The Role of MicroRNAs in Environmental Risk Factors, Noise-Induced Hearing Loss, and Mental Stress
MicroRNAs (miRNAs) are important regulators of gene expression and define part of the epigenetic signature. Their influence on every realm of biomedicine is established and progressively increasing. The impact of environment on human health is enormous. Among environmental risk factors impinging on...
Gespeichert in:
| Veröffentlicht in: | Antioxidants & redox signaling 2018-03, Vol.28 (9), p.773-796 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 796 |
|---|---|
| container_issue | 9 |
| container_start_page | 773 |
| container_title | Antioxidants & redox signaling |
| container_volume | 28 |
| creator | Miguel, Verónica Cui, Julia Yue Daimiel, Lidia Espinosa-Díez, Cristina Fernández-Hernando, Carlos Kavanagh, Terrance J Lamas, Santiago |
| description | MicroRNAs (miRNAs) are important regulators of gene expression and define part of the epigenetic signature. Their influence on every realm of biomedicine is established and progressively increasing. The impact of environment on human health is enormous. Among environmental risk factors impinging on quality of life are those of chemical nature (toxic chemicals, heavy metals, pollutants, and pesticides) as well as those related to everyday life such as exposure to noise or mental and psychosocial stress. Recent Advances: This review elaborates on the relationship between miRNAs and these environmental risk factors.
The most relevant facts underlying the role of miRNAs in the response to these environmental stressors, including redox regulatory changes and oxidative stress, are highlighted and discussed. In the cases wherein miRNA mutations are relevant for this response, the pertinent literature is also reviewed.
We conclude that, even though in some cases important advances have been made regarding close correlations between specific miRNAs and biological responses to environmental risk factors, a need for prospective large-cohort studies is likely necessary to establish causative roles. Antioxid. Redox Signal. 28, 773-796. |
| doi_str_mv | 10.1089/ars.2017.7175 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5911706</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2008956205</sourcerecordid><originalsourceid>FETCH-LOGICAL-c481t-cd91f666464e2a7ee9bead0af0ecb49e59924570268e89ff11c08a4e568b402a3</originalsourceid><addsrcrecordid>eNpVkc1LAzEQxYMofh-9SsCrWyfpJtm9CKXUD6gKVc8huzur0Tapybbgf2-WquhpAvPy5vF-hJwwGDAoygsT4oADUwPFlNgi-0wIlSnF5Hb_5sMMCpnvkYMY3wCAMwa7ZI8XQnJQsE-qp1ekMz9H6lt6Z-vgZ_ejSK2jE7e2wbsFus7M6czGd3pl6s6HeE7vvY2Y3bpmVWNDb9AE617o1Me0M66hd5tPj13AGI_ITmvmEY-_5yF5vpo8jW-y6cP17Xg0zeq8YF1WNyVrpZS5zJEbhVhWaBowLWBd5SWKsuS5UMBlgUXZtozVUJgchSyqHLgZHpLLje9yVS2wqVOGYOZ6GezChE_tjdX_N86-6he_1qJkTIFMBmffBsF_rDB2-s2vgkuZNYfUdd-ZSKpso0pdxRiw_b3AQPdIdEKieyS6R5L0p39j_ap_GAy_AEE_h7Q</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2008956205</pqid></control><display><type>article</type><title>The Role of MicroRNAs in Environmental Risk Factors, Noise-Induced Hearing Loss, and Mental Stress</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Miguel, Verónica ; Cui, Julia Yue ; Daimiel, Lidia ; Espinosa-Díez, Cristina ; Fernández-Hernando, Carlos ; Kavanagh, Terrance J ; Lamas, Santiago</creator><creatorcontrib>Miguel, Verónica ; Cui, Julia Yue ; Daimiel, Lidia ; Espinosa-Díez, Cristina ; Fernández-Hernando, Carlos ; Kavanagh, Terrance J ; Lamas, Santiago</creatorcontrib><description>MicroRNAs (miRNAs) are important regulators of gene expression and define part of the epigenetic signature. Their influence on every realm of biomedicine is established and progressively increasing. The impact of environment on human health is enormous. Among environmental risk factors impinging on quality of life are those of chemical nature (toxic chemicals, heavy metals, pollutants, and pesticides) as well as those related to everyday life such as exposure to noise or mental and psychosocial stress. Recent Advances: This review elaborates on the relationship between miRNAs and these environmental risk factors.
The most relevant facts underlying the role of miRNAs in the response to these environmental stressors, including redox regulatory changes and oxidative stress, are highlighted and discussed. In the cases wherein miRNA mutations are relevant for this response, the pertinent literature is also reviewed.
We conclude that, even though in some cases important advances have been made regarding close correlations between specific miRNAs and biological responses to environmental risk factors, a need for prospective large-cohort studies is likely necessary to establish causative roles. Antioxid. Redox Signal. 28, 773-796.</description><identifier>ISSN: 1523-0864</identifier><identifier>EISSN: 1557-7716</identifier><identifier>DOI: 10.1089/ars.2017.7175</identifier><identifier>PMID: 28562070</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Biocompatibility ; Chemical pollution ; Ecological risk assessment ; Environmental changes ; Environmental impact ; Environmental Pollutants - adverse effects ; Environmental risk ; Environmental stress ; Forum Review ; Gene expression ; Gene Expression Regulation - genetics ; Hearing loss ; Hearing Loss, Noise-Induced - epidemiology ; Hearing Loss, Noise-Induced - genetics ; Hearing Loss, Noise-Induced - pathology ; Heavy metals ; Humans ; MicroRNAs ; MicroRNAs - genetics ; miRNA ; Mutation ; Noise ; Oxidative stress ; Oxidative Stress - drug effects ; Oxidative Stress - genetics ; Pesticide toxicity ; Pesticides ; Pollutants ; Psychological stress ; Quality of Life ; Regulators ; Ribonucleic acid ; Risk analysis ; Risk Factors ; RNA ; Social interactions ; Stress, Psychological - chemically induced ; Stress, Psychological - epidemiology ; Stress, Psychological - genetics</subject><ispartof>Antioxidants & redox signaling, 2018-03, Vol.28 (9), p.773-796</ispartof><rights>(©) Copyright 2018, Mary Ann Liebert, Inc.</rights><rights>Copyright 2018, Mary Ann Liebert, Inc. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-cd91f666464e2a7ee9bead0af0ecb49e59924570268e89ff11c08a4e568b402a3</citedby><cites>FETCH-LOGICAL-c481t-cd91f666464e2a7ee9bead0af0ecb49e59924570268e89ff11c08a4e568b402a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,777,781,882,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28562070$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miguel, Verónica</creatorcontrib><creatorcontrib>Cui, Julia Yue</creatorcontrib><creatorcontrib>Daimiel, Lidia</creatorcontrib><creatorcontrib>Espinosa-Díez, Cristina</creatorcontrib><creatorcontrib>Fernández-Hernando, Carlos</creatorcontrib><creatorcontrib>Kavanagh, Terrance J</creatorcontrib><creatorcontrib>Lamas, Santiago</creatorcontrib><title>The Role of MicroRNAs in Environmental Risk Factors, Noise-Induced Hearing Loss, and Mental Stress</title><title>Antioxidants & redox signaling</title><addtitle>Antioxid Redox Signal</addtitle><description>MicroRNAs (miRNAs) are important regulators of gene expression and define part of the epigenetic signature. Their influence on every realm of biomedicine is established and progressively increasing. The impact of environment on human health is enormous. Among environmental risk factors impinging on quality of life are those of chemical nature (toxic chemicals, heavy metals, pollutants, and pesticides) as well as those related to everyday life such as exposure to noise or mental and psychosocial stress. Recent Advances: This review elaborates on the relationship between miRNAs and these environmental risk factors.
The most relevant facts underlying the role of miRNAs in the response to these environmental stressors, including redox regulatory changes and oxidative stress, are highlighted and discussed. In the cases wherein miRNA mutations are relevant for this response, the pertinent literature is also reviewed.
We conclude that, even though in some cases important advances have been made regarding close correlations between specific miRNAs and biological responses to environmental risk factors, a need for prospective large-cohort studies is likely necessary to establish causative roles. Antioxid. Redox Signal. 28, 773-796.</description><subject>Biocompatibility</subject><subject>Chemical pollution</subject><subject>Ecological risk assessment</subject><subject>Environmental changes</subject><subject>Environmental impact</subject><subject>Environmental Pollutants - adverse effects</subject><subject>Environmental risk</subject><subject>Environmental stress</subject><subject>Forum Review</subject><subject>Gene expression</subject><subject>Gene Expression Regulation - genetics</subject><subject>Hearing loss</subject><subject>Hearing Loss, Noise-Induced - epidemiology</subject><subject>Hearing Loss, Noise-Induced - genetics</subject><subject>Hearing Loss, Noise-Induced - pathology</subject><subject>Heavy metals</subject><subject>Humans</subject><subject>MicroRNAs</subject><subject>MicroRNAs - genetics</subject><subject>miRNA</subject><subject>Mutation</subject><subject>Noise</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Oxidative Stress - genetics</subject><subject>Pesticide toxicity</subject><subject>Pesticides</subject><subject>Pollutants</subject><subject>Psychological stress</subject><subject>Quality of Life</subject><subject>Regulators</subject><subject>Ribonucleic acid</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>RNA</subject><subject>Social interactions</subject><subject>Stress, Psychological - chemically induced</subject><subject>Stress, Psychological - epidemiology</subject><subject>Stress, Psychological - genetics</subject><issn>1523-0864</issn><issn>1557-7716</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc1LAzEQxYMofh-9SsCrWyfpJtm9CKXUD6gKVc8huzur0Tapybbgf2-WquhpAvPy5vF-hJwwGDAoygsT4oADUwPFlNgi-0wIlSnF5Hb_5sMMCpnvkYMY3wCAMwa7ZI8XQnJQsE-qp1ekMz9H6lt6Z-vgZ_ejSK2jE7e2wbsFus7M6czGd3pl6s6HeE7vvY2Y3bpmVWNDb9AE617o1Me0M66hd5tPj13AGI_ITmvmEY-_5yF5vpo8jW-y6cP17Xg0zeq8YF1WNyVrpZS5zJEbhVhWaBowLWBd5SWKsuS5UMBlgUXZtozVUJgchSyqHLgZHpLLje9yVS2wqVOGYOZ6GezChE_tjdX_N86-6he_1qJkTIFMBmffBsF_rDB2-s2vgkuZNYfUdd-ZSKpso0pdxRiw_b3AQPdIdEKieyS6R5L0p39j_ap_GAy_AEE_h7Q</recordid><startdate>20180320</startdate><enddate>20180320</enddate><creator>Miguel, Verónica</creator><creator>Cui, Julia Yue</creator><creator>Daimiel, Lidia</creator><creator>Espinosa-Díez, Cristina</creator><creator>Fernández-Hernando, Carlos</creator><creator>Kavanagh, Terrance J</creator><creator>Lamas, Santiago</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20180320</creationdate><title>The Role of MicroRNAs in Environmental Risk Factors, Noise-Induced Hearing Loss, and Mental Stress</title><author>Miguel, Verónica ; Cui, Julia Yue ; Daimiel, Lidia ; Espinosa-Díez, Cristina ; Fernández-Hernando, Carlos ; Kavanagh, Terrance J ; Lamas, Santiago</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-cd91f666464e2a7ee9bead0af0ecb49e59924570268e89ff11c08a4e568b402a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Biocompatibility</topic><topic>Chemical pollution</topic><topic>Ecological risk assessment</topic><topic>Environmental changes</topic><topic>Environmental impact</topic><topic>Environmental Pollutants - adverse effects</topic><topic>Environmental risk</topic><topic>Environmental stress</topic><topic>Forum Review</topic><topic>Gene expression</topic><topic>Gene Expression Regulation - genetics</topic><topic>Hearing loss</topic><topic>Hearing Loss, Noise-Induced - epidemiology</topic><topic>Hearing Loss, Noise-Induced - genetics</topic><topic>Hearing Loss, Noise-Induced - pathology</topic><topic>Heavy metals</topic><topic>Humans</topic><topic>MicroRNAs</topic><topic>MicroRNAs - genetics</topic><topic>miRNA</topic><topic>Mutation</topic><topic>Noise</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Oxidative Stress - genetics</topic><topic>Pesticide toxicity</topic><topic>Pesticides</topic><topic>Pollutants</topic><topic>Psychological stress</topic><topic>Quality of Life</topic><topic>Regulators</topic><topic>Ribonucleic acid</topic><topic>Risk analysis</topic><topic>Risk Factors</topic><topic>RNA</topic><topic>Social interactions</topic><topic>Stress, Psychological - chemically induced</topic><topic>Stress, Psychological - epidemiology</topic><topic>Stress, Psychological - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miguel, Verónica</creatorcontrib><creatorcontrib>Cui, Julia Yue</creatorcontrib><creatorcontrib>Daimiel, Lidia</creatorcontrib><creatorcontrib>Espinosa-Díez, Cristina</creatorcontrib><creatorcontrib>Fernández-Hernando, Carlos</creatorcontrib><creatorcontrib>Kavanagh, Terrance J</creatorcontrib><creatorcontrib>Lamas, Santiago</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Antioxidants & redox signaling</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miguel, Verónica</au><au>Cui, Julia Yue</au><au>Daimiel, Lidia</au><au>Espinosa-Díez, Cristina</au><au>Fernández-Hernando, Carlos</au><au>Kavanagh, Terrance J</au><au>Lamas, Santiago</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Role of MicroRNAs in Environmental Risk Factors, Noise-Induced Hearing Loss, and Mental Stress</atitle><jtitle>Antioxidants & redox signaling</jtitle><addtitle>Antioxid Redox Signal</addtitle><date>2018-03-20</date><risdate>2018</risdate><volume>28</volume><issue>9</issue><spage>773</spage><epage>796</epage><pages>773-796</pages><issn>1523-0864</issn><eissn>1557-7716</eissn><abstract>MicroRNAs (miRNAs) are important regulators of gene expression and define part of the epigenetic signature. Their influence on every realm of biomedicine is established and progressively increasing. The impact of environment on human health is enormous. Among environmental risk factors impinging on quality of life are those of chemical nature (toxic chemicals, heavy metals, pollutants, and pesticides) as well as those related to everyday life such as exposure to noise or mental and psychosocial stress. Recent Advances: This review elaborates on the relationship between miRNAs and these environmental risk factors.
The most relevant facts underlying the role of miRNAs in the response to these environmental stressors, including redox regulatory changes and oxidative stress, are highlighted and discussed. In the cases wherein miRNA mutations are relevant for this response, the pertinent literature is also reviewed.
We conclude that, even though in some cases important advances have been made regarding close correlations between specific miRNAs and biological responses to environmental risk factors, a need for prospective large-cohort studies is likely necessary to establish causative roles. Antioxid. Redox Signal. 28, 773-796.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>28562070</pmid><doi>10.1089/ars.2017.7175</doi><tpages>24</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1523-0864 |
| ispartof | Antioxidants & redox signaling, 2018-03, Vol.28 (9), p.773-796 |
| issn | 1523-0864 1557-7716 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5911706 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Biocompatibility Chemical pollution Ecological risk assessment Environmental changes Environmental impact Environmental Pollutants - adverse effects Environmental risk Environmental stress Forum Review Gene expression Gene Expression Regulation - genetics Hearing loss Hearing Loss, Noise-Induced - epidemiology Hearing Loss, Noise-Induced - genetics Hearing Loss, Noise-Induced - pathology Heavy metals Humans MicroRNAs MicroRNAs - genetics miRNA Mutation Noise Oxidative stress Oxidative Stress - drug effects Oxidative Stress - genetics Pesticide toxicity Pesticides Pollutants Psychological stress Quality of Life Regulators Ribonucleic acid Risk analysis Risk Factors RNA Social interactions Stress, Psychological - chemically induced Stress, Psychological - epidemiology Stress, Psychological - genetics |
| title | The Role of MicroRNAs in Environmental Risk Factors, Noise-Induced Hearing Loss, and Mental Stress |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T12%3A36%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Role%20of%20MicroRNAs%20in%20Environmental%20Risk%20Factors,%20Noise-Induced%20Hearing%20Loss,%20and%20Mental%20Stress&rft.jtitle=Antioxidants%20&%20redox%20signaling&rft.au=Miguel,%20Ver%C3%B3nica&rft.date=2018-03-20&rft.volume=28&rft.issue=9&rft.spage=773&rft.epage=796&rft.pages=773-796&rft.issn=1523-0864&rft.eissn=1557-7716&rft_id=info:doi/10.1089/ars.2017.7175&rft_dat=%3Cproquest_pubme%3E2008956205%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2008956205&rft_id=info:pmid/28562070&rfr_iscdi=true |