Soluble guanylyl cyclase is a critical regulator of migraine-associated pain

Background Nitric oxide (NO) has been heavily implicated in migraine. Nitroglycerin is a prototypic NO-donor, and triggers migraine in humans. However, nitroglycerin also induces oxidative/nitrosative stress and is a source of peroxynitrite – factors previously linked with migraine etiology. Soluble...

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Veröffentlicht in:	Cephalalgia 2018-07, Vol.38 (8), p.1471-1484
Hauptverfasser:	Ben Aissa, Manel, Tipton, Alycia F, Bertels, Zachariah, Gandhi, Ronak, Moye, Laura S, Novack, Madeline, Bennett, Brian M, Wang, Yueting, Litosh, Vladislav, Lee, Sue H, Gaisina, Irina N, Thatcher, Gregory RJ, Pradhan, Amynah A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Antagonists - administration & dosage Adrenergic beta-Antagonists - therapeutic use Allosteric Regulation Animals Anticonvulsants - administration & dosage Anticonvulsants - therapeutic use Calcitonin Gene-Related Peptide - biosynthesis Disease Models, Animal Enzyme Inhibitors - administration & dosage Enzyme Inhibitors - metabolism Enzyme Inhibitors - therapeutic use Female Hyperalgesia - chemically induced Hyperalgesia - drug therapy Hyperalgesia - enzymology Male Mice Mice, Inbred C57BL Migraine Disorders - chemically induced Migraine Disorders - drug therapy Migraine Disorders - enzymology Migraine Disorders - etiology Molecular Targeted Therapy Nitric Oxide - adverse effects Nitric Oxide - metabolism Nitric Oxide Donors - pharmacology Nitroglycerin - pharmacology Oxadiazoles - administration & dosage Oxadiazoles - metabolism Oxadiazoles - therapeutic use Propranolol - administration & dosage Propranolol - therapeutic use Proto-Oncogene Proteins c-fos - biosynthesis Quinoxalines - administration & dosage Quinoxalines - metabolism Quinoxalines - therapeutic use Serotonin 5-HT1 Receptor Agonists - administration & dosage Serotonin 5-HT1 Receptor Agonists - therapeutic use Soluble Guanylyl Cyclase - metabolism Soluble Guanylyl Cyclase - physiology Sumatriptan - administration & dosage Sumatriptan - therapeutic use Topiramate - administration & dosage Topiramate - therapeutic use
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