Pharmacokinetic Modulation of Plasma 5‐Fluorouracil Concentrations to Potentiate the Antitumor Activity of Continuous Venous Infusion of 5‐Fluorouracil

Methods for pharmacokinetic modulation of the plasma 5‐fluorouracil (5‐FU) level to increase antitumor activity during continuous venous infusion (CVI) of low doses of 5‐FU were examined in Yoshida sarcoma‐bearing rats. These methods were additional infusion of 5‐FU for a short period (4 h) or oral...

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Veröffentlicht in:	Cancer science 1989-06, Vol.80 (6), p.509-512
Hauptverfasser:	Fujii, Setsuro, Fukushima, Masakazu, Shimamoto, Yuji, Shirasaka, Tetsuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluorouracil Animals Antineoplastic Combined Chemotherapy Protocols - therapeutic use Antitumor activity Biological and medical sciences Blood levels Circadian Rhythm - drug effects Continuous infusion Drug Synergism Fluorouracil - administration & dosage Fluorouracil - pharmacokinetics Fluorouracil - therapeutic use General pharmacology Infusions, Intravenous Kinetics Leukocyte Count Medical sciences Oral administration Pharmacokinetic modulation Pharmacokinetics Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Plasma Pyridines - administration & dosage Pyridines - pharmacology Rapid Communication Rats Sarcoma, Yoshida - drug therapy Tegafur Tegafur - administration & dosage UFT Uracil - administration & dosage Yoshida sarcoma
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