Alpha-2-macroglobulin as a Promising Biological Marker of Endothelial Function
Aims: Alpha-2-macroglobulin (α2MG) is thought to be associated with inflammatory reactions and procoagulant properties that might cause ischemic stroke. Endothelial dysfunction plays an important role in atherosclerosis development and in the occurrence of cardiovascular events. In this study, we in...
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| Veröffentlicht in: | Journal of Atherosclerosis and Thrombosis 2018/04/01, Vol.25(4), pp.350-358 |
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| creator | Shimomura, Ryo Nezu, Tomohisa Hosomi, Naohisa Aoki, Shiro Sugimoto, Takamichi Kinoshita, Naoto Araki, Mutsuko Takahashi, Tetsuya Maruyama, Hirofumi Matsumoto, Masayasu |
| description | Aims: Alpha-2-macroglobulin (α2MG) is thought to be associated with inflammatory reactions and procoagulant properties that might cause ischemic stroke. Endothelial dysfunction plays an important role in atherosclerosis development and in the occurrence of cardiovascular events. In this study, we investigated whether serum α2MG levels, endothelial function, and endothelial progenitor cell (EPC) number were associated in patients with chronic stroke or cardiovascular risk factors.Methods: Patients with a history of stroke or any established cardiovascular risk factors were enrolled in this study (n=102; 69 men, 70.1±9.2 years). Endothelial function was assessed by flow-mediated dilation (FMD). EPC numbers (CD34＋/CD133＋) were measured using flow cytometry (n=91). Serum α2MG levels were measured by nephelometry.Results: Patients in the highest tertile of serum α2MG levels were older (P=0.019) and more frequently exhibited dyslipidemia (P=0.021). Univariate-regression analysis revealed that increased α2MG levels were negatively associated with FMD values (r=−0.25; P=0.010), whereas increased EPC numbers were positively associated (r=0.21; P=0.044). Multivariate-regression analysis adjusted for male gender, hypertension, and severe white-matter lesions showed that serum α2MG levels were independently associated with FMD values (standardized partial regression coefficient [β] −0.185; P=0.033), although not significantly associated with EPC numbers.Conclusion: Serum α2MG levels might reflect endothelial dysfunction evaluated by FMD in patients with chronic stroke or cardiovascular risk factors. |
| doi_str_mv | 10.5551/jat.41335 |
| format | Article |
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Endothelial dysfunction plays an important role in atherosclerosis development and in the occurrence of cardiovascular events. In this study, we investigated whether serum α2MG levels, endothelial function, and endothelial progenitor cell (EPC) number were associated in patients with chronic stroke or cardiovascular risk factors.Methods: Patients with a history of stroke or any established cardiovascular risk factors were enrolled in this study (n=102; 69 men, 70.1±9.2 years). Endothelial function was assessed by flow-mediated dilation (FMD). EPC numbers (CD34＋/CD133＋) were measured using flow cytometry (n=91). Serum α2MG levels were measured by nephelometry.Results: Patients in the highest tertile of serum α2MG levels were older (P=0.019) and more frequently exhibited dyslipidemia (P=0.021). Univariate-regression analysis revealed that increased α2MG levels were negatively associated with FMD values (r=−0.25; P=0.010), whereas increased EPC numbers were positively associated (r=0.21; P=0.044). Multivariate-regression analysis adjusted for male gender, hypertension, and severe white-matter lesions showed that serum α2MG levels were independently associated with FMD values (standardized partial regression coefficient [β] −0.185; P=0.033), although not significantly associated with EPC numbers.Conclusion: Serum α2MG levels might reflect endothelial dysfunction evaluated by FMD in patients with chronic stroke or cardiovascular risk factors.</description><identifier>ISSN: 1340-3478</identifier><identifier>EISSN: 1880-3873</identifier><identifier>DOI: 10.5551/jat.41335</identifier><identifier>PMID: 29093276</identifier><language>eng</language><publisher>Japan: Japan Atherosclerosis Society</publisher><subject>Aged ; Atherosclerosis - pathology ; Biological marker ; Biomarkers - blood ; Cardiovascular Diseases - blood ; Dyslipidemias - blood ; Endothelial dysfunction ; Endothelial progenitor cell ; Endothelial Progenitor Cells ; Endothelium, Vascular - pathology ; Female ; Flow Cytometry ; Flow-mediated dilation ; Glomerular Filtration Rate ; Humans ; Hypertension - blood ; Inflammation - pathology ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Multivariate Analysis ; Original ; Pregnancy-Associated alpha 2-Macroglobulins - analysis ; Prospective Studies ; Regression Analysis ; Risk Factors ; Stem Cells - cytology ; Stroke ; Stroke - blood ; Stroke - pathology</subject><ispartof>Journal of Atherosclerosis and Thrombosis, 2018/04/01, Vol.25(4), pp.350-358</ispartof><rights>2018 This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.</rights><rights>2018 Japan Atherosclerosis Society 2018</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c686t-ee9475a36789ccca56ec03516c8464ca0d41722bea6ae269fa326b8c4b0c9bfe3</citedby><cites>FETCH-LOGICAL-c686t-ee9475a36789ccca56ec03516c8464ca0d41722bea6ae269fa326b8c4b0c9bfe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906188/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906188/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1877,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29093276$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shimomura, Ryo</creatorcontrib><creatorcontrib>Nezu, Tomohisa</creatorcontrib><creatorcontrib>Hosomi, Naohisa</creatorcontrib><creatorcontrib>Aoki, Shiro</creatorcontrib><creatorcontrib>Sugimoto, Takamichi</creatorcontrib><creatorcontrib>Kinoshita, Naoto</creatorcontrib><creatorcontrib>Araki, Mutsuko</creatorcontrib><creatorcontrib>Takahashi, Tetsuya</creatorcontrib><creatorcontrib>Maruyama, Hirofumi</creatorcontrib><creatorcontrib>Matsumoto, Masayasu</creatorcontrib><creatorcontrib>Department of Clinical Neuroscience and Therapeutics</creatorcontrib><creatorcontrib>Hiroshima University Graduate School of Biomedical Sciences</creatorcontrib><creatorcontrib>Hoshigaoka Medical Center</creatorcontrib><creatorcontrib>Japan Community Healthcare Organization (JCHO</creatorcontrib><title>Alpha-2-macroglobulin as a Promising Biological Marker of Endothelial Function</title><title>Journal of Atherosclerosis and Thrombosis</title><addtitle>JAT</addtitle><description>Aims: Alpha-2-macroglobulin (α2MG) is thought to be associated with inflammatory reactions and procoagulant properties that might cause ischemic stroke. Endothelial dysfunction plays an important role in atherosclerosis development and in the occurrence of cardiovascular events. In this study, we investigated whether serum α2MG levels, endothelial function, and endothelial progenitor cell (EPC) number were associated in patients with chronic stroke or cardiovascular risk factors.Methods: Patients with a history of stroke or any established cardiovascular risk factors were enrolled in this study (n=102; 69 men, 70.1±9.2 years). Endothelial function was assessed by flow-mediated dilation (FMD). EPC numbers (CD34＋/CD133＋) were measured using flow cytometry (n=91). Serum α2MG levels were measured by nephelometry.Results: Patients in the highest tertile of serum α2MG levels were older (P=0.019) and more frequently exhibited dyslipidemia (P=0.021). Univariate-regression analysis revealed that increased α2MG levels were negatively associated with FMD values (r=−0.25; P=0.010), whereas increased EPC numbers were positively associated (r=0.21; P=0.044). Multivariate-regression analysis adjusted for male gender, hypertension, and severe white-matter lesions showed that serum α2MG levels were independently associated with FMD values (standardized partial regression coefficient [β] −0.185; P=0.033), although not significantly associated with EPC numbers.Conclusion: Serum α2MG levels might reflect endothelial dysfunction evaluated by FMD in patients with chronic stroke or cardiovascular risk factors.</description><subject>Aged</subject><subject>Atherosclerosis - pathology</subject><subject>Biological marker</subject><subject>Biomarkers - blood</subject><subject>Cardiovascular Diseases - blood</subject><subject>Dyslipidemias - blood</subject><subject>Endothelial dysfunction</subject><subject>Endothelial progenitor cell</subject><subject>Endothelial Progenitor Cells</subject><subject>Endothelium, Vascular - pathology</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Flow-mediated dilation</subject><subject>Glomerular Filtration Rate</subject><subject>Humans</subject><subject>Hypertension - blood</subject><subject>Inflammation - pathology</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Original</subject><subject>Pregnancy-Associated alpha 2-Macroglobulins - analysis</subject><subject>Prospective Studies</subject><subject>Regression Analysis</subject><subject>Risk Factors</subject><subject>Stem Cells - cytology</subject><subject>Stroke</subject><subject>Stroke - blood</subject><subject>Stroke - pathology</subject><issn>1340-3478</issn><issn>1880-3873</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1v1DAQhiMEoqVw4A-gHOGQ4u84F1Cp2oJUPg5wtibeSdaL197aCaL_Hme3rOAyM_K8euf1U1UvKTmXUtK3G5jOBeVcPqpOqdak4brlj8vMRZlFq0-qZzlvCCkSyZ5WJ6wjHWetOq2-XPjdGhrWbMGmOPrYz96FGnIN9bcUty67MNYfXPRxdBZ8_RnST0x1HOqrsIrTGr0rr9dzsJOL4Xn1ZACf8cVDP6t-XF99v_zY3H69-XR5cdtYpdXUIHailcBVqztrLUiFlnBJldVCCQtkJWjLWI-gAJnqBuBM9dqKntiuH5CfVe8Ovru53-LKYpgSeLNLbgvp3kRw5v9NcGszxl9GdkQVRMXg9YNBincz5smUr1r0HgLGORvayUJItHyRvjlIC6CcEw7HM5SYhb8p_M2ef9G--jfXUfkXeBHcHARlu_CMoeBGs4lzCgWYwd_tKm7vwTBCtSGESSJK60zBQ5aiOdFcK1qc3h-cNnmCEY-nIE3OetyHYtKIfVnCHTd2Dclg4H8A05ivKQ</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Shimomura, Ryo</creator><creator>Nezu, Tomohisa</creator><creator>Hosomi, Naohisa</creator><creator>Aoki, Shiro</creator><creator>Sugimoto, Takamichi</creator><creator>Kinoshita, Naoto</creator><creator>Araki, Mutsuko</creator><creator>Takahashi, Tetsuya</creator><creator>Maruyama, Hirofumi</creator><creator>Matsumoto, Masayasu</creator><general>Japan Atherosclerosis Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180101</creationdate><title>Alpha-2-macroglobulin as a Promising Biological Marker of Endothelial Function</title><author>Shimomura, Ryo ; Nezu, Tomohisa ; Hosomi, Naohisa ; Aoki, Shiro ; Sugimoto, Takamichi ; Kinoshita, Naoto ; Araki, Mutsuko ; Takahashi, Tetsuya ; Maruyama, Hirofumi ; Matsumoto, Masayasu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c686t-ee9475a36789ccca56ec03516c8464ca0d41722bea6ae269fa326b8c4b0c9bfe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Atherosclerosis - pathology</topic><topic>Biological marker</topic><topic>Biomarkers - blood</topic><topic>Cardiovascular Diseases - blood</topic><topic>Dyslipidemias - blood</topic><topic>Endothelial dysfunction</topic><topic>Endothelial progenitor cell</topic><topic>Endothelial Progenitor Cells</topic><topic>Endothelium, Vascular - pathology</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Flow-mediated dilation</topic><topic>Glomerular Filtration Rate</topic><topic>Humans</topic><topic>Hypertension - blood</topic><topic>Inflammation - pathology</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Original</topic><topic>Pregnancy-Associated alpha 2-Macroglobulins - analysis</topic><topic>Prospective Studies</topic><topic>Regression Analysis</topic><topic>Risk Factors</topic><topic>Stem Cells - cytology</topic><topic>Stroke</topic><topic>Stroke - blood</topic><topic>Stroke - pathology</topic><toplevel>online_resources</toplevel><creatorcontrib>Shimomura, Ryo</creatorcontrib><creatorcontrib>Nezu, Tomohisa</creatorcontrib><creatorcontrib>Hosomi, Naohisa</creatorcontrib><creatorcontrib>Aoki, Shiro</creatorcontrib><creatorcontrib>Sugimoto, Takamichi</creatorcontrib><creatorcontrib>Kinoshita, Naoto</creatorcontrib><creatorcontrib>Araki, Mutsuko</creatorcontrib><creatorcontrib>Takahashi, Tetsuya</creatorcontrib><creatorcontrib>Maruyama, Hirofumi</creatorcontrib><creatorcontrib>Matsumoto, Masayasu</creatorcontrib><creatorcontrib>Department of Clinical Neuroscience and Therapeutics</creatorcontrib><creatorcontrib>Hiroshima University Graduate School of Biomedical Sciences</creatorcontrib><creatorcontrib>Hoshigaoka Medical Center</creatorcontrib><creatorcontrib>Japan Community Healthcare Organization (JCHO</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Atherosclerosis and Thrombosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shimomura, Ryo</au><au>Nezu, Tomohisa</au><au>Hosomi, Naohisa</au><au>Aoki, Shiro</au><au>Sugimoto, Takamichi</au><au>Kinoshita, Naoto</au><au>Araki, Mutsuko</au><au>Takahashi, Tetsuya</au><au>Maruyama, Hirofumi</au><au>Matsumoto, Masayasu</au><aucorp>Department of Clinical Neuroscience and Therapeutics</aucorp><aucorp>Hiroshima University Graduate School of Biomedical Sciences</aucorp><aucorp>Hoshigaoka Medical Center</aucorp><aucorp>Japan Community Healthcare Organization (JCHO</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alpha-2-macroglobulin as a Promising Biological Marker of Endothelial Function</atitle><jtitle>Journal of Atherosclerosis and Thrombosis</jtitle><addtitle>JAT</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>25</volume><issue>4</issue><spage>350</spage><epage>358</epage><pages>350-358</pages><issn>1340-3478</issn><eissn>1880-3873</eissn><abstract>Aims: Alpha-2-macroglobulin (α2MG) is thought to be associated with inflammatory reactions and procoagulant properties that might cause ischemic stroke. Endothelial dysfunction plays an important role in atherosclerosis development and in the occurrence of cardiovascular events. In this study, we investigated whether serum α2MG levels, endothelial function, and endothelial progenitor cell (EPC) number were associated in patients with chronic stroke or cardiovascular risk factors.Methods: Patients with a history of stroke or any established cardiovascular risk factors were enrolled in this study (n=102; 69 men, 70.1±9.2 years). Endothelial function was assessed by flow-mediated dilation (FMD). EPC numbers (CD34＋/CD133＋) were measured using flow cytometry (n=91). Serum α2MG levels were measured by nephelometry.Results: Patients in the highest tertile of serum α2MG levels were older (P=0.019) and more frequently exhibited dyslipidemia (P=0.021). Univariate-regression analysis revealed that increased α2MG levels were negatively associated with FMD values (r=−0.25; P=0.010), whereas increased EPC numbers were positively associated (r=0.21; P=0.044). Multivariate-regression analysis adjusted for male gender, hypertension, and severe white-matter lesions showed that serum α2MG levels were independently associated with FMD values (standardized partial regression coefficient [β] −0.185; P=0.033), although not significantly associated with EPC numbers.Conclusion: Serum α2MG levels might reflect endothelial dysfunction evaluated by FMD in patients with chronic stroke or cardiovascular risk factors.</abstract><cop>Japan</cop><pub>Japan Atherosclerosis Society</pub><pmid>29093276</pmid><doi>10.5551/jat.41335</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Atherosclerosis - pathology Biological marker Biomarkers - blood Cardiovascular Diseases - blood Dyslipidemias - blood Endothelial dysfunction Endothelial progenitor cell Endothelial Progenitor Cells Endothelium, Vascular - pathology Female Flow Cytometry Flow-mediated dilation Glomerular Filtration Rate Humans Hypertension - blood Inflammation - pathology Magnetic Resonance Imaging Male Middle Aged Multivariate Analysis Original Pregnancy-Associated alpha 2-Macroglobulins - analysis Prospective Studies Regression Analysis Risk Factors Stem Cells - cytology Stroke Stroke - blood Stroke - pathology |
| title | Alpha-2-macroglobulin as a Promising Biological Marker of Endothelial Function |
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