Longevity-Related Gene Transcriptomic Signature in Glioblastoma Multiforme
Glioblastoma multiforme (GBM) (grade IV astrocytoma) has been assumed to be the most fatal type of glioma with low survival and high recurrence rates, even after prompt surgical removal and aggressive courses of treatment. Transcriptional reprogramming to stem cell-like state could explain some of t...
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| Veröffentlicht in: | Oxidative medicine and cellular longevity 2018-01, Vol.2018 (2018), p.1-12 |
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| creator | Toraih, Eman A. Al-Ghamdi, Saleh A. Al-Qahtani, Saeed Awad M. Al Ageeli, Essam Badran, Dahlia I. Fawzy, Manal S. Helal, Ghada M. |
| description | Glioblastoma multiforme (GBM) (grade IV astrocytoma) has been assumed to be the most fatal type of glioma with low survival and high recurrence rates, even after prompt surgical removal and aggressive courses of treatment. Transcriptional reprogramming to stem cell-like state could explain some of the deregulated molecular signatures in GBM disease. The present study aimed to quantify the expression profiling of longevity-related transcriptional factors SOX2, OCT3/4, and NANOG to evaluate their diagnostic and performance values in high-grade gliomas. Forty-four specimens were obtained from glioblastoma patients (10 females and 34 males). Quantitative real-time polymerase chain reaction was applied for relative gene expression quantification. In silico network analysis was executed. NANOG and OCT3/4 mRNA expression levels were significantly downregulated while that of SOX2 was upregulated in cancer compared to noncancer tissues. Receiver operating characteristic curve analysis showed high diagnostic performance of NANOG and OCT3/4 than SOX2. However, the aberrant expressions of the genes studied were not associated with the prognostic variables in the current population. In conclusion, the current study highlighted the aberrant expression of certain longevity-associated transcription factors in glioblastoma multiforme which may direct the attention towards new strategies in the treatment of such lethal disease. |
| doi_str_mv | 10.1155/2018/8753063 |
| format | Article |
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Transcriptional reprogramming to stem cell-like state could explain some of the deregulated molecular signatures in GBM disease. The present study aimed to quantify the expression profiling of longevity-related transcriptional factors SOX2, OCT3/4, and NANOG to evaluate their diagnostic and performance values in high-grade gliomas. Forty-four specimens were obtained from glioblastoma patients (10 females and 34 males). Quantitative real-time polymerase chain reaction was applied for relative gene expression quantification. In silico network analysis was executed. NANOG and OCT3/4 mRNA expression levels were significantly downregulated while that of SOX2 was upregulated in cancer compared to noncancer tissues. Receiver operating characteristic curve analysis showed high diagnostic performance of NANOG and OCT3/4 than SOX2. However, the aberrant expressions of the genes studied were not associated with the prognostic variables in the current population. In conclusion, the current study highlighted the aberrant expression of certain longevity-associated transcription factors in glioblastoma multiforme which may direct the attention towards new strategies in the treatment of such lethal disease.</description><identifier>ISSN: 1942-0900</identifier><identifier>EISSN: 1942-0994</identifier><identifier>DOI: 10.1155/2018/8753063</identifier><identifier>PMID: 29849920</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Adult ; Analysis ; Area Under Curve ; Brain cancer ; Brain Neoplasms - genetics ; Brain Neoplasms - mortality ; Brain Neoplasms - pathology ; Cancer therapies ; Cell growth ; Chemotherapy ; Diagnosis ; Disease ; Disease-Free Survival ; DNA binding proteins ; Down-Regulation ; Epigenetics ; Female ; Gene expression ; Genes ; Glioblastoma - genetics ; Glioblastoma - mortality ; Glioblastoma - pathology ; Glioblastoma multiforme ; Humans ; Kaplan-Meier Estimate ; Linear Models ; Longevity - genetics ; Male ; Medical prognosis ; Medical research ; Medicine, Experimental ; Middle Aged ; Nanog Homeobox Protein - genetics ; Nanog Homeobox Protein - metabolism ; Neoplasm Staging ; Octamer Transcription Factor-3 - genetics ; Octamer Transcription Factor-3 - metabolism ; RNA ; ROC Curve ; SOXB1 Transcription Factors - genetics ; SOXB1 Transcription Factors - metabolism ; Stem cells ; Transcription factors ; Transcriptome ; Tumors ; Up-Regulation</subject><ispartof>Oxidative medicine and cellular longevity, 2018-01, Vol.2018 (2018), p.1-12</ispartof><rights>Copyright © 2018 Manal S. Fawzy et al.</rights><rights>COPYRIGHT 2018 John Wiley & Sons, Inc.</rights><rights>Copyright © 2018 Manal S. Fawzy et al.; This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2018 Manal S. Fawzy et al. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-6ff5dac8bc21956d1749d4318c743dbca845a9cc7715255d79b4e1573fa625fd3</citedby><cites>FETCH-LOGICAL-c499t-6ff5dac8bc21956d1749d4318c743dbca845a9cc7715255d79b4e1573fa625fd3</cites><orcidid>0000-0003-1252-8403 ; 0000-0002-8234-2674 ; 0000-0001-9267-3787</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914091/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914091/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29849920$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Bungǎu, Simona G.</contributor><contributor>Simona G Bungǎu</contributor><creatorcontrib>Toraih, Eman A.</creatorcontrib><creatorcontrib>Al-Ghamdi, Saleh A.</creatorcontrib><creatorcontrib>Al-Qahtani, Saeed Awad M.</creatorcontrib><creatorcontrib>Al Ageeli, Essam</creatorcontrib><creatorcontrib>Badran, Dahlia I.</creatorcontrib><creatorcontrib>Fawzy, Manal S.</creatorcontrib><creatorcontrib>Helal, Ghada M.</creatorcontrib><title>Longevity-Related Gene Transcriptomic Signature in Glioblastoma Multiforme</title><title>Oxidative medicine and cellular longevity</title><addtitle>Oxid Med Cell Longev</addtitle><description>Glioblastoma multiforme (GBM) (grade IV astrocytoma) has been assumed to be the most fatal type of glioma with low survival and high recurrence rates, even after prompt surgical removal and aggressive courses of treatment. Transcriptional reprogramming to stem cell-like state could explain some of the deregulated molecular signatures in GBM disease. The present study aimed to quantify the expression profiling of longevity-related transcriptional factors SOX2, OCT3/4, and NANOG to evaluate their diagnostic and performance values in high-grade gliomas. Forty-four specimens were obtained from glioblastoma patients (10 females and 34 males). Quantitative real-time polymerase chain reaction was applied for relative gene expression quantification. In silico network analysis was executed. NANOG and OCT3/4 mRNA expression levels were significantly downregulated while that of SOX2 was upregulated in cancer compared to noncancer tissues. Receiver operating characteristic curve analysis showed high diagnostic performance of NANOG and OCT3/4 than SOX2. However, the aberrant expressions of the genes studied were not associated with the prognostic variables in the current population. In conclusion, the current study highlighted the aberrant expression of certain longevity-associated transcription factors in glioblastoma multiforme which may direct the attention towards new strategies in the treatment of such lethal disease.</description><subject>Adult</subject><subject>Analysis</subject><subject>Area Under Curve</subject><subject>Brain cancer</subject><subject>Brain Neoplasms - genetics</subject><subject>Brain Neoplasms - mortality</subject><subject>Brain Neoplasms - pathology</subject><subject>Cancer therapies</subject><subject>Cell growth</subject><subject>Chemotherapy</subject><subject>Diagnosis</subject><subject>Disease</subject><subject>Disease-Free Survival</subject><subject>DNA binding proteins</subject><subject>Down-Regulation</subject><subject>Epigenetics</subject><subject>Female</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Glioblastoma - genetics</subject><subject>Glioblastoma - mortality</subject><subject>Glioblastoma - pathology</subject><subject>Glioblastoma multiforme</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Linear Models</subject><subject>Longevity - genetics</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Middle Aged</subject><subject>Nanog Homeobox Protein - genetics</subject><subject>Nanog Homeobox Protein - metabolism</subject><subject>Neoplasm Staging</subject><subject>Octamer Transcription Factor-3 - genetics</subject><subject>Octamer Transcription Factor-3 - metabolism</subject><subject>RNA</subject><subject>ROC Curve</subject><subject>SOXB1 Transcription Factors - genetics</subject><subject>SOXB1 Transcription Factors - metabolism</subject><subject>Stem cells</subject><subject>Transcription factors</subject><subject>Transcriptome</subject><subject>Tumors</subject><subject>Up-Regulation</subject><issn>1942-0900</issn><issn>1942-0994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0c1rFDEYBvAgiv3Qm2cZ8CLUsfmcTC5CKboqK4LWc8jkY5uSSbbJTKX_vRl2XasnTwnkx_Pm5QHgBYJvEWLsHEPUn_ecEdiRR-AYCYpbKAR9fLhDeAROSrmBVWCKnoIjLHoqBIbH4PM6xY2989N9-80GNVnTrGy0zVVWsejst1MavW6--01U05xt42OzCj4NQZX6pJovc5i8S3m0z8ATp0Kxz_fnKfjx4f3V5cd2_XX16fJi3eo6c2o755hRuh80RoJ1BnEqDCWo15wSM2jVU6aE1pwjhhkzXAzUIsaJUx1mzpBT8G6Xu52H0Rpt45RVkNvsR5XvZVJe_v0S_bXcpDvJBKJQoBrweh-Q0-1syyRHX7QNQUWb5iIxpFxghAmt9NU_9CbNOdb1qiIMY4i7B2qjgpU-ulTn6iVUXnQQ82XFRb3ZKZ1TKdm6w5cRlEuVcqlS7qus_OXDNQ_4d3cVnO3AtY9G_fT_GWersU790cumUJBfPeGvTg</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Toraih, Eman A.</creator><creator>Al-Ghamdi, Saleh A.</creator><creator>Al-Qahtani, Saeed Awad M.</creator><creator>Al Ageeli, Essam</creator><creator>Badran, Dahlia I.</creator><creator>Fawzy, Manal S.</creator><creator>Helal, Ghada M.</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1252-8403</orcidid><orcidid>https://orcid.org/0000-0002-8234-2674</orcidid><orcidid>https://orcid.org/0000-0001-9267-3787</orcidid></search><sort><creationdate>20180101</creationdate><title>Longevity-Related Gene Transcriptomic Signature in Glioblastoma Multiforme</title><author>Toraih, Eman A. ; Al-Ghamdi, Saleh A. ; Al-Qahtani, Saeed Awad M. ; Al Ageeli, Essam ; Badran, Dahlia I. ; Fawzy, Manal S. ; Helal, Ghada M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-6ff5dac8bc21956d1749d4318c743dbca845a9cc7715255d79b4e1573fa625fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Analysis</topic><topic>Area Under Curve</topic><topic>Brain cancer</topic><topic>Brain Neoplasms - genetics</topic><topic>Brain Neoplasms - mortality</topic><topic>Brain Neoplasms - pathology</topic><topic>Cancer therapies</topic><topic>Cell growth</topic><topic>Chemotherapy</topic><topic>Diagnosis</topic><topic>Disease</topic><topic>Disease-Free Survival</topic><topic>DNA binding proteins</topic><topic>Down-Regulation</topic><topic>Epigenetics</topic><topic>Female</topic><topic>Gene expression</topic><topic>Genes</topic><topic>Glioblastoma - genetics</topic><topic>Glioblastoma - mortality</topic><topic>Glioblastoma - pathology</topic><topic>Glioblastoma multiforme</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Linear Models</topic><topic>Longevity - genetics</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Middle Aged</topic><topic>Nanog Homeobox Protein - genetics</topic><topic>Nanog Homeobox Protein - metabolism</topic><topic>Neoplasm Staging</topic><topic>Octamer Transcription Factor-3 - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oxidative medicine and cellular longevity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Toraih, Eman A.</au><au>Al-Ghamdi, Saleh A.</au><au>Al-Qahtani, Saeed Awad M.</au><au>Al Ageeli, Essam</au><au>Badran, Dahlia I.</au><au>Fawzy, Manal S.</au><au>Helal, Ghada M.</au><au>Bungǎu, Simona G.</au><au>Simona G Bungǎu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longevity-Related Gene Transcriptomic Signature in Glioblastoma Multiforme</atitle><jtitle>Oxidative medicine and cellular longevity</jtitle><addtitle>Oxid Med Cell Longev</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>2018</volume><issue>2018</issue><spage>1</spage><epage>12</epage><pages>1-12</pages><issn>1942-0900</issn><eissn>1942-0994</eissn><abstract>Glioblastoma multiforme (GBM) (grade IV astrocytoma) has been assumed to be the most fatal type of glioma with low survival and high recurrence rates, even after prompt surgical removal and aggressive courses of treatment. Transcriptional reprogramming to stem cell-like state could explain some of the deregulated molecular signatures in GBM disease. The present study aimed to quantify the expression profiling of longevity-related transcriptional factors SOX2, OCT3/4, and NANOG to evaluate their diagnostic and performance values in high-grade gliomas. Forty-four specimens were obtained from glioblastoma patients (10 females and 34 males). Quantitative real-time polymerase chain reaction was applied for relative gene expression quantification. In silico network analysis was executed. NANOG and OCT3/4 mRNA expression levels were significantly downregulated while that of SOX2 was upregulated in cancer compared to noncancer tissues. Receiver operating characteristic curve analysis showed high diagnostic performance of NANOG and OCT3/4 than SOX2. However, the aberrant expressions of the genes studied were not associated with the prognostic variables in the current population. In conclusion, the current study highlighted the aberrant expression of certain longevity-associated transcription factors in glioblastoma multiforme which may direct the attention towards new strategies in the treatment of such lethal disease.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>29849920</pmid><doi>10.1155/2018/8753063</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-1252-8403</orcidid><orcidid>https://orcid.org/0000-0002-8234-2674</orcidid><orcidid>https://orcid.org/0000-0001-9267-3787</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Oxidative medicine and cellular longevity, 2018-01, Vol.2018 (2018), p.1-12 |
| issn | 1942-0900 1942-0994 |
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| source | MEDLINE; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection); PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Analysis Area Under Curve Brain cancer Brain Neoplasms - genetics Brain Neoplasms - mortality Brain Neoplasms - pathology Cancer therapies Cell growth Chemotherapy Diagnosis Disease Disease-Free Survival DNA binding proteins Down-Regulation Epigenetics Female Gene expression Genes Glioblastoma - genetics Glioblastoma - mortality Glioblastoma - pathology Glioblastoma multiforme Humans Kaplan-Meier Estimate Linear Models Longevity - genetics Male Medical prognosis Medical research Medicine, Experimental Middle Aged Nanog Homeobox Protein - genetics Nanog Homeobox Protein - metabolism Neoplasm Staging Octamer Transcription Factor-3 - genetics Octamer Transcription Factor-3 - metabolism RNA ROC Curve SOXB1 Transcription Factors - genetics SOXB1 Transcription Factors - metabolism Stem cells Transcription factors Transcriptome Tumors Up-Regulation |
| title | Longevity-Related Gene Transcriptomic Signature in Glioblastoma Multiforme |
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