Mismatch repair-deficient status associates with favorable prognosis of Eastern Chinese population with sporadic colorectal cancer
The present study aimed to investigate the expression level of DNA mismatch repair gene (MMR) in in sporadic colorectal cancer (SCRC) in eastern China, and to investigate the association between MMR status and prognosis of patients with SCRC. Patient archives from the Department of Gastrointestinal...
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| Veröffentlicht in: | Oncology letters 2018-05, Vol.15 (5), p.7007-7013 |
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| creator | Gong, Qing Zhang, Huan-Hu Sun, Sheng-Bo Ge, Wen-Min Li, Yue Zhu, Yong-Cun Li, Le-Ping |
| description | The present study aimed to investigate the expression level of DNA mismatch repair gene (MMR) in in sporadic colorectal cancer (SCRC) in eastern China, and to investigate the association between MMR status and prognosis of patients with SCRC. Patient archives from the Department of Gastrointestinal Surgery of Weihai Municipal Hospital (Weihai, China) were retrospectively collected between January 2011 and January 2012. Of the 221 consecutive patients identified, 192 patients who met the criterion were deemed eligible for inclusion. Immunohistochemistry (IHC) was conducted to detect the expression of MMR proteins MutL homolog 1 (MLH1), MutS homolog 2 (MSH2), MSH6 and PMS1 homolog 2, mismatch repair system component (PMS2) expression and mutation in sporadic colorectal cancer (SCRC). Kaplan-Meier plots and log-rank tests were performed to conduct survival analysis and Cox proportional hazard regression models were conducted to determine independent prognostic factors. The total rate of deficient MMR (dMMR) was 14.58% (28/192): MSH6, 0.52% (1/192); PMS2, 4.17% (8/192); MSH2/MSH6, 3.65% (7/192); and MLH1/PMS2, 6.25% (12/192). The dMMR group had a significantly longer overall survival time compared with proficient MMR (pMMR) group (P=0.017). Disease-free survival time of dMMR group was also longer than pMMR group (P=0.027). Multivariate analysis using the Cox regression model confirmed that MMR status was an independent prognostic factor for SCRC. Loss of MMR expression was indicative of a favorable outcome for patients with SCRC, and MMR status could be viewed as an independent prognostic factor. |
| doi_str_mv | 10.3892/ol.2018.8192 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5920361</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A542803878</galeid><sourcerecordid>A542803878</sourcerecordid><originalsourceid>FETCH-LOGICAL-c510t-bf8ac8b16fa2c3f8813ebaa85a5e2b7deef53d81e1c907d41a6917387712bc973</originalsourceid><addsrcrecordid>eNptkk1v1DAQhiMEolXpjTOyhIQ4kCV2vpwLUrUqH1IRFzhbE2eyceW1g8cp4sovx9GWpYuwD7Y8zzu2Z94se86LTSk78dbbjSi43EjeiUfZOW87kfNCisfHfVudZZdEt0UadcOlbJ5mZ6JrRV2J9jz79dnQHqKeWMAZTMgHHI026CKjCHEhBkReG4hI7IeJExvhzgfoLbI5-J3zZIj5kV0DRQyObSfjkFLQz4uFaLw7yGhOqsFopr31AXUEyzQ4jeFZ9mQES3h5v15k395ff91-zG--fPi0vbrJdc2LmPejBC173owgdDlKyUvsAWQNNYq-HRDHuhwkR667oh0qDk3H21K2LRe97tryInt3yDsv_R4Hnf4YwKo5mD2En8qDUacRZya183eq7kRRNjwleH2fIPjvC1JUe0MarQWHfiGVqFpUQtYioS__QW_9Elz6XqIqwevUh-4vtQOLyrjRp3v1mlRdpfbIIr1eJmrzHyrNAfdGe5cals5PBK8eCCYEGyfydlmbQafgmwOogycKOB6LwQu1-kt5q1Z_qdVfCX_xsIBH-I-byt8TGMzh</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2042158869</pqid></control><display><type>article</type><title>Mismatch repair-deficient status associates with favorable prognosis of Eastern Chinese population with sporadic colorectal cancer</title><source>Spandidos Publications Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Gong, Qing ; Zhang, Huan-Hu ; Sun, Sheng-Bo ; Ge, Wen-Min ; Li, Yue ; Zhu, Yong-Cun ; Li, Le-Ping</creator><creatorcontrib>Gong, Qing ; Zhang, Huan-Hu ; Sun, Sheng-Bo ; Ge, Wen-Min ; Li, Yue ; Zhu, Yong-Cun ; Li, Le-Ping</creatorcontrib><description>The present study aimed to investigate the expression level of DNA mismatch repair gene (MMR) in in sporadic colorectal cancer (SCRC) in eastern China, and to investigate the association between MMR status and prognosis of patients with SCRC. Patient archives from the Department of Gastrointestinal Surgery of Weihai Municipal Hospital (Weihai, China) were retrospectively collected between January 2011 and January 2012. Of the 221 consecutive patients identified, 192 patients who met the criterion were deemed eligible for inclusion. Immunohistochemistry (IHC) was conducted to detect the expression of MMR proteins MutL homolog 1 (MLH1), MutS homolog 2 (MSH2), MSH6 and PMS1 homolog 2, mismatch repair system component (PMS2) expression and mutation in sporadic colorectal cancer (SCRC). Kaplan-Meier plots and log-rank tests were performed to conduct survival analysis and Cox proportional hazard regression models were conducted to determine independent prognostic factors. The total rate of deficient MMR (dMMR) was 14.58% (28/192): MSH6, 0.52% (1/192); PMS2, 4.17% (8/192); MSH2/MSH6, 3.65% (7/192); and MLH1/PMS2, 6.25% (12/192). The dMMR group had a significantly longer overall survival time compared with proficient MMR (pMMR) group (P=0.017). Disease-free survival time of dMMR group was also longer than pMMR group (P=0.027). Multivariate analysis using the Cox regression model confirmed that MMR status was an independent prognostic factor for SCRC. Loss of MMR expression was indicative of a favorable outcome for patients with SCRC, and MMR status could be viewed as an independent prognostic factor.</description><identifier>ISSN: 1792-1074</identifier><identifier>EISSN: 1792-1082</identifier><identifier>DOI: 10.3892/ol.2018.8192</identifier><identifier>PMID: 29725427</identifier><language>eng</language><publisher>Greece: Spandidos Publications</publisher><subject>Age ; Cancer therapies ; Care and treatment ; Colorectal cancer ; Confidence intervals ; Deoxyribonucleic acid ; Development and progression ; DNA ; Gene expression ; Genes ; Genetic aspects ; Genomes ; Health aspects ; Immunoglobulins ; Lymphatic system ; Medical prognosis ; Metastasis ; Mortality ; Multivariate analysis ; Oncogenes ; Oncology ; Population ; Protein expression ; Proteins ; Surgery ; Tumors</subject><ispartof>Oncology letters, 2018-05, Vol.15 (5), p.7007-7013</ispartof><rights>COPYRIGHT 2018 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2018</rights><rights>Copyright: © Gong et al. 2018</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-bf8ac8b16fa2c3f8813ebaa85a5e2b7deef53d81e1c907d41a6917387712bc973</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920361/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920361/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29725427$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gong, Qing</creatorcontrib><creatorcontrib>Zhang, Huan-Hu</creatorcontrib><creatorcontrib>Sun, Sheng-Bo</creatorcontrib><creatorcontrib>Ge, Wen-Min</creatorcontrib><creatorcontrib>Li, Yue</creatorcontrib><creatorcontrib>Zhu, Yong-Cun</creatorcontrib><creatorcontrib>Li, Le-Ping</creatorcontrib><title>Mismatch repair-deficient status associates with favorable prognosis of Eastern Chinese population with sporadic colorectal cancer</title><title>Oncology letters</title><addtitle>Oncol Lett</addtitle><description>The present study aimed to investigate the expression level of DNA mismatch repair gene (MMR) in in sporadic colorectal cancer (SCRC) in eastern China, and to investigate the association between MMR status and prognosis of patients with SCRC. Patient archives from the Department of Gastrointestinal Surgery of Weihai Municipal Hospital (Weihai, China) were retrospectively collected between January 2011 and January 2012. Of the 221 consecutive patients identified, 192 patients who met the criterion were deemed eligible for inclusion. Immunohistochemistry (IHC) was conducted to detect the expression of MMR proteins MutL homolog 1 (MLH1), MutS homolog 2 (MSH2), MSH6 and PMS1 homolog 2, mismatch repair system component (PMS2) expression and mutation in sporadic colorectal cancer (SCRC). Kaplan-Meier plots and log-rank tests were performed to conduct survival analysis and Cox proportional hazard regression models were conducted to determine independent prognostic factors. The total rate of deficient MMR (dMMR) was 14.58% (28/192): MSH6, 0.52% (1/192); PMS2, 4.17% (8/192); MSH2/MSH6, 3.65% (7/192); and MLH1/PMS2, 6.25% (12/192). The dMMR group had a significantly longer overall survival time compared with proficient MMR (pMMR) group (P=0.017). Disease-free survival time of dMMR group was also longer than pMMR group (P=0.027). Multivariate analysis using the Cox regression model confirmed that MMR status was an independent prognostic factor for SCRC. Loss of MMR expression was indicative of a favorable outcome for patients with SCRC, and MMR status could be viewed as an independent prognostic factor.</description><subject>Age</subject><subject>Cancer therapies</subject><subject>Care and treatment</subject><subject>Colorectal cancer</subject><subject>Confidence intervals</subject><subject>Deoxyribonucleic acid</subject><subject>Development and progression</subject><subject>DNA</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genomes</subject><subject>Health aspects</subject><subject>Immunoglobulins</subject><subject>Lymphatic system</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>Mortality</subject><subject>Multivariate analysis</subject><subject>Oncogenes</subject><subject>Oncology</subject><subject>Population</subject><subject>Protein expression</subject><subject>Proteins</subject><subject>Surgery</subject><subject>Tumors</subject><issn>1792-1074</issn><issn>1792-1082</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkk1v1DAQhiMEolXpjTOyhIQ4kCV2vpwLUrUqH1IRFzhbE2eyceW1g8cp4sovx9GWpYuwD7Y8zzu2Z94se86LTSk78dbbjSi43EjeiUfZOW87kfNCisfHfVudZZdEt0UadcOlbJ5mZ6JrRV2J9jz79dnQHqKeWMAZTMgHHI026CKjCHEhBkReG4hI7IeJExvhzgfoLbI5-J3zZIj5kV0DRQyObSfjkFLQz4uFaLw7yGhOqsFopr31AXUEyzQ4jeFZ9mQES3h5v15k395ff91-zG--fPi0vbrJdc2LmPejBC173owgdDlKyUvsAWQNNYq-HRDHuhwkR667oh0qDk3H21K2LRe97tryInt3yDsv_R4Hnf4YwKo5mD2En8qDUacRZya183eq7kRRNjwleH2fIPjvC1JUe0MarQWHfiGVqFpUQtYioS__QW_9Elz6XqIqwevUh-4vtQOLyrjRp3v1mlRdpfbIIr1eJmrzHyrNAfdGe5cals5PBK8eCCYEGyfydlmbQafgmwOogycKOB6LwQu1-kt5q1Z_qdVfCX_xsIBH-I-byt8TGMzh</recordid><startdate>20180501</startdate><enddate>20180501</enddate><creator>Gong, Qing</creator><creator>Zhang, Huan-Hu</creator><creator>Sun, Sheng-Bo</creator><creator>Ge, Wen-Min</creator><creator>Li, Yue</creator><creator>Zhu, Yong-Cun</creator><creator>Li, Le-Ping</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. Spandidos</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180501</creationdate><title>Mismatch repair-deficient status associates with favorable prognosis of Eastern Chinese population with sporadic colorectal cancer</title><author>Gong, Qing ; Zhang, Huan-Hu ; Sun, Sheng-Bo ; Ge, Wen-Min ; Li, Yue ; Zhu, Yong-Cun ; Li, Le-Ping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c510t-bf8ac8b16fa2c3f8813ebaa85a5e2b7deef53d81e1c907d41a6917387712bc973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Age</topic><topic>Cancer therapies</topic><topic>Care and treatment</topic><topic>Colorectal cancer</topic><topic>Confidence intervals</topic><topic>Deoxyribonucleic acid</topic><topic>Development and progression</topic><topic>DNA</topic><topic>Gene expression</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genomes</topic><topic>Health aspects</topic><topic>Immunoglobulins</topic><topic>Lymphatic system</topic><topic>Medical prognosis</topic><topic>Metastasis</topic><topic>Mortality</topic><topic>Multivariate analysis</topic><topic>Oncogenes</topic><topic>Oncology</topic><topic>Population</topic><topic>Protein expression</topic><topic>Proteins</topic><topic>Surgery</topic><topic>Tumors</topic><toplevel>online_resources</toplevel><creatorcontrib>Gong, Qing</creatorcontrib><creatorcontrib>Zhang, Huan-Hu</creatorcontrib><creatorcontrib>Sun, Sheng-Bo</creatorcontrib><creatorcontrib>Ge, Wen-Min</creatorcontrib><creatorcontrib>Li, Yue</creatorcontrib><creatorcontrib>Zhu, Yong-Cun</creatorcontrib><creatorcontrib>Li, Le-Ping</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oncology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gong, Qing</au><au>Zhang, Huan-Hu</au><au>Sun, Sheng-Bo</au><au>Ge, Wen-Min</au><au>Li, Yue</au><au>Zhu, Yong-Cun</au><au>Li, Le-Ping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mismatch repair-deficient status associates with favorable prognosis of Eastern Chinese population with sporadic colorectal cancer</atitle><jtitle>Oncology letters</jtitle><addtitle>Oncol Lett</addtitle><date>2018-05-01</date><risdate>2018</risdate><volume>15</volume><issue>5</issue><spage>7007</spage><epage>7013</epage><pages>7007-7013</pages><issn>1792-1074</issn><eissn>1792-1082</eissn><abstract>The present study aimed to investigate the expression level of DNA mismatch repair gene (MMR) in in sporadic colorectal cancer (SCRC) in eastern China, and to investigate the association between MMR status and prognosis of patients with SCRC. Patient archives from the Department of Gastrointestinal Surgery of Weihai Municipal Hospital (Weihai, China) were retrospectively collected between January 2011 and January 2012. Of the 221 consecutive patients identified, 192 patients who met the criterion were deemed eligible for inclusion. Immunohistochemistry (IHC) was conducted to detect the expression of MMR proteins MutL homolog 1 (MLH1), MutS homolog 2 (MSH2), MSH6 and PMS1 homolog 2, mismatch repair system component (PMS2) expression and mutation in sporadic colorectal cancer (SCRC). Kaplan-Meier plots and log-rank tests were performed to conduct survival analysis and Cox proportional hazard regression models were conducted to determine independent prognostic factors. The total rate of deficient MMR (dMMR) was 14.58% (28/192): MSH6, 0.52% (1/192); PMS2, 4.17% (8/192); MSH2/MSH6, 3.65% (7/192); and MLH1/PMS2, 6.25% (12/192). The dMMR group had a significantly longer overall survival time compared with proficient MMR (pMMR) group (P=0.017). Disease-free survival time of dMMR group was also longer than pMMR group (P=0.027). Multivariate analysis using the Cox regression model confirmed that MMR status was an independent prognostic factor for SCRC. Loss of MMR expression was indicative of a favorable outcome for patients with SCRC, and MMR status could be viewed as an independent prognostic factor.</abstract><cop>Greece</cop><pub>Spandidos Publications</pub><pmid>29725427</pmid><doi>10.3892/ol.2018.8192</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | Spandidos Publications Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Age Cancer therapies Care and treatment Colorectal cancer Confidence intervals Deoxyribonucleic acid Development and progression DNA Gene expression Genes Genetic aspects Genomes Health aspects Immunoglobulins Lymphatic system Medical prognosis Metastasis Mortality Multivariate analysis Oncogenes Oncology Population Protein expression Proteins Surgery Tumors |
| title | Mismatch repair-deficient status associates with favorable prognosis of Eastern Chinese population with sporadic colorectal cancer |
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