Polygodial analog induces apoptosis in LNCaP prostate cancer cells

Prostate cancer (PCa) is the second leading cause of death in American men. The chemotherapeutic treatment strategies are generally not effective and can lead to side effects. Hence, there is an urgent need to identify novel chemotherapeutic agents. The aim of this study was to synthesize and evalua...

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Veröffentlicht in:	European journal of pharmacology 2018-06, Vol.828, p.154-162
Hauptverfasser:	Dasari, Subramanyam, Samy, Angela Lincy Prem Antony, Narvekar, Parnal, Dontaraju, Venkata Satish, Dasari, Ramesh, Kornienko, Alexander, Munirathinam, Gnanasekar
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Caspase 3 - metabolism Cell Line, Tumor Cell Proliferation - drug effects DNA Damage Enzyme Activation - drug effects Humans Male Polygodial Prostate cancer Prostatic Neoplasms - pathology Reactive oxygen species Reactive Oxygen Species - metabolism Sesquiterpenes - chemistry Sesquiterpenes - pharmacology
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