Inhibition of Tumor Cell Haptotaxis by Sodium D‐Glucaro‐δ‐lactam (ND2001)

We used the Boyden chamber system to investigate the mechanism by which the antimetastatic agent sodium D-glucaro-delta-lactam (ND2001) inhibits tumor cell invasion, and by establishing what ND2001 did not achieve, we were able to pinpoint the areas in which it was successful as an inhibitor. ND2001...

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Veröffentlicht in:	Cancer science 1995-11, Vol.86 (11), p.1080-1085
Hauptverfasser:	Tsuruoka, Tsutomu, Azetaka, Masayuki, Lizuka, Yuraiko, Saito, Koichi, Inouye, Shigeharu, Hosokawa, Masuo, Kobayashi, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - pathology Animals Antineoplastic agents Antineoplastic Agents - pharmacology Biological and medical sciences Carcinoma, Large Cell - pathology Cell Adhesion - drug effects Cell Movement - drug effects Cell Movement - physiology Collagen Collagenases - analysis Depression, Chemical Drug Combinations Female General aspects Glucaric Acid - analogs & derivatives Glucaric Acid - pharmacology Humans Laminin Lung Neoplasms - pathology Medical sciences Melanoma, Experimental - pathology Mice Neoplasm Proteins - analysis Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - physiology Ovarian Neoplasms - pathology Pharmacology. Drug treatments Proteoglycans Tumor Cells, Cultured - drug effects Urinary Bladder Neoplasms - pathology
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