Yoda1 analogue (Dooku1) which antagonizes Yoda1‐evoked activation of Piezo1 and aortic relaxation

Background and Purpose The mechanosensitive Piezo1 channel has important roles in vascular physiology and disease. Yoda1 is a small‐molecule agonist, but the pharmacology of these channels is otherwise limited. Experimental Approach Yoda1 analogues were generated by synthetic chemistry. Intracellula...

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Veröffentlicht in:	British journal of pharmacology 2018-05, Vol.175 (10), p.1744-1759
Hauptverfasser:	Evans, Elizabeth L, Cuthbertson, Kevin, Endesh, Naima, Rode, Baptiste, Blythe, Nicola M, Hyman, Adam J, Hall, Sally J, Gaunt, Hannah J, Ludlow, Melanie J, Foster, Richard, Beech, David J
Format:	Artikel
Sprache:	eng
Schlagworte:	Analogs Animals Antagonism Aorta Aorta, Thoracic - drug effects Aorta, Thoracic - metabolism Calcium (intracellular) Calcium influx Calcium ions Cell lines Cells, Cultured Channel gating CHO Cells Cricetulus Endothelium HEK293 Cells Humans Ion Channels - antagonists & inhibitors Ion Channels - metabolism Isometric Mice Pharmacology Pyrazine Pyrazines - chemical synthesis Pyrazines - chemistry Pyrazines - pharmacology Research Paper Research Papers Structure-Activity Relationship Thorax
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