Neurodevelopmental disorders Neuroimaging Neurosciences Newborn infants Offspring Predictive Value of Tests Pregnancy Pregnant women Psychological aspects Psychomotor Performance - physiology Risk factors Short term memory Systematic review |
| title | Maternal IL-6 during pregnancy can be estimated from newborn brain connectivity and predicts future working memory in offspring |
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