Induction of Intestinal Adenocarcinomas by 2‐Amino‐l‐methyl‐6‐phenylimidazo‐[4,5‐b] pyridine in Nagase Analbuminemic Rats
2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP), the most abundant mutagenic heterocyclic amine in cooked foods, was examined for carcinogenic potential using Nagase analbuminemic rats (NARs), which are sensitive to various carcinogens. The concentration of PhIP in the diet was 0.04% at the b...
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| Veröffentlicht in: | Cancer science 1991-04, Vol.82 (4), p.363-366 |
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| creator | Ochiai, Masako Ogawa, Kumiko Wakabayashi, Keiji Sugimura, Takashi Nagase, Sumi Esumi, Hiroyasu Nagao, Minako |
| description | 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP), the most abundant mutagenic heterocyclic amine in cooked foods, was examined for carcinogenic potential using Nagase analbuminemic rats (NARs), which are sensitive to various carcinogens. The concentration of PhIP in the diet was 0.04% at the beginning of the experiment, this being subsequently gradually reduced to 0.01% to avoid severe body weight loss. Ten of 13 treated NARs developed a total of 36 intestinal tumors within the 311‐day experimental period. Among these, 22 were adenocarcinomas and 2 were adenomas of the small intestine, 4 were adenocarcinomas of the cecum and 8 were adenocarcinomas of the large intestine. The results suggest that PhIP could represent a significant risk to human populations exposed to foods containing heterocyclic amines. |
| doi_str_mv | 10.1111/j.1349-7006.1991.tb01855.x |
| format | Article |
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The concentration of PhIP in the diet was 0.04% at the beginning of the experiment, this being subsequently gradually reduced to 0.01% to avoid severe body weight loss. Ten of 13 treated NARs developed a total of 36 intestinal tumors within the 311‐day experimental period. Among these, 22 were adenocarcinomas and 2 were adenomas of the small intestine, 4 were adenocarcinomas of the cecum and 8 were adenocarcinomas of the large intestine. The results suggest that PhIP could represent a significant risk to human populations exposed to foods containing heterocyclic amines.</description><identifier>ISSN: 0910-5050</identifier><identifier>ISSN: 1347-9032</identifier><identifier>EISSN: 1349-7006</identifier><identifier>EISSN: 1876-4673</identifier><identifier>DOI: 10.1111/j.1349-7006.1991.tb01855.x</identifier><identifier>PMID: 1904414</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Amines ; Body weight ; Body weight loss ; Carcinogens ; Cecum ; Heterocyclic amine ; Heterocyclic amines ; Large intestine ; Mutagen in food ; Pyridines ; Rapid Communication ; Small intestine ; Tumors</subject><ispartof>Cancer science, 1991-04, Vol.82 (4), p.363-366</ispartof><rights>Copyright John Wiley & Sons, Inc. Apr 1991</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4323-d1176b9dd72c69e87913dd3afd4e94b3ce45ede083ec80aade210685f36f99cc3</citedby><cites>FETCH-LOGICAL-c4323-d1176b9dd72c69e87913dd3afd4e94b3ce45ede083ec80aade210685f36f99cc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918438/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918438/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,1418,27925,27926,45575,45576,53792,53794</link.rule.ids></links><search><creatorcontrib>Ochiai, Masako</creatorcontrib><creatorcontrib>Ogawa, Kumiko</creatorcontrib><creatorcontrib>Wakabayashi, Keiji</creatorcontrib><creatorcontrib>Sugimura, Takashi</creatorcontrib><creatorcontrib>Nagase, Sumi</creatorcontrib><creatorcontrib>Esumi, Hiroyasu</creatorcontrib><creatorcontrib>Nagao, Minako</creatorcontrib><title>Induction of Intestinal Adenocarcinomas by 2‐Amino‐l‐methyl‐6‐phenylimidazo‐[4,5‐b] pyridine in Nagase Analbuminemic Rats</title><title>Cancer science</title><description>2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP), the most abundant mutagenic heterocyclic amine in cooked foods, was examined for carcinogenic potential using Nagase analbuminemic rats (NARs), which are sensitive to various carcinogens. The concentration of PhIP in the diet was 0.04% at the beginning of the experiment, this being subsequently gradually reduced to 0.01% to avoid severe body weight loss. Ten of 13 treated NARs developed a total of 36 intestinal tumors within the 311‐day experimental period. Among these, 22 were adenocarcinomas and 2 were adenomas of the small intestine, 4 were adenocarcinomas of the cecum and 8 were adenocarcinomas of the large intestine. The results suggest that PhIP could represent a significant risk to human populations exposed to foods containing heterocyclic amines.</description><subject>Amines</subject><subject>Body weight</subject><subject>Body weight loss</subject><subject>Carcinogens</subject><subject>Cecum</subject><subject>Heterocyclic amine</subject><subject>Heterocyclic amines</subject><subject>Large intestine</subject><subject>Mutagen in food</subject><subject>Pyridines</subject><subject>Rapid Communication</subject><subject>Small intestine</subject><subject>Tumors</subject><issn>0910-5050</issn><issn>1347-9032</issn><issn>1349-7006</issn><issn>1876-4673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqVUU2LFDEQDaKs4-p_CHq126ST_ogHoRlWHVgURE8iIZ1U72ToTsake9325M2rv9FfYpodVjwaKF6KenlVqYfQU0pyms6LQ04ZF1lNSJVTIWg-dYQ2ZZnf3EObu9J9tCGCkqwkJXmIHsV4IITWpCrO0BkVhHPKN-jnzplZT9Y77Hu8cxPEyTo14NaA81oFbZ0fVcTdgovfP361Y8oTDilGmPbLeqlSHPfglsGO1qjvK-Ezf14m6L7g4xKssQ6wdfidulIRcJs6dHOSgtFq_EFN8TF60KshwpMTnqNPry8-bt9ml-_f7LbtZaY5K1hmKK2rThhTF7oS0NSCMmOY6g0HwTumgZdggDQMdEOUMlBQUjVlz6peCK3ZOXp1q3ucuxGMBjcFNchjsKMKi_TKyn8rzu7llb-WpaANZ00SeHYSCP7rnLYlD34O6T9RFjwtmDJRsMR6ecvSwccYoL_rQIlcPZQHuRolV6Pk6qE8eShv_s74zQ6w_MdLuW0vWMXYH0u2rGk</recordid><startdate>199104</startdate><enddate>199104</enddate><creator>Ochiai, Masako</creator><creator>Ogawa, Kumiko</creator><creator>Wakabayashi, Keiji</creator><creator>Sugimura, Takashi</creator><creator>Nagase, Sumi</creator><creator>Esumi, Hiroyasu</creator><creator>Nagao, Minako</creator><general>Blackwell Publishing Ltd</general><general>John Wiley & Sons, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>199104</creationdate><title>Induction of Intestinal Adenocarcinomas by 2‐Amino‐l‐methyl‐6‐phenylimidazo‐[4,5‐b] pyridine in Nagase Analbuminemic Rats</title><author>Ochiai, Masako ; 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The concentration of PhIP in the diet was 0.04% at the beginning of the experiment, this being subsequently gradually reduced to 0.01% to avoid severe body weight loss. Ten of 13 treated NARs developed a total of 36 intestinal tumors within the 311‐day experimental period. Among these, 22 were adenocarcinomas and 2 were adenomas of the small intestine, 4 were adenocarcinomas of the cecum and 8 were adenocarcinomas of the large intestine. The results suggest that PhIP could represent a significant risk to human populations exposed to foods containing heterocyclic amines.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>1904414</pmid><doi>10.1111/j.1349-7006.1991.tb01855.x</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0910-5050 |
| ispartof | Cancer science, 1991-04, Vol.82 (4), p.363-366 |
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| source | Access via Wiley Online Library; IngentaConnect Free/Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Amines Body weight Body weight loss Carcinogens Cecum Heterocyclic amine Heterocyclic amines Large intestine Mutagen in food Pyridines Rapid Communication Small intestine Tumors |
| title | Induction of Intestinal Adenocarcinomas by 2‐Amino‐l‐methyl‐6‐phenylimidazo‐[4,5‐b] pyridine in Nagase Analbuminemic Rats |
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