Therapeutic endocannabinoid augmentation for mood and anxiety disorders: comparative profiling of FAAH, MAGL and dual inhibitors

Recent studies have demonstrated anxiolytic potential of pharmacological endocannabinoid (eCB) augmentation approaches in a variety of preclinical models. Pharmacological inhibition of endocannabinoid-degrading enzymes, such as fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), el...

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Veröffentlicht in:	Translational psychiatry 2018-04, Vol.8 (1), p.92-14, Article 92
Hauptverfasser:	Bedse, Gaurav, Bluett, Rebecca J., Patrick, Toni A., Romness, Nicole K., Gaulden, Andrew D., Kingsley, Philip J., Plath, Niels, Marnett, Lawrence J., Patel, Sachin
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/436 631/378 64 64/60 692/699/476/1414 82/58 Amidohydrolases - antagonists & inhibitors Animals Anti-Anxiety Agents - administration & dosage Anxiety Anxiety Disorders - drug therapy Anxiety Disorders - metabolism Behavior Behavior, Animal - drug effects Behavioral Sciences Benzodioxoles - administration & dosage Biological Psychology Body Temperature Brain - drug effects Brain - metabolism Carbamates - administration & dosage Endocannabinoids - metabolism Female Locomotion - drug effects Male Maze Learning - drug effects Medicine Medicine & Public Health Mice, Inbred C57BL Mice, Inbred ICR Monoacylglycerol Lipases - antagonists & inhibitors Neurosciences Pharmacotherapy Piperazines - administration & dosage Piperidines - administration & dosage Psychiatry Pyridines - administration & dosage Stress, Psychological - prevention & control
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