Heavy Consumption of Alcohol is Not Associated With Worse Outcomes in Patients With Idiosyncratic Drug-induced Liver Injury Compared to Non-Drinkers

The relationship between alcohol consumption and idiosyncratic drug-induced liver injury (DILI) is not well understood. We investigated the relationship between heavy consumption of alcohol and characteristics and outcomes of patients with DILI enrolled in the Drug-induced Liver Injury Network (DILI...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Clinical gastroenterology and hepatology 2018-05, Vol.16 (5), p.722-729.e2
Hauptverfasser: Dakhoul, Lara, Ghabril, Marwan, Gu, Jiezhun, Navarro, Victor, Chalasani, Naga, Serrano, Jose
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 729.e2
container_issue 5
container_start_page 722
container_title Clinical gastroenterology and hepatology
container_volume 16
creator Dakhoul, Lara
Ghabril, Marwan
Gu, Jiezhun
Navarro, Victor
Chalasani, Naga
Serrano, Jose
description The relationship between alcohol consumption and idiosyncratic drug-induced liver injury (DILI) is not well understood. We investigated the relationship between heavy consumption of alcohol and characteristics and outcomes of patients with DILI enrolled in the Drug-induced Liver Injury Network (DILIN) prospective study. We collected data from 1198 individuals with definite, highly likely, or probable DILI enrolled in the DILIN study from September 2004 through April 2016. At enrollment, all participants were asked about alcohol consumption; those with any alcohol consumption during previous 12 months were asked to complete the Skinner questionnaire to assess drinking history. Heavy consumption of alcohol was defined as more than 3 drinks, on average, per day by men or more than 2 drinks, on average, per day by women. Of the 601 persons who reported consuming at least 1 alcoholic drink in the preceding 12 months, 348 completed the Skinner questionnaire and 80 reported heavy consumption of alcohol. Heavy drinkers were younger (average age, 42 years) than non-drinkers (average age, 49 years) and a higher proportion were men (63% of heavy drinkers vs 35% of nondrinkers) (P < .01 for each comparison). Anabolic steroids were the most common cause of DILI among heavy drinkers (in 13% vs 2% in non-drinkers) (P < .001). Heavy drinkers had significantly higher peak serum levels of alanine aminotransferase (1323 U/L) than non-drinkers (754 U/L) (P = .02) and higher levels of bilirubin (16.1 mg/dL vs 12.7 mg/dL in non-drinkers) (P = .03) but there was no significant difference in liver-related death or liver transplantation between heavy drinkers (occurred in 10%) vs non-drinkers (occurred in 6%) (P = .18). In an analysis of data from the DILIN, we found anabolic steroids to be the most common cause of DILI in individuals who are heavy consumers of alcohol. Compared to non-drinkers, DILI was not associated with a greater proportion of liver-related deaths or liver transplantation in heavy drinkers.
doi_str_mv 10.1016/j.cgh.2017.12.036
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5911195</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1542356517315343</els_id><sourcerecordid>1989537866</sourcerecordid><originalsourceid>FETCH-LOGICAL-c451t-ef9556e16c2100d5519a9ecc3d31370128a4bcad75daa84c7fff1c42a313e26b3</originalsourceid><addsrcrecordid>eNp9Uc2O0zAQjhCIXRYegAvykUuCx4mTRkhIVRfYShXLAbRHy51MWpfELrZTqe_BA-OqZQUXTrbm-7Pny7LXwAvgUL_bFbjZFoJDU4AoeFk_ya5BViJvGqieXu6lrOVV9iKEHeeirdrmeXYl2pLXvKqus193pA9HtnA2TOM-GmeZ69l8QLd1AzOBfXGRzUNwaHSkjj2YuGUPzgdi91NEN1JgxrKvOhqyMZzxZWdcOFr0aYrs1k-b3NhuwqRfmQN5trS7yZ9Sx732aRpdyrH5rTf2B_nwMnvW6yHQq8t5k33_9PHb4i5f3X9eLuarHCsJMae-lbImqFEA552U0OqWEMuuhLLhIGa6WqPuGtlpPauw6fsesBI6wSTqdXmTfTj77qf1SB2mH3g9qL03o_ZH5bRR_yLWbNXGHZRsAaCVyeDtxcC7nxOFqEYTkIZBW3JTUNDOEquZ1XWiwpmK3oXgqX-MAa5ObaqdSm2qU5sKhEptJs2bv9_3qPhTXyK8PxMobelgyKuAqYe0aOMJo-qc-Y_9bzU-s64</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1989537866</pqid></control><display><type>article</type><title>Heavy Consumption of Alcohol is Not Associated With Worse Outcomes in Patients With Idiosyncratic Drug-induced Liver Injury Compared to Non-Drinkers</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Dakhoul, Lara ; Ghabril, Marwan ; Gu, Jiezhun ; Navarro, Victor ; Chalasani, Naga ; Serrano, Jose</creator><creatorcontrib>Dakhoul, Lara ; Ghabril, Marwan ; Gu, Jiezhun ; Navarro, Victor ; Chalasani, Naga ; Serrano, Jose ; United States Drug Induced Liver Injury Network</creatorcontrib><description>The relationship between alcohol consumption and idiosyncratic drug-induced liver injury (DILI) is not well understood. We investigated the relationship between heavy consumption of alcohol and characteristics and outcomes of patients with DILI enrolled in the Drug-induced Liver Injury Network (DILIN) prospective study. We collected data from 1198 individuals with definite, highly likely, or probable DILI enrolled in the DILIN study from September 2004 through April 2016. At enrollment, all participants were asked about alcohol consumption; those with any alcohol consumption during previous 12 months were asked to complete the Skinner questionnaire to assess drinking history. Heavy consumption of alcohol was defined as more than 3 drinks, on average, per day by men or more than 2 drinks, on average, per day by women. Of the 601 persons who reported consuming at least 1 alcoholic drink in the preceding 12 months, 348 completed the Skinner questionnaire and 80 reported heavy consumption of alcohol. Heavy drinkers were younger (average age, 42 years) than non-drinkers (average age, 49 years) and a higher proportion were men (63% of heavy drinkers vs 35% of nondrinkers) (P &lt; .01 for each comparison). Anabolic steroids were the most common cause of DILI among heavy drinkers (in 13% vs 2% in non-drinkers) (P &lt; .001). Heavy drinkers had significantly higher peak serum levels of alanine aminotransferase (1323 U/L) than non-drinkers (754 U/L) (P = .02) and higher levels of bilirubin (16.1 mg/dL vs 12.7 mg/dL in non-drinkers) (P = .03) but there was no significant difference in liver-related death or liver transplantation between heavy drinkers (occurred in 10%) vs non-drinkers (occurred in 6%) (P = .18). In an analysis of data from the DILIN, we found anabolic steroids to be the most common cause of DILI in individuals who are heavy consumers of alcohol. Compared to non-drinkers, DILI was not associated with a greater proportion of liver-related deaths or liver transplantation in heavy drinkers.</description><identifier>ISSN: 1542-3565</identifier><identifier>ISSN: 1542-7714</identifier><identifier>EISSN: 1542-7714</identifier><identifier>DOI: 10.1016/j.cgh.2017.12.036</identifier><identifier>PMID: 29306044</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Alcoholism - complications ; Chemical and Drug Induced Liver Injury - mortality ; Chemical and Drug Induced Liver Injury - pathology ; Chemical and Drug Induced Liver Injury - therapy ; Chronic DILI ; Drug Induced Liver Injury ; Drug Induced Liver Injury Network ; Humans ; Liver Function Tests ; Liver Transplantation - statistics &amp; numerical data ; Middle Aged ; Prospective Studies ; RUCAM ; Significant Alcohol Consumption ; Steroids - adverse effects ; Survival Analysis</subject><ispartof>Clinical gastroenterology and hepatology, 2018-05, Vol.16 (5), p.722-729.e2</ispartof><rights>2018 AGA Institute</rights><rights>Copyright © 2018 AGA Institute. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-ef9556e16c2100d5519a9ecc3d31370128a4bcad75daa84c7fff1c42a313e26b3</citedby><cites>FETCH-LOGICAL-c451t-ef9556e16c2100d5519a9ecc3d31370128a4bcad75daa84c7fff1c42a313e26b3</cites><orcidid>0000-0002-7779-1547</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cgh.2017.12.036$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,315,781,785,886,3551,27928,27929,45999</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29306044$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dakhoul, Lara</creatorcontrib><creatorcontrib>Ghabril, Marwan</creatorcontrib><creatorcontrib>Gu, Jiezhun</creatorcontrib><creatorcontrib>Navarro, Victor</creatorcontrib><creatorcontrib>Chalasani, Naga</creatorcontrib><creatorcontrib>Serrano, Jose</creatorcontrib><creatorcontrib>United States Drug Induced Liver Injury Network</creatorcontrib><title>Heavy Consumption of Alcohol is Not Associated With Worse Outcomes in Patients With Idiosyncratic Drug-induced Liver Injury Compared to Non-Drinkers</title><title>Clinical gastroenterology and hepatology</title><addtitle>Clin Gastroenterol Hepatol</addtitle><description>The relationship between alcohol consumption and idiosyncratic drug-induced liver injury (DILI) is not well understood. We investigated the relationship between heavy consumption of alcohol and characteristics and outcomes of patients with DILI enrolled in the Drug-induced Liver Injury Network (DILIN) prospective study. We collected data from 1198 individuals with definite, highly likely, or probable DILI enrolled in the DILIN study from September 2004 through April 2016. At enrollment, all participants were asked about alcohol consumption; those with any alcohol consumption during previous 12 months were asked to complete the Skinner questionnaire to assess drinking history. Heavy consumption of alcohol was defined as more than 3 drinks, on average, per day by men or more than 2 drinks, on average, per day by women. Of the 601 persons who reported consuming at least 1 alcoholic drink in the preceding 12 months, 348 completed the Skinner questionnaire and 80 reported heavy consumption of alcohol. Heavy drinkers were younger (average age, 42 years) than non-drinkers (average age, 49 years) and a higher proportion were men (63% of heavy drinkers vs 35% of nondrinkers) (P &lt; .01 for each comparison). Anabolic steroids were the most common cause of DILI among heavy drinkers (in 13% vs 2% in non-drinkers) (P &lt; .001). Heavy drinkers had significantly higher peak serum levels of alanine aminotransferase (1323 U/L) than non-drinkers (754 U/L) (P = .02) and higher levels of bilirubin (16.1 mg/dL vs 12.7 mg/dL in non-drinkers) (P = .03) but there was no significant difference in liver-related death or liver transplantation between heavy drinkers (occurred in 10%) vs non-drinkers (occurred in 6%) (P = .18). In an analysis of data from the DILIN, we found anabolic steroids to be the most common cause of DILI in individuals who are heavy consumers of alcohol. Compared to non-drinkers, DILI was not associated with a greater proportion of liver-related deaths or liver transplantation in heavy drinkers.</description><subject>Adult</subject><subject>Aged</subject><subject>Alcoholism - complications</subject><subject>Chemical and Drug Induced Liver Injury - mortality</subject><subject>Chemical and Drug Induced Liver Injury - pathology</subject><subject>Chemical and Drug Induced Liver Injury - therapy</subject><subject>Chronic DILI</subject><subject>Drug Induced Liver Injury</subject><subject>Drug Induced Liver Injury Network</subject><subject>Humans</subject><subject>Liver Function Tests</subject><subject>Liver Transplantation - statistics &amp; numerical data</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>RUCAM</subject><subject>Significant Alcohol Consumption</subject><subject>Steroids - adverse effects</subject><subject>Survival Analysis</subject><issn>1542-3565</issn><issn>1542-7714</issn><issn>1542-7714</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Uc2O0zAQjhCIXRYegAvykUuCx4mTRkhIVRfYShXLAbRHy51MWpfELrZTqe_BA-OqZQUXTrbm-7Pny7LXwAvgUL_bFbjZFoJDU4AoeFk_ya5BViJvGqieXu6lrOVV9iKEHeeirdrmeXYl2pLXvKqus193pA9HtnA2TOM-GmeZ69l8QLd1AzOBfXGRzUNwaHSkjj2YuGUPzgdi91NEN1JgxrKvOhqyMZzxZWdcOFr0aYrs1k-b3NhuwqRfmQN5trS7yZ9Sx732aRpdyrH5rTf2B_nwMnvW6yHQq8t5k33_9PHb4i5f3X9eLuarHCsJMae-lbImqFEA552U0OqWEMuuhLLhIGa6WqPuGtlpPauw6fsesBI6wSTqdXmTfTj77qf1SB2mH3g9qL03o_ZH5bRR_yLWbNXGHZRsAaCVyeDtxcC7nxOFqEYTkIZBW3JTUNDOEquZ1XWiwpmK3oXgqX-MAa5ObaqdSm2qU5sKhEptJs2bv9_3qPhTXyK8PxMobelgyKuAqYe0aOMJo-qc-Y_9bzU-s64</recordid><startdate>20180501</startdate><enddate>20180501</enddate><creator>Dakhoul, Lara</creator><creator>Ghabril, Marwan</creator><creator>Gu, Jiezhun</creator><creator>Navarro, Victor</creator><creator>Chalasani, Naga</creator><creator>Serrano, Jose</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7779-1547</orcidid></search><sort><creationdate>20180501</creationdate><title>Heavy Consumption of Alcohol is Not Associated With Worse Outcomes in Patients With Idiosyncratic Drug-induced Liver Injury Compared to Non-Drinkers</title><author>Dakhoul, Lara ; Ghabril, Marwan ; Gu, Jiezhun ; Navarro, Victor ; Chalasani, Naga ; Serrano, Jose</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-ef9556e16c2100d5519a9ecc3d31370128a4bcad75daa84c7fff1c42a313e26b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Alcoholism - complications</topic><topic>Chemical and Drug Induced Liver Injury - mortality</topic><topic>Chemical and Drug Induced Liver Injury - pathology</topic><topic>Chemical and Drug Induced Liver Injury - therapy</topic><topic>Chronic DILI</topic><topic>Drug Induced Liver Injury</topic><topic>Drug Induced Liver Injury Network</topic><topic>Humans</topic><topic>Liver Function Tests</topic><topic>Liver Transplantation - statistics &amp; numerical data</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>RUCAM</topic><topic>Significant Alcohol Consumption</topic><topic>Steroids - adverse effects</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dakhoul, Lara</creatorcontrib><creatorcontrib>Ghabril, Marwan</creatorcontrib><creatorcontrib>Gu, Jiezhun</creatorcontrib><creatorcontrib>Navarro, Victor</creatorcontrib><creatorcontrib>Chalasani, Naga</creatorcontrib><creatorcontrib>Serrano, Jose</creatorcontrib><creatorcontrib>United States Drug Induced Liver Injury Network</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical gastroenterology and hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dakhoul, Lara</au><au>Ghabril, Marwan</au><au>Gu, Jiezhun</au><au>Navarro, Victor</au><au>Chalasani, Naga</au><au>Serrano, Jose</au><aucorp>United States Drug Induced Liver Injury Network</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heavy Consumption of Alcohol is Not Associated With Worse Outcomes in Patients With Idiosyncratic Drug-induced Liver Injury Compared to Non-Drinkers</atitle><jtitle>Clinical gastroenterology and hepatology</jtitle><addtitle>Clin Gastroenterol Hepatol</addtitle><date>2018-05-01</date><risdate>2018</risdate><volume>16</volume><issue>5</issue><spage>722</spage><epage>729.e2</epage><pages>722-729.e2</pages><issn>1542-3565</issn><issn>1542-7714</issn><eissn>1542-7714</eissn><abstract>The relationship between alcohol consumption and idiosyncratic drug-induced liver injury (DILI) is not well understood. We investigated the relationship between heavy consumption of alcohol and characteristics and outcomes of patients with DILI enrolled in the Drug-induced Liver Injury Network (DILIN) prospective study. We collected data from 1198 individuals with definite, highly likely, or probable DILI enrolled in the DILIN study from September 2004 through April 2016. At enrollment, all participants were asked about alcohol consumption; those with any alcohol consumption during previous 12 months were asked to complete the Skinner questionnaire to assess drinking history. Heavy consumption of alcohol was defined as more than 3 drinks, on average, per day by men or more than 2 drinks, on average, per day by women. Of the 601 persons who reported consuming at least 1 alcoholic drink in the preceding 12 months, 348 completed the Skinner questionnaire and 80 reported heavy consumption of alcohol. Heavy drinkers were younger (average age, 42 years) than non-drinkers (average age, 49 years) and a higher proportion were men (63% of heavy drinkers vs 35% of nondrinkers) (P &lt; .01 for each comparison). Anabolic steroids were the most common cause of DILI among heavy drinkers (in 13% vs 2% in non-drinkers) (P &lt; .001). Heavy drinkers had significantly higher peak serum levels of alanine aminotransferase (1323 U/L) than non-drinkers (754 U/L) (P = .02) and higher levels of bilirubin (16.1 mg/dL vs 12.7 mg/dL in non-drinkers) (P = .03) but there was no significant difference in liver-related death or liver transplantation between heavy drinkers (occurred in 10%) vs non-drinkers (occurred in 6%) (P = .18). In an analysis of data from the DILIN, we found anabolic steroids to be the most common cause of DILI in individuals who are heavy consumers of alcohol. Compared to non-drinkers, DILI was not associated with a greater proportion of liver-related deaths or liver transplantation in heavy drinkers.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>29306044</pmid><doi>10.1016/j.cgh.2017.12.036</doi><orcidid>https://orcid.org/0000-0002-7779-1547</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1542-3565
ispartof Clinical gastroenterology and hepatology, 2018-05, Vol.16 (5), p.722-729.e2
issn 1542-3565
1542-7714
1542-7714
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5911195
source MEDLINE; Access via ScienceDirect (Elsevier)
subjects Adult
Aged
Alcoholism - complications
Chemical and Drug Induced Liver Injury - mortality
Chemical and Drug Induced Liver Injury - pathology
Chemical and Drug Induced Liver Injury - therapy
Chronic DILI
Drug Induced Liver Injury
Drug Induced Liver Injury Network
Humans
Liver Function Tests
Liver Transplantation - statistics & numerical data
Middle Aged
Prospective Studies
RUCAM
Significant Alcohol Consumption
Steroids - adverse effects
Survival Analysis
title Heavy Consumption of Alcohol is Not Associated With Worse Outcomes in Patients With Idiosyncratic Drug-induced Liver Injury Compared to Non-Drinkers
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-17T05%3A52%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Heavy%20Consumption%20of%20Alcohol%20is%20Not%20Associated%20With%20Worse%20Outcomes%20in%20Patients%20With%20Idiosyncratic%20Drug-induced%20Liver%20Injury%20Compared%20to%20Non-Drinkers&rft.jtitle=Clinical%20gastroenterology%20and%20hepatology&rft.au=Dakhoul,%20Lara&rft.aucorp=United%20States%20Drug%20Induced%20Liver%20Injury%20Network&rft.date=2018-05-01&rft.volume=16&rft.issue=5&rft.spage=722&rft.epage=729.e2&rft.pages=722-729.e2&rft.issn=1542-3565&rft.eissn=1542-7714&rft_id=info:doi/10.1016/j.cgh.2017.12.036&rft_dat=%3Cproquest_pubme%3E1989537866%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1989537866&rft_id=info:pmid/29306044&rft_els_id=S1542356517315343&rfr_iscdi=true