4-Methylumbelliferone inhibits enhanced hyaluronan synthesis and cell migration in pancreatic cancer cells in response to tumor-stromal interactions

Hyaluronic acid (HA) in tumor stroma promotes tumor invasion and progression. 4-Methylumbelliferone (4-MU) is a potent HA synthesis inhibitor. In the present study, the effects of 4-MU on enhanced HA synthesis and cell migration in pancreatic ductal adenocarcinoma (PDAC) cells, in response to co-cul...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Oncology letters 2018-05, Vol.15 (5), p.6297-6301
Hauptverfasser:	Cheng, Xiao-Bo, Sato, Norihiro, Kohi, Shiro, Koga, Atsuhiro, Hirata, Keiji
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Cancer therapies Care and treatment Cell adhesion & migration Coumarins Development and progression Fibroblasts Health aspects Hyaluronic acid Medical prognosis Motility Oncology Pancreatic cancer Pore size Studies
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!