Combined cistrome and transcriptome analysis of SKI in AML cells identifies SKI as a co-repressor for RUNX1

Abstract SKI is a transcriptional co-regulator and overexpressed in various human tumors, for example in acute myeloid leukemia (AML). SKI contributes to the origin and maintenance of the leukemic phenotype. Here, we use ChIP-seq and RNA-seq analysis to identify the epigenetic alterations induced by...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nucleic acids research 2018-04, Vol.46 (7), p.3412-3428
Hauptverfasser:	Feld, Christine, Sahu, Peeyush, Frech, Miriam, Finkernagel, Florian, Nist, Andrea, Stiewe, Thorsten, Bauer, Uta-Maria, Neubauer, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites - genetics Core Binding Factor Alpha 2 Subunit - genetics DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene Expression Profiling Gene Expression Regulation, Neoplastic - genetics Gene regulation, Chromatin and Epigenetics Gene Silencing Genes - genetics HL-60 Cells Humans Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - pathology Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Regulatory Elements, Transcriptional - genetics Transcriptional Activation - genetics Transcriptome - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!