High Frequency of Thyroid Tumor Induction by N‐Methyl‐N′‐nitro‐N‐nitrosoguanidine in the Hermaphroditic Fish Rivulus marmoratus
In the self‐fertilizing hermaphroditic fish, Rivulus marmoratus, the susceptibility to tumor induction by N‐methyl‐N‐nitro‐N‐nitrosoguanidine(MNNG) was evaluated. Seven‐day‐old fish larvaewere exposed for 2 h toMNNG at concentrations ranging from 5 to 25 ppm in a static water bath. The exposed fish...
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| Veröffentlicht in: | Cancer science 1993-06, Vol.84 (6), p.608-615 |
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| creator | Park, Eun‐Ho Chang, Hwa‐Hyoung Lee, Kyoung‐Charn Kweon, Hee‐Seok Heo, Ok‐Soon Ha, Kwang‐Won |
| description | In the self‐fertilizing hermaphroditic fish, Rivulus marmoratus, the susceptibility to tumor induction by N‐methyl‐N‐nitro‐N‐nitrosoguanidine(MNNG) was evaluated. Seven‐day‐old fish larvaewere exposed for 2 h toMNNG at concentrations ranging from 5 to 25 ppm in a static water bath. The exposed fish were observed at 2 and 4 monthsafter carcinogen treatmentto assess tumor development. Within 4‐ months after25 ppmMNNG exposure, nearly all fish developed thyroid tumors. The tumor incidenceswere dose‐ and time‐dependent, and the latent period of tumor induction was less than 2 months. Most induced neoplasms were papillary carcinomas similar histologically to those of rodents and humans, and the tumors were serially transplantable to other fish of the same species. These results demonstratethat rivulus could be useful as a model of thyroid carcinogenesis. |
| doi_str_mv | 10.1111/j.1349-7006.1993.tb02020.x |
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Seven‐day‐old fish larvaewere exposed for 2 h toMNNG at concentrations ranging from 5 to 25 ppm in a static water bath. The exposed fish were observed at 2 and 4 monthsafter carcinogen treatmentto assess tumor development. Within 4‐ months after25 ppmMNNG exposure, nearly all fish developed thyroid tumors. The tumor incidenceswere dose‐ and time‐dependent, and the latent period of tumor induction was less than 2 months. Most induced neoplasms were papillary carcinomas similar histologically to those of rodents and humans, and the tumors were serially transplantable to other fish of the same species. These results demonstratethat rivulus could be useful as a model of thyroid carcinogenesis.</description><identifier>ISSN: 0910-5050</identifier><identifier>ISSN: 1347-9032</identifier><identifier>EISSN: 1349-7006</identifier><identifier>EISSN: 1876-4673</identifier><identifier>DOI: 10.1111/j.1349-7006.1993.tb02020.x</identifier><identifier>PMID: 8340250</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Carcinogenesis ; Carcinoma ; Dose-Response Relationship, Drug ; Fishes ; Freshwater ; Hermaphroditic fish ; Hermaphroditism ; Latent period ; Methylnitronitrosoguanidine - toxicity ; MNNG ; Neoplasm Transplantation ; Rivulus marmoratus ; Thyroid ; Thyroid Neoplasms - chemically induced ; Thyroid Neoplasms - pathology ; Thyroid tumor ; Tumors</subject><ispartof>Cancer science, 1993-06, Vol.84 (6), p.608-615</ispartof><rights>Copyright John Wiley & Sons, Inc. Jun 1993</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4508-f801d0e303b372abfbbe27432280d0faf4732498dcf90e9afe9db6a448714f813</citedby><cites>FETCH-LOGICAL-c4508-f801d0e303b372abfbbe27432280d0faf4732498dcf90e9afe9db6a448714f813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919321/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919321/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,27903,27904,45553,45554,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8340250$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Eun‐Ho</creatorcontrib><creatorcontrib>Chang, Hwa‐Hyoung</creatorcontrib><creatorcontrib>Lee, Kyoung‐Charn</creatorcontrib><creatorcontrib>Kweon, Hee‐Seok</creatorcontrib><creatorcontrib>Heo, Ok‐Soon</creatorcontrib><creatorcontrib>Ha, Kwang‐Won</creatorcontrib><title>High Frequency of Thyroid Tumor Induction by N‐Methyl‐N′‐nitro‐N‐nitrosoguanidine in the Hermaphroditic Fish Rivulus marmoratus</title><title>Cancer science</title><addtitle>Jpn J Cancer Res</addtitle><description>In the self‐fertilizing hermaphroditic fish, Rivulus marmoratus, the susceptibility to tumor induction by N‐methyl‐N‐nitro‐N‐nitrosoguanidine(MNNG) was evaluated. Seven‐day‐old fish larvaewere exposed for 2 h toMNNG at concentrations ranging from 5 to 25 ppm in a static water bath. The exposed fish were observed at 2 and 4 monthsafter carcinogen treatmentto assess tumor development. Within 4‐ months after25 ppmMNNG exposure, nearly all fish developed thyroid tumors. The tumor incidenceswere dose‐ and time‐dependent, and the latent period of tumor induction was less than 2 months. Most induced neoplasms were papillary carcinomas similar histologically to those of rodents and humans, and the tumors were serially transplantable to other fish of the same species. These results demonstratethat rivulus could be useful as a model of thyroid carcinogenesis.</description><subject>Animals</subject><subject>Carcinogenesis</subject><subject>Carcinoma</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fishes</subject><subject>Freshwater</subject><subject>Hermaphroditic fish</subject><subject>Hermaphroditism</subject><subject>Latent period</subject><subject>Methylnitronitrosoguanidine - toxicity</subject><subject>MNNG</subject><subject>Neoplasm Transplantation</subject><subject>Rivulus marmoratus</subject><subject>Thyroid</subject><subject>Thyroid Neoplasms - chemically induced</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Thyroid tumor</subject><subject>Tumors</subject><issn>0910-5050</issn><issn>1347-9032</issn><issn>1349-7006</issn><issn>1876-4673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqVUc2O0zAQjhBoKQuPgGSBtLeEsZ0_c0BaVdvtSgtIqJwtJ7EbV4ld7GTZ3Lhz2WfhkXgSHLUqPzfsw8xovvnm54uiVxgSHN6bXYJpyuICIE8wYzQZKiDhJ_ePosUp9ThaAMMQZ5DB0-iZ9zsAXEBOzqKzkqZAMlhE39d626KVk19GaeoJWYU27eSsbtBm7K1DN6YZ60Fbg6oJffj57eG9HNqpC04IfgRj9ODsITz43m5HYXSjjUTaoKGVaC1dL_ats40edI1W2rfok74bu9GjXrjQRwyjfx49UaLz8sXRnkefV1eb5Tq-_Xh9s7y8jes0gzJWJeAGJAVa0YKISlWVJEVKCSmhASVUWlCSsrKpFQPJhJKsqXKRpmWBU1Vieh69O_Dux6qXTS3N4ETH906HWSZuheZ_Z4xu-dbe8YxhRslMcHEkcDbczQ-8176WXSeMtKPnOC8xS7MiAF__A9zZ0ZmwHCeUMYYJxRBQbw-oOhzPO6lOo2Dgs-B8x2dV-awqnwXnR8H5fSh--ecyp9Kjwr-X_ao7Of0HM19eXuVQ0l9ctcQ3</recordid><startdate>199306</startdate><enddate>199306</enddate><creator>Park, Eun‐Ho</creator><creator>Chang, Hwa‐Hyoung</creator><creator>Lee, Kyoung‐Charn</creator><creator>Kweon, Hee‐Seok</creator><creator>Heo, Ok‐Soon</creator><creator>Ha, Kwang‐Won</creator><general>Blackwell Publishing Ltd</general><general>John Wiley & Sons, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope><scope>5PM</scope></search><sort><creationdate>199306</creationdate><title>High Frequency of Thyroid Tumor Induction by N‐Methyl‐N′‐nitro‐N‐nitrosoguanidine in the Hermaphroditic Fish Rivulus marmoratus</title><author>Park, Eun‐Ho ; Chang, Hwa‐Hyoung ; Lee, Kyoung‐Charn ; Kweon, Hee‐Seok ; Heo, Ok‐Soon ; Ha, Kwang‐Won</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4508-f801d0e303b372abfbbe27432280d0faf4732498dcf90e9afe9db6a448714f813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Carcinogenesis</topic><topic>Carcinoma</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fishes</topic><topic>Freshwater</topic><topic>Hermaphroditic fish</topic><topic>Hermaphroditism</topic><topic>Latent period</topic><topic>Methylnitronitrosoguanidine - toxicity</topic><topic>MNNG</topic><topic>Neoplasm Transplantation</topic><topic>Rivulus marmoratus</topic><topic>Thyroid</topic><topic>Thyroid Neoplasms - chemically induced</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Thyroid tumor</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Eun‐Ho</creatorcontrib><creatorcontrib>Chang, Hwa‐Hyoung</creatorcontrib><creatorcontrib>Lee, Kyoung‐Charn</creatorcontrib><creatorcontrib>Kweon, Hee‐Seok</creatorcontrib><creatorcontrib>Heo, Ok‐Soon</creatorcontrib><creatorcontrib>Ha, Kwang‐Won</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Eun‐Ho</au><au>Chang, Hwa‐Hyoung</au><au>Lee, Kyoung‐Charn</au><au>Kweon, Hee‐Seok</au><au>Heo, Ok‐Soon</au><au>Ha, Kwang‐Won</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High Frequency of Thyroid Tumor Induction by N‐Methyl‐N′‐nitro‐N‐nitrosoguanidine in the Hermaphroditic Fish Rivulus marmoratus</atitle><jtitle>Cancer science</jtitle><addtitle>Jpn J Cancer Res</addtitle><date>1993-06</date><risdate>1993</risdate><volume>84</volume><issue>6</issue><spage>608</spage><epage>615</epage><pages>608-615</pages><issn>0910-5050</issn><issn>1347-9032</issn><eissn>1349-7006</eissn><eissn>1876-4673</eissn><abstract>In the self‐fertilizing hermaphroditic fish, Rivulus marmoratus, the susceptibility to tumor induction by N‐methyl‐N‐nitro‐N‐nitrosoguanidine(MNNG) was evaluated. Seven‐day‐old fish larvaewere exposed for 2 h toMNNG at concentrations ranging from 5 to 25 ppm in a static water bath. The exposed fish were observed at 2 and 4 monthsafter carcinogen treatmentto assess tumor development. Within 4‐ months after25 ppmMNNG exposure, nearly all fish developed thyroid tumors. The tumor incidenceswere dose‐ and time‐dependent, and the latent period of tumor induction was less than 2 months. Most induced neoplasms were papillary carcinomas similar histologically to those of rodents and humans, and the tumors were serially transplantable to other fish of the same species. These results demonstratethat rivulus could be useful as a model of thyroid carcinogenesis.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>8340250</pmid><doi>10.1111/j.1349-7006.1993.tb02020.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0910-5050 |
| ispartof | Cancer science, 1993-06, Vol.84 (6), p.608-615 |
| issn | 0910-5050 1347-9032 1349-7006 1876-4673 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5919321 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; IngentaConnect Free/Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Carcinogenesis Carcinoma Dose-Response Relationship, Drug Fishes Freshwater Hermaphroditic fish Hermaphroditism Latent period Methylnitronitrosoguanidine - toxicity MNNG Neoplasm Transplantation Rivulus marmoratus Thyroid Thyroid Neoplasms - chemically induced Thyroid Neoplasms - pathology Thyroid tumor Tumors |
| title | High Frequency of Thyroid Tumor Induction by N‐Methyl‐N′‐nitro‐N‐nitrosoguanidine in the Hermaphroditic Fish Rivulus marmoratus |
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