Large Cardiac Muscle Patches Engineered From Human Induced-Pluripotent Stem Cell–Derived Cardiac Cells Improve Recovery From Myocardial Infarction in Swine

BACKGROUND:Here, we generated human cardiac muscle patches (hCMPs) of clinically relevant dimensions (4 cm × 2 cm × 1.25 mm) by suspending cardiomyocytes, smooth muscle cells, and endothelial cells that had been differentiated from human induced-pluripotent stem cells in a fibrin scaffold and then c...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2018-04, Vol.137 (16), p.1712-1730
Hauptverfasser:	Gao, Ling, Gregorich, Zachery R, Zhu, Wuqiang, Mattapally, Saidulu, Oduk, Yasin, Lou, Xi, Kannappan, Ramaswamy, Borovjagin, Anton V, Walcott, Gregory P, Pollard, Andrew E, Fast, Vladimir G, Hu, Xinyang, Lloyd, Steven G, Ge, Ying, Zhang, Jianyi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation Cells, Cultured Disease Models, Animal Endothelial Cells - metabolism Endothelial Cells - pathology Endothelial Cells - transplantation Gene Expression Regulation Humans Induced Pluripotent Stem Cells - physiology Induced Pluripotent Stem Cells - transplantation Myocardial Infarction - genetics Myocardial Infarction - pathology Myocardial Infarction - physiopathology Myocardial Infarction - surgery Myocardium - pathology Myocytes, Cardiac - pathology Myocytes, Cardiac - transplantation Myocytes, Smooth Muscle - pathology Myocytes, Smooth Muscle - transplantation Recovery of Function Regeneration - genetics Stem Cell Transplantation - methods Sus scrofa Time Factors Tissue Engineering - methods Tissue Scaffolds Transplantation, Heterologous Ventricular Function, Left Ventricular Remodeling
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!