Ammonium and arsenic trioxide are potent facilitators of oligonucleotide function when delivered by gymnosis

Abstract Oligonucleotide (ON) concentrations employed for therapeutic applications vary widely, but in general are high enough to raise significant concerns for off target effects and cellular toxicity. However, lowering ON concentrations reduces the chances of a therapeutic response, since typicall...

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Veröffentlicht in:	Nucleic acids research 2018-04, Vol.46 (7), p.3612-3624
Hauptverfasser:	Zhang, Xiaowei, Castanotto, Daniela, Liu, Xueli, Shemi, Amotz, Stein, Cy A
Format:	Artikel
Sprache:	eng
Schlagworte:	Molecular Biology
Online-Zugang:	Volltext
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