Skin infection boosts memory B-cells specific for a cryptic vaccine epitope of group A streptococcus and broadens the immune response to enhance vaccine efficacy

Antigenic diversity of the M protein is a major constraint to the development of immunity to group A streptococcus (GAS). We demonstrate that a conserved cryptic epitope that is unrecognized by the host immune system following infection can protect mice following vaccination, and that immunity is st...

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Veröffentlicht in:	npj vaccines 2018-04, Vol.3 (1), p.15-15, Article 15
Hauptverfasser:	Pandey, Manisha, Ozberk, Victoria, Langshaw, Emma L., Calcutt, Ainslie, Powell, Jessica, Batzloff, Michael R., Rivera-Hernandez, Tania, Good, Michael F.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/590/2294 692/308/1426 Biomedical and Life Sciences Biomedicine Brief Communication Immune system Infectious Diseases Medical Microbiology Public Health Skin diseases Streptococcus infections Vaccine Vaccines Virology
Online-Zugang:	Volltext
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