Loss of Heterozygosity on Chromosome 1p in Thyroid Adenoma and Medullary Carcinoma, but not in Papillary Carcinoma
We analyzed 53 loci on 21 chromosomes other than chromosome 4 to detect possible loss of heterozygosity in 31 thyroid tumors using polymorphic DNA markers that detect allelic deletions at specific chromosomal loci. Loss of heterozygosity on chromosomes 1, 7 and 12 was detected in one follicular thyr...
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| Veröffentlicht in: | Cancer science 1991-10, Vol.82 (10), p.1097-1103 |
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| creator | Kubo, Katsuyuki Yoshimoto, Katsuhiko Yokogoshi, Yutaka Tsuyuguchi, Masaru Shiro, Shiro |
| description | We analyzed 53 loci on 21 chromosomes other than chromosome 4 to detect possible loss of heterozygosity in 31 thyroid tumors using polymorphic DNA markers that detect allelic deletions at specific chromosomal loci. Loss of heterozygosity on chromosomes 1, 7 and 12 was detected in one follicular thyroid adenoma, and on chromosome 1 in two medullary thyroid carcinomas. However, no loss of heterozygosity was detected at any of the loci examined in papillary thyroid carcinomas. These results suggest that chromosomal loss detected in thyroid adenoma is one of the signals for risk of premalignant transformation, and that inactivation of unknown genes on chromosome 1p contributes to tumorigenesis of medullary thyroid carcinoma. Some genetic changes other than chromosomal losses may participate in the tumorigenesis of papillary thyroid carcinoma. |
| doi_str_mv | 10.1111/j.1349-7006.1991.tb01763.x |
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Loss of heterozygosity on chromosomes 1, 7 and 12 was detected in one follicular thyroid adenoma, and on chromosome 1 in two medullary thyroid carcinomas. However, no loss of heterozygosity was detected at any of the loci examined in papillary thyroid carcinomas. These results suggest that chromosomal loss detected in thyroid adenoma is one of the signals for risk of premalignant transformation, and that inactivation of unknown genes on chromosome 1p contributes to tumorigenesis of medullary thyroid carcinoma. Some genetic changes other than chromosomal losses may participate in the tumorigenesis of papillary thyroid carcinoma.</description><identifier>ISSN: 0910-5050</identifier><identifier>ISSN: 1347-9032</identifier><identifier>EISSN: 1349-7006</identifier><identifier>EISSN: 1876-4673</identifier><identifier>DOI: 10.1111/j.1349-7006.1991.tb01763.x</identifier><identifier>PMID: 1683348</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adenoma ; Adenoma - genetics ; Carcinoma - genetics ; Carcinoma, Papillary - genetics ; Chromosome 1 ; Chromosome 4 ; Chromosome Deletion ; Chromosome I ; Chromosome Mapping ; Chromosomes, Human, Pair 1 ; Chromosomes, Human, Pair 12 ; Chromosomes, Human, Pair 7 ; DNA ; Genetic transformation ; Heterozygosity ; Heterozygote ; Humans ; Loss of heterozygosity ; Papillary thyroid carcinoma ; Polymorphism, Restriction Fragment Length ; Thyroid ; Thyroid gland ; Thyroid Neoplasms - genetics ; Thyroid tumor ; Tumorigenesis</subject><ispartof>Cancer science, 1991-10, Vol.82 (10), p.1097-1103</ispartof><rights>Copyright John Wiley & Sons, Inc. Oct 1991</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5657-7e1bf7089b5ce95e1d85cd9f378f3a359b508f5eb4a81685634ef4a0fd52137c3</citedby><cites>FETCH-LOGICAL-c5657-7e1bf7089b5ce95e1d85cd9f378f3a359b508f5eb4a81685634ef4a0fd52137c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918246/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918246/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,1416,27923,27924,45573,45574,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1683348$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kubo, Katsuyuki</creatorcontrib><creatorcontrib>Yoshimoto, Katsuhiko</creatorcontrib><creatorcontrib>Yokogoshi, Yutaka</creatorcontrib><creatorcontrib>Tsuyuguchi, Masaru</creatorcontrib><creatorcontrib>Shiro, Shiro</creatorcontrib><title>Loss of Heterozygosity on Chromosome 1p in Thyroid Adenoma and Medullary Carcinoma, but not in Papillary Carcinoma</title><title>Cancer science</title><addtitle>Jpn J Cancer Res</addtitle><description>We analyzed 53 loci on 21 chromosomes other than chromosome 4 to detect possible loss of heterozygosity in 31 thyroid tumors using polymorphic DNA markers that detect allelic deletions at specific chromosomal loci. Loss of heterozygosity on chromosomes 1, 7 and 12 was detected in one follicular thyroid adenoma, and on chromosome 1 in two medullary thyroid carcinomas. However, no loss of heterozygosity was detected at any of the loci examined in papillary thyroid carcinomas. These results suggest that chromosomal loss detected in thyroid adenoma is one of the signals for risk of premalignant transformation, and that inactivation of unknown genes on chromosome 1p contributes to tumorigenesis of medullary thyroid carcinoma. Some genetic changes other than chromosomal losses may participate in the tumorigenesis of papillary thyroid carcinoma.</description><subject>Adenoma</subject><subject>Adenoma - genetics</subject><subject>Carcinoma - genetics</subject><subject>Carcinoma, Papillary - genetics</subject><subject>Chromosome 1</subject><subject>Chromosome 4</subject><subject>Chromosome Deletion</subject><subject>Chromosome I</subject><subject>Chromosome Mapping</subject><subject>Chromosomes, Human, Pair 1</subject><subject>Chromosomes, Human, Pair 12</subject><subject>Chromosomes, Human, Pair 7</subject><subject>DNA</subject><subject>Genetic transformation</subject><subject>Heterozygosity</subject><subject>Heterozygote</subject><subject>Humans</subject><subject>Loss of heterozygosity</subject><subject>Papillary thyroid carcinoma</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Thyroid</subject><subject>Thyroid gland</subject><subject>Thyroid Neoplasms - genetics</subject><subject>Thyroid tumor</subject><subject>Tumorigenesis</subject><issn>0910-5050</issn><issn>1347-9032</issn><issn>1349-7006</issn><issn>1876-4673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqVUk1v1DAUtBBVWQo_AckCiRMJdvzNoWgVFYq0iB7as-UkTterJF7sBBp-PY521UIviHex9Gbe6I3nAfAaoxyner_LMaEqEwjxHCuF87FCWHCS3z0Bq3voKVghhVHGEEPPwPMYdyixEC9OwSnmkhAqVyBsfIzQt_DSjjb4X_Otj26coR9guQ2-99H3FuI9dAO83s7BuwauGzv43kAzNPCrbaauM2GGpQm1W_rvYDWNcPDjMnNl9u4R_gKctKaL9uXxPQM3ny6uy8ts8-3zl3K9yWrGmciExVUrkFQVq61iFjeS1Y1qiZAtMYSlPpItsxU1MtlhnFDbUoPahhWYiJqcgfOD7n6qetvUdhiD6fQ-uD7to71x-m9kcFt9639oprAsKE8Cb48CwX-fbBx172Jtk53B-ilqUVDFpaL_JGKOhOTFovjmEXHnpzCkX9AFRak4lTKxPhxYdUjhBNve74yRXg5A7_SSsl5S1ssB6OMB6Ls0_OpP1w-jh8QT_vGA_3Sdnf9DWZfrC4yUIL8BhhfBvw</recordid><startdate>199110</startdate><enddate>199110</enddate><creator>Kubo, Katsuyuki</creator><creator>Yoshimoto, Katsuhiko</creator><creator>Yokogoshi, Yutaka</creator><creator>Tsuyuguchi, Masaru</creator><creator>Shiro, Shiro</creator><general>Blackwell Publishing Ltd</general><general>John Wiley & Sons, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7T3</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>199110</creationdate><title>Loss of Heterozygosity on Chromosome 1p in Thyroid Adenoma and Medullary Carcinoma, but not in Papillary Carcinoma</title><author>Kubo, Katsuyuki ; Yoshimoto, Katsuhiko ; Yokogoshi, Yutaka ; Tsuyuguchi, Masaru ; Shiro, Shiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5657-7e1bf7089b5ce95e1d85cd9f378f3a359b508f5eb4a81685634ef4a0fd52137c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adenoma</topic><topic>Adenoma - genetics</topic><topic>Carcinoma - genetics</topic><topic>Carcinoma, Papillary - genetics</topic><topic>Chromosome 1</topic><topic>Chromosome 4</topic><topic>Chromosome Deletion</topic><topic>Chromosome I</topic><topic>Chromosome Mapping</topic><topic>Chromosomes, Human, Pair 1</topic><topic>Chromosomes, Human, Pair 12</topic><topic>Chromosomes, Human, Pair 7</topic><topic>DNA</topic><topic>Genetic transformation</topic><topic>Heterozygosity</topic><topic>Heterozygote</topic><topic>Humans</topic><topic>Loss of heterozygosity</topic><topic>Papillary thyroid carcinoma</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Thyroid</topic><topic>Thyroid gland</topic><topic>Thyroid Neoplasms - genetics</topic><topic>Thyroid tumor</topic><topic>Tumorigenesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kubo, Katsuyuki</creatorcontrib><creatorcontrib>Yoshimoto, Katsuhiko</creatorcontrib><creatorcontrib>Yokogoshi, Yutaka</creatorcontrib><creatorcontrib>Tsuyuguchi, Masaru</creatorcontrib><creatorcontrib>Shiro, Shiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Human Genome Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kubo, Katsuyuki</au><au>Yoshimoto, Katsuhiko</au><au>Yokogoshi, Yutaka</au><au>Tsuyuguchi, Masaru</au><au>Shiro, Shiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Loss of Heterozygosity on Chromosome 1p in Thyroid Adenoma and Medullary Carcinoma, but not in Papillary Carcinoma</atitle><jtitle>Cancer science</jtitle><addtitle>Jpn J Cancer Res</addtitle><date>1991-10</date><risdate>1991</risdate><volume>82</volume><issue>10</issue><spage>1097</spage><epage>1103</epage><pages>1097-1103</pages><issn>0910-5050</issn><issn>1347-9032</issn><eissn>1349-7006</eissn><eissn>1876-4673</eissn><abstract>We analyzed 53 loci on 21 chromosomes other than chromosome 4 to detect possible loss of heterozygosity in 31 thyroid tumors using polymorphic DNA markers that detect allelic deletions at specific chromosomal loci. Loss of heterozygosity on chromosomes 1, 7 and 12 was detected in one follicular thyroid adenoma, and on chromosome 1 in two medullary thyroid carcinomas. However, no loss of heterozygosity was detected at any of the loci examined in papillary thyroid carcinomas. These results suggest that chromosomal loss detected in thyroid adenoma is one of the signals for risk of premalignant transformation, and that inactivation of unknown genes on chromosome 1p contributes to tumorigenesis of medullary thyroid carcinoma. Some genetic changes other than chromosomal losses may participate in the tumorigenesis of papillary thyroid carcinoma.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>1683348</pmid><doi>10.1111/j.1349-7006.1991.tb01763.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cancer science, 1991-10, Vol.82 (10), p.1097-1103 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; IngentaConnect Free/Open Access Journals; Wiley Online Library All Journals; PubMed Central |
| subjects | Adenoma Adenoma - genetics Carcinoma - genetics Carcinoma, Papillary - genetics Chromosome 1 Chromosome 4 Chromosome Deletion Chromosome I Chromosome Mapping Chromosomes, Human, Pair 1 Chromosomes, Human, Pair 12 Chromosomes, Human, Pair 7 DNA Genetic transformation Heterozygosity Heterozygote Humans Loss of heterozygosity Papillary thyroid carcinoma Polymorphism, Restriction Fragment Length Thyroid Thyroid gland Thyroid Neoplasms - genetics Thyroid tumor Tumorigenesis |
| title | Loss of Heterozygosity on Chromosome 1p in Thyroid Adenoma and Medullary Carcinoma, but not in Papillary Carcinoma |
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