Discovery of a Novel Dibromoquinoline Compound Exhibiting Potent Antifungal and Antivirulence Activity That Targets Metal Ion Homeostasis

Globally, invasive fungal infections pose a significant challenge to modern human medicine due to the limited number of antifungal drugs and the rise in resistance to current antifungal agents. A vast majority of invasive fungal infections are caused by species of Candida, Cryptococcus, and Aspergil...

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Veröffentlicht in:	ACS infectious diseases 2018-03, Vol.4 (3), p.403-414
Hauptverfasser:	Mohammad, Haroon, Elghazawy, Nehal H, Eldesouky, Hassan E, Hegazy, Youssef A, Younis, Waleed, Avrimova, Larisa, Hazbun, Tony, Arafa, Reem K, Seleem, Mohamed N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antifungal Agents - chemical synthesis Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Antifungal Agents - therapeutic use Aspergillus - drug effects Aspergillus - metabolism Caenorhabditis elegans - microbiology Caenorhabditis elegans - physiology Candida - drug effects Candida - metabolism Cryptococcus - drug effects Cryptococcus - metabolism Culture Media - chemistry Disease Models, Animal Homeostasis - drug effects Ions - metabolism Metals - metabolism Mycoses - drug therapy Quinolines - chemical synthesis Quinolines - isolation & purification Quinolines - pharmacology Quinolines - therapeutic use Survival Analysis
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