Immunoscintigraphy and Pharmacokinetics of Indium‐111‐labeled ZME‐018 Monoclonal Antibody in Patients with Malignant Melanoma

Immunoscintigraphic and pharmacokinetic characteristics of 111In‐labeled ZME‐018 monoclonal antibody were examined in 8 patients with malignant melanoma. Each patient received a single intravenous infusion of 20 mg of ZME‐018, coupled to 3 mCi of 111In without any acute toxicity. Scintigrams were ta...

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Veröffentlicht in:	Cancer science 1988-08, Vol.79 (8), p.973-981
Hauptverfasser:	Koizumi, Mitsuru, Endo, Keigo, Watanabe, Yuji, Saga, Tsuneo, Sakahara, Harumi, Konishi, Junji, Arano, Yasusi, Miyachi, Yoshiki, Kashihara‐Sawami, Mari, Imamura, Sadao
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute toxicity Adult Aged Animals Antibodies, Monoclonal - administration & dosage Biological and medical sciences Blood Bone imaging Dermatology Humans Immunoscintigraphy Indium Radioisotopes - pharmacokinetics Indium‐111 Infusions, Intravenous Intravenous administration Lesions Male Malignant melanoma Medical sciences Melanoma Melanoma - diagnostic imaging Metastases Mice Monoclonal antibodies Monoclonal antibody, ZME‐018 Patients Pentetic Acid Pharmacokinetics Radioactivity Skin cancer Spleen Tomography, Emission-Computed Tumors of the skin and soft tissue. Premalignant lesions
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