Clinicopathologic characteristics associated with long-term survival in advanced epithelial ovarian cancer: an NRG Oncology/Gynecologic Oncology Group ancillary data study

•Of 3010 evaluable patients in GOG 182, 6.5% achieved long term survival (LTS) with survival >10years.•Patients requiring lower complexity surgery and those with smaller postoperative residual were more likely to achieve LTS.•Lower CA-125, absence of ascites, stage III disease, and microscopic residual were independent predictors of LTS.•Histology, preoperative disease extent, and performance status were also associated with LTS.•A predictive model using extensive clinicopathologic data achieved an AUC of 0.729. To identify clinicopathologic factors associated with 10-year overall survival in epithelial ovarian cancer (EOC) and primary peritoneal cancer (PPC), and to develop a predictive model identifying long-term survivors. Demographic, surgical, and clinicopathologic data were abstracted from GOG 182 records. The association between clinical variables and long-term survival (LTS) (>10years) was assessed using multivariable regression analysis. Bootstrap methods were used to develop predictive models from known prognostic clinical factors and predictive accuracy was quantified using optimism-adjusted area under the receiver operating characteristic curve (AUC). The analysis dataset included 3010 evaluable patients, of whom 195 survived greater than ten years. These patients were more likely to have better performance status, endometrioid histology, stage III (rather than stage IV) disease, absence of ascites, less extensive preoperative disease distribution, microscopic disease residual following cyoreduction (R0), and decreased complexity of surgery (p