Robust, linear correlations between growth rates and β-lactam–mediated lysis rates

It is widely acknowledged that faster-growing bacteria are killed faster by β-lactam antibiotics. This notion serves as the foundation for the concept of bacterial persistence: dormant bacterial cells that do not grow are phenotypically tolerant against β-lactam treatment. Such correlation has often...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2018-04, Vol.115 (16), p.4069-4074
Hauptverfasser:	Lee, Anna J., Wang, Shangying, Meredith, Hannah R., Zhuang, Bihan, Dai, Zhuojun, You, Lingchong
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides Anti-Bacterial Agents - pharmacology Antibiotics Automation Bacteria Bacterial infections Bacterial Load Bacteriolysis - drug effects Biological Sciences Biomass Carbenicillin - pharmacology Clinical isolates Correlation analysis Culture Media - pharmacology Dependence Drug resistance Escherichia coli - drug effects Escherichia coli - growth & development Growth rate High-Throughput Screening Assays - instrumentation Kinetics Lysis Mathematical models Nephelometry and Turbidimetry Phenotypes Physical Sciences Robotics Robustness (mathematics) Temperature β-Lactam antibiotics
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