In vivo Antitumor Mechanism of Natural Human Tumor Necrosis Factor Involving a T Cell‐mediated Immunological Route

We have investigated the in vivo antitumor mechanism of natural human tumor necrosis factor (n‐TNF) isolated from a culture of human leukemic B cell line (BALL‐1), especially its action as an immunomodulator, and found that the in vivo antitumor effect of n‐TNF on Meth A sarcoma implanted in BALB/c...

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Veröffentlicht in:	Cancer science 1989-12, Vol.80 (12), p.1161-1164
Hauptverfasser:	Asami, Tetsuya, Imai, Meroni, Tanaka, Yasuo, Hosaka, Yoshitaka, Kato, Kazuharu, Nakamura, Norio, Horisawa, Yoshifumi, Ashida, Yoshikazu, Kanamori, Toshinori, Nobuhara, Masahiro, Kurimoto, Masashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity Animals Antitumor activity Biological and medical sciences Cell culture Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology Immunology In vivo antitumor mechanism Leukemia Lymphocytes Lymphocytes T Lymphokines, interleukins ( function, expression) Mice Mice, Inbred BALB C Monoclonal antibodies Monoclonal antibody Neoplasm Transplantation Rapid Communication Regulatory factors and their cellular receptors Sarcoma Sarcoma, Experimental - drug therapy Sarcoma, Experimental - immunology T cell subset T-Lymphocytes - immunology Tumor Cells, Cultured Tumor necrosis factor Tumor Necrosis Factor-alpha - pharmacology Tumor necrosis factor-TNF
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