Neuroanatomic, epigenetic and genetic differences in monozygotic twins discordant for attention deficit hyperactivity disorder

The study of monozygotic twins discordant for attention deficit hyperactivity disorder can elucidate mechanisms that contribute to the disorder, which affects ~7% of children. First, using in vivo neuroanatomic imaging on 14 pairs of monozygotic twins (mean age 9.7, s.d. 1.9 years), we found that di...

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Veröffentlicht in:	Molecular psychiatry 2018-03, Vol.23 (3), p.683-690
Hauptverfasser:	Chen, Y-C, Sudre, G, Sharp, W, Donovan, F, Chandrasekharappa, S C, Hansen, N, Elnitski, L, Shaw, P
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208 631/378 692/699/476/1311 Anatomy Attention Deficit Disorder with Hyperactivity - diagnostic imaging Attention Deficit Disorder with Hyperactivity - genetics Attention Deficit Disorder with Hyperactivity - physiopathology Attention deficit hyperactivity disorder Behavioral Sciences Biological Psychology Brain Brain - anatomy & histology Brain - physiopathology Brain architecture Brain diseases Care and treatment Cerebellum Cerebellum - diagnostic imaging Cerebellum - physiology Cerebral cortex Child Children Copy number Corpus Striatum - diagnostic imaging Corpus Striatum - physiopathology Deoxyribonucleic acid Development and progression Discordance Diseases in Twins - genetics DNA DNA Methylation DNA probes Dopamine Epigenesis, Genetic - genetics Epigenetic inheritance Epigenetics Epigenomics Female Genetic aspects Genotype Health aspects Humans Male Medicine Medicine & Public Health Neostriatum Neurodevelopmental disorders Neurodevelopmental Disorders - genetics Neuroimaging Neurology Neurosciences original-article Pharmacotherapy Phenotype Probes Psychiatry Serotonin Twins Twins, Monozygotic - genetics Twins, Monozygotic - psychology γ-Aminobutyric acid
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