Autonomous Expressions of Cytokine Genes by Human Lung Cancer Cells and Their Paracrine Regulation

Cell‐to‐cell interaction between tumors and host inflammatory cells is important for the subsequent cancer progression or regression. We examined the expressions of mRNAs for various proinflammatory cytokines by nine human lung cancer cell lines and the influences of cytokines on their gene expressi...

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Veröffentlicht in:	Cancer science 1994-02, Vol.85 (2), p.179-186
Hauptverfasser:	Mizuno, Kazuto, Sone, Saburo, Orino, Etsuko, Nii, Akihiko, Ogura, Takeshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - immunology Adenocarcinoma - metabolism Aged Autoradiography Biological and medical sciences Blotting, Northern Carcinoma, Small Cell - genetics Carcinoma, Small Cell - immunology Carcinoma, Small Cell - metabolism Cerebrospinal fluid Chemokine CCL2 Chemotactic Factors - biosynthesis Chemotactic Factors - genetics Colony-stimulating factor Cytokine Cytokines - biosynthesis Cytokines - genetics Cytokines - immunology Gene Expression Regulation, Neoplastic Granulocyte-Macrophage Colony-Stimulating Factor - biosynthesis Granulocyte-Macrophage Colony-Stimulating Factor - genetics Humans IL‐1, Paracrine Inflammation Interleukin 6 Interleukin-1 - biosynthesis Interleukin-1 - genetics Interleukin-1 - pharmacology Interleukin-6 - biosynthesis Interleukin-6 - genetics Leukocytes (granulocytic) Lung cancer Lung Neoplasms - genetics Lung Neoplasms - immunology Lung Neoplasms - metabolism Lymphocytes, Tumor-Infiltrating - immunology Macrophages Macrophages - metabolism Male Medical sciences Middle Aged Monocyte chemoattractant protein 1 Monocytes mRNA Paracrine signalling Pneumology Receptors, Granulocyte Colony-Stimulating Factor RNA, Messenger - analysis TNF‐α Tumor cell lines Tumor Cells, Cultured - immunology Tumor Cells, Cultured - metabolism Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - pharmacology Tumor necrosis factor-TNF Tumor necrosis factor-α Tumors of the respiratory system and mediastinum Up-Regulation
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