N‐Acetyltransferase Activity in the Urine in Japanese Subjects: Comparison in Healthy Persons and Bladder Cancer Patients
The activity of urinary N‐acetylamino‐transferase was determined by high‐performance liquid chro‐matographic assay of acetylisoniazid and isoniazid after administration of isoniazid to healthy Japanese male and bladder cancer patients in Japan. The healthy subjects were 47 college students and 44 co...
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| Veröffentlicht in: | Cancer science 1995-12, Vol.86 (12), p.1179-1181 |
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| creator | Ishizu, Sumiko Hashida, Chise Hanaoka, Tomoyuki Maeda, Keiko Ohishi, Yukihiko |
| description | The activity of urinary N‐acetylamino‐transferase was determined by high‐performance liquid chro‐matographic assay of acetylisoniazid and isoniazid after administration of isoniazid to healthy Japanese male and bladder cancer patients in Japan. The healthy subjects were 47 college students and 44 company employees ranging from 18 to 64 years old (mean±SD=34.5±13.7). The bladder cancer group consisted of 58 male and 13 female patients, ranging from 28 to 82 years old (mean±SD =60.8 ±11.6), who were being treated at several hospitals. The slow phenotype, defined as an acetylation ratio (acetylisoniazid/isoniazid) of less than 2.0, was observed in 13 (14.3%) of the 91 healthy subjects, and in 20 (28.2%) of the 71 bladder cancer patients; the difference between the two groups is significant (P < 0.05). A histogram of the acetylation ratio values showed an overall leftward shift of the patient group, indicating low values of acetylation ratio in this group as a whole (P < 0.01). |
| doi_str_mv | 10.1111/j.1349-7006.1995.tb03312.x |
| format | Article |
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The healthy subjects were 47 college students and 44 company employees ranging from 18 to 64 years old (mean±SD=34.5±13.7). The bladder cancer group consisted of 58 male and 13 female patients, ranging from 28 to 82 years old (mean±SD =60.8 ±11.6), who were being treated at several hospitals. The slow phenotype, defined as an acetylation ratio (acetylisoniazid/isoniazid) of less than 2.0, was observed in 13 (14.3%) of the 91 healthy subjects, and in 20 (28.2%) of the 71 bladder cancer patients; the difference between the two groups is significant (P < 0.05). A histogram of the acetylation ratio values showed an overall leftward shift of the patient group, indicating low values of acetylation ratio in this group as a whole (P < 0.01).</description><identifier>ISSN: 0910-5050</identifier><identifier>ISSN: 1347-9032</identifier><identifier>EISSN: 1349-7006</identifier><identifier>EISSN: 1876-4673</identifier><identifier>DOI: 10.1111/j.1349-7006.1995.tb03312.x</identifier><identifier>PMID: 8636007</identifier><identifier>CODEN: GANNA2</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Acetylation ; Acetyltransferase ; AcINH/INH ratio ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Arylamine N-Acetyltransferase - genetics ; Arylamine N-Acetyltransferase - urine ; Asian Continental Ancestry Group - genetics ; Biological and medical sciences ; Bladder cancer ; Cancer ; Disease Susceptibility - ethnology ; Female ; Genetic Predisposition to Disease ; Humans ; Isoniazid ; Isoniazid - analogs & derivatives ; Isoniazid - pharmacokinetics ; Isoniazid - urine ; Japan ; Japanese healthy men ; Male ; Medical sciences ; Middle Aged ; Neoplasm Proteins - urine ; Nephrology. Urinary tract diseases ; N‐Acetyltransferase phenotype ; Occupational Diseases - chemically induced ; Occupational Exposure ; Phenotype ; Phenotypes ; Smoking ; Tumors of the urinary system ; Urinary Bladder Neoplasms - chemically induced ; Urinary Bladder Neoplasms - enzymology ; Urinary tract. Prostate gland</subject><ispartof>Cancer science, 1995-12, Vol.86 (12), p.1179-1181</ispartof><rights>1996 INIST-CNRS</rights><rights>Copyright John Wiley & Sons, Inc. Dec 1995</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6339-3709f93ed4c0bf71afd62b8006b3abad5e6718b3979c15a5d1ee5598088711b03</citedby><cites>FETCH-LOGICAL-c6339-3709f93ed4c0bf71afd62b8006b3abad5e6718b3979c15a5d1ee5598088711b03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920664/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920664/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,1417,27924,27925,45574,45575,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2955029$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8636007$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ishizu, Sumiko</creatorcontrib><creatorcontrib>Hashida, Chise</creatorcontrib><creatorcontrib>Hanaoka, Tomoyuki</creatorcontrib><creatorcontrib>Maeda, Keiko</creatorcontrib><creatorcontrib>Ohishi, Yukihiko</creatorcontrib><title>N‐Acetyltransferase Activity in the Urine in Japanese Subjects: Comparison in Healthy Persons and Bladder Cancer Patients</title><title>Cancer science</title><addtitle>Jpn J Cancer Res</addtitle><description>The activity of urinary N‐acetylamino‐transferase was determined by high‐performance liquid chro‐matographic assay of acetylisoniazid and isoniazid after administration of isoniazid to healthy Japanese male and bladder cancer patients in Japan. The healthy subjects were 47 college students and 44 company employees ranging from 18 to 64 years old (mean±SD=34.5±13.7). The bladder cancer group consisted of 58 male and 13 female patients, ranging from 28 to 82 years old (mean±SD =60.8 ±11.6), who were being treated at several hospitals. The slow phenotype, defined as an acetylation ratio (acetylisoniazid/isoniazid) of less than 2.0, was observed in 13 (14.3%) of the 91 healthy subjects, and in 20 (28.2%) of the 71 bladder cancer patients; the difference between the two groups is significant (P < 0.05). A histogram of the acetylation ratio values showed an overall leftward shift of the patient group, indicating low values of acetylation ratio in this group as a whole (P < 0.01).</description><subject>Acetylation</subject><subject>Acetyltransferase</subject><subject>AcINH/INH ratio</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Arylamine N-Acetyltransferase - genetics</subject><subject>Arylamine N-Acetyltransferase - urine</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Biological and medical sciences</subject><subject>Bladder cancer</subject><subject>Cancer</subject><subject>Disease Susceptibility - ethnology</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Isoniazid</subject><subject>Isoniazid - analogs & derivatives</subject><subject>Isoniazid - pharmacokinetics</subject><subject>Isoniazid - urine</subject><subject>Japan</subject><subject>Japanese healthy men</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Proteins - urine</subject><subject>Nephrology. Urinary tract diseases</subject><subject>N‐Acetyltransferase phenotype</subject><subject>Occupational Diseases - chemically induced</subject><subject>Occupational Exposure</subject><subject>Phenotype</subject><subject>Phenotypes</subject><subject>Smoking</subject><subject>Tumors of the urinary system</subject><subject>Urinary Bladder Neoplasms - chemically induced</subject><subject>Urinary Bladder Neoplasms - enzymology</subject><subject>Urinary tract. Prostate gland</subject><issn>0910-5050</issn><issn>1347-9032</issn><issn>1349-7006</issn><issn>1876-4673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqVkcFu1DAQhi0EKkvhEZAi4Jpgx-sk7gG0RKUFVVAJerYmzoT1Kusstrc04sIj8Ix9EhxttIIjvozs__PMb_-EvGA0Y3G93mSML2VaUlpkTEqRhYZyzvLs7gFZHKWHZEElo6mggj4mT7zfUMpKWuQn5KQqeEFpuSA_P93_-r3SGMY-OLC-Qwcek5UO5taEMTE2CWtMbpyxOG0-wg4sRuLLvtmgDv4sqYftDpzxg52AS4Q-rMfkGl088QnYNnnXQ9uiS2qwOpZrCAZt8E_Jow56j8_mekpu3p9_rS_Tq88XH-rVVaoLzmXKSyo7ybFdatp0JYOuLfKmii9sODTQCixKVjVcllIzAaJliELIilZVyVj8mVPy5tB3t2-22Oo420Gvds5swY1qAKP-VaxZq2_DrRIyp0WxjA1ezg3c8H2PPqjNsHc2elY5lzJOjh4jdXagtBu8d9gdJzCqptzURk3hqCkcNeWm5tzUXbz8_G-Px6tzUFF_NevgNfRdzEobf8RyKQTNZcTeHrAfpsfxPwyoenXOWCn5H8vft60</recordid><startdate>199512</startdate><enddate>199512</enddate><creator>Ishizu, Sumiko</creator><creator>Hashida, Chise</creator><creator>Hanaoka, Tomoyuki</creator><creator>Maeda, Keiko</creator><creator>Ohishi, Yukihiko</creator><general>Blackwell Publishing Ltd</general><general>Japanese Cancer Association</general><general>John Wiley & Sons, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>199512</creationdate><title>N‐Acetyltransferase Activity in the Urine in Japanese Subjects: Comparison in Healthy Persons and Bladder Cancer Patients</title><author>Ishizu, Sumiko ; Hashida, Chise ; Hanaoka, Tomoyuki ; Maeda, Keiko ; Ohishi, Yukihiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6339-3709f93ed4c0bf71afd62b8006b3abad5e6718b3979c15a5d1ee5598088711b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Acetylation</topic><topic>Acetyltransferase</topic><topic>AcINH/INH ratio</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Arylamine N-Acetyltransferase - genetics</topic><topic>Arylamine N-Acetyltransferase - urine</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Biological and medical sciences</topic><topic>Bladder cancer</topic><topic>Cancer</topic><topic>Disease Susceptibility - ethnology</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Isoniazid</topic><topic>Isoniazid - analogs & derivatives</topic><topic>Isoniazid - pharmacokinetics</topic><topic>Isoniazid - urine</topic><topic>Japan</topic><topic>Japanese healthy men</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Proteins - urine</topic><topic>Nephrology. Urinary tract diseases</topic><topic>N‐Acetyltransferase phenotype</topic><topic>Occupational Diseases - chemically induced</topic><topic>Occupational Exposure</topic><topic>Phenotype</topic><topic>Phenotypes</topic><topic>Smoking</topic><topic>Tumors of the urinary system</topic><topic>Urinary Bladder Neoplasms - chemically induced</topic><topic>Urinary Bladder Neoplasms - enzymology</topic><topic>Urinary tract. Prostate gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ishizu, Sumiko</creatorcontrib><creatorcontrib>Hashida, Chise</creatorcontrib><creatorcontrib>Hanaoka, Tomoyuki</creatorcontrib><creatorcontrib>Maeda, Keiko</creatorcontrib><creatorcontrib>Ohishi, Yukihiko</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Biological Science Collection</collection><collection>ProQuest Biological Science Journals</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ishizu, Sumiko</au><au>Hashida, Chise</au><au>Hanaoka, Tomoyuki</au><au>Maeda, Keiko</au><au>Ohishi, Yukihiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>N‐Acetyltransferase Activity in the Urine in Japanese Subjects: Comparison in Healthy Persons and Bladder Cancer Patients</atitle><jtitle>Cancer science</jtitle><addtitle>Jpn J Cancer Res</addtitle><date>1995-12</date><risdate>1995</risdate><volume>86</volume><issue>12</issue><spage>1179</spage><epage>1181</epage><pages>1179-1181</pages><issn>0910-5050</issn><issn>1347-9032</issn><eissn>1349-7006</eissn><eissn>1876-4673</eissn><coden>GANNA2</coden><abstract>The activity of urinary N‐acetylamino‐transferase was determined by high‐performance liquid chro‐matographic assay of acetylisoniazid and isoniazid after administration of isoniazid to healthy Japanese male and bladder cancer patients in Japan. The healthy subjects were 47 college students and 44 company employees ranging from 18 to 64 years old (mean±SD=34.5±13.7). The bladder cancer group consisted of 58 male and 13 female patients, ranging from 28 to 82 years old (mean±SD =60.8 ±11.6), who were being treated at several hospitals. The slow phenotype, defined as an acetylation ratio (acetylisoniazid/isoniazid) of less than 2.0, was observed in 13 (14.3%) of the 91 healthy subjects, and in 20 (28.2%) of the 71 bladder cancer patients; the difference between the two groups is significant (P < 0.05). A histogram of the acetylation ratio values showed an overall leftward shift of the patient group, indicating low values of acetylation ratio in this group as a whole (P < 0.01).</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>8636007</pmid><doi>10.1111/j.1349-7006.1995.tb03312.x</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0910-5050 |
| ispartof | Cancer science, 1995-12, Vol.86 (12), p.1179-1181 |
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| language | eng |
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| source | Wiley-Blackwell Journals; IngentaConnect Backfiles; MEDLINE; PubMed Central; EZB Electronic Journals Library |
| subjects | Acetylation Acetyltransferase AcINH/INH ratio Adolescent Adult Aged Aged, 80 and over Arylamine N-Acetyltransferase - genetics Arylamine N-Acetyltransferase - urine Asian Continental Ancestry Group - genetics Biological and medical sciences Bladder cancer Cancer Disease Susceptibility - ethnology Female Genetic Predisposition to Disease Humans Isoniazid Isoniazid - analogs & derivatives Isoniazid - pharmacokinetics Isoniazid - urine Japan Japanese healthy men Male Medical sciences Middle Aged Neoplasm Proteins - urine Nephrology. Urinary tract diseases N‐Acetyltransferase phenotype Occupational Diseases - chemically induced Occupational Exposure Phenotype Phenotypes Smoking Tumors of the urinary system Urinary Bladder Neoplasms - chemically induced Urinary Bladder Neoplasms - enzymology Urinary tract. Prostate gland |
| title | N‐Acetyltransferase Activity in the Urine in Japanese Subjects: Comparison in Healthy Persons and Bladder Cancer Patients |
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