Role of proNGF/p75 signaling in bladder dysfunction after spinal cord injury

Loss of bladder control is a challenging outcome facing patients with spinal cord injury (SCI). We report that systemic blocking of pro-nerve growth factor (proNGF) signaling through p75 with a CNS-penetrating small-molecule p75 inhibitor resulted in significant improvement in bladder function after...

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Veröffentlicht in:	The Journal of clinical investigation 2018-05, Vol.128 (5), p.1772-1786
Hauptverfasser:	Ryu, Jae Cheon, Tooke, Katharine, Malley, Susan E, Soulas, Anastasia, Weiss, Tirzah, Ganesh, Nisha, Saidi, Nabila, Daugherty, Stephanie, Saragovi, Uri, Ikeda, Youko, Zabbarova, Irina, Kanai, Anthony J, Yoshiyama, Mitsuharu, Farhadi, H Francis, de Groat, William C, Vizzard, Margaret A, Yoon, Sung Ok
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biomedical research Bladder Bladder diseases Central nervous system Complications and side effects Development and progression Female Gene Deletion Growth factor receptors Growth factors Health aspects Humans Hydroxylase Hyperplasia Hypertrophy Male Mice Mice, Knockout Morphology Nerve growth factor Nerve Growth Factor - genetics Nerve Growth Factor - metabolism Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Nervous system Physiological aspects Protein Precursors - genetics Protein Precursors - metabolism Receptors, Nerve Growth Factor - genetics Receptors, Nerve Growth Factor - metabolism Recovery of function Risk factors Rodents Roles Signal Transduction Spinal cord injuries Spinal Cord Injuries - complications Spinal Cord Injuries - genetics Spinal Cord Injuries - metabolism Spinal Cord Injuries - pathology Tyrosine 3-monooxygenase Urinary Bladder - metabolism Urinary Bladder - pathology Urinary Bladder Diseases - etiology Urinary Bladder Diseases - genetics Urinary Bladder Diseases - metabolism Urinary Bladder Diseases - pathology Urination Urine Urogenital system Urothelium Urothelium - metabolism Urothelium - pathology
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