THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders

There is a strong association between cannabis use and schizophrenia but the underlying cellular links are poorly understood. Neurons derived from human-induced pluripotent stem cells (hiPSCs) offer a platform for investigating both baseline and dynamic changes in human neural cells. Here, we expose...

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Veröffentlicht in:	Translational psychiatry 2018-04, Vol.8 (1), p.89-9, Article 89
Hauptverfasser:	Guennewig, Boris, Bitar, Maina, Obiorah, Ifeanyi, Hanks, James, O’Brien, Elizabeth A., Kaczorowski, Dominik C., Hurd, Yasmin L., Roussos, Panos, Brennand, Kristen J., Barry, Guy
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 38/39 38/91 631/378/340 692/699/476 Autistic Disorder - genetics Base Sequence Behavioral Sciences Biological Psychology Dronabinol - pharmacology Gene Expression Profiling Gene Expression Regulation Glutamic Acid - metabolism Humans Induced Pluripotent Stem Cells - drug effects Induced Pluripotent Stem Cells - metabolism Intellectual Disability - genetics Medicine Medicine & Public Health Mental Disorders - genetics Mitochondria - drug effects Mitochondria - metabolism Neurons - drug effects Neurons - metabolism Neurosciences Pharmacotherapy Post-Synaptic Density - metabolism Psychiatry Schizophrenia Schizophrenia - genetics Transcriptome
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