Carbon Monoxide Inhibits Islet Apoptosis via Induction of Autophagy

Carbon monoxide (CO) functions as a therapeutic molecule in various disease models because of its anti-inflammatory and antiapoptotic properties. We investigated the capacity of CO to reduce hypoxia-induced islet cell death and dysfunction in human and mouse models. Culturing islets in CO-saturated...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Antioxidants & redox signaling 2018-05, Vol.28 (14), p.1309-1322
Hauptverfasser:	Kim, Do-Sung, Song, Lili, Wang, Jingjing, Wu, Hongju, Gou, Wenyu, Cui, Wanxing, Kim, Jae-Sung, Wang, Hongjun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Apoptosis Autophagy BIM protein Carbon monoxide Cell death Diabetes Diabetes mellitus Endoplasmic reticulum Exposure Grafting Grafts Hypoxia Inflammation Innovations Islet cells Mortality Original Research Communications Pancreatic islet transplantation Phagocytosis Poly(ADP-ribose) polymerase Pretreatment Proteins Rodents siRNA Streptozocin Survival Transplantation Tumor necrosis factor-α
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!