Angiogenic factor imbalance precedes complement deposition in placentae of the BPH/5 model of preeclampsia

Preeclampsia (PE), a hypertensive disorder of pregnancy, is a leading cause of maternal and fetal morbidity and mortality. Although the etiology is unknown, PE is thought to be caused by defective implantation and decidualization in pregnancy. Pregnant blood pressure high (BPH)/5 mice spontaneously...

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Veröffentlicht in:	The FASEB journal 2018-05, Vol.32 (5), p.2574-2586
Hauptverfasser:	Sones, Jennifer L., Merriam, Audrey A., Seffens, Angelina, Brown‐Grant, Dex‐Ann, Butler, Scott D., Zhao, Anna M., Xu, Xinjing, Shawber, Carrie J., Grenier, Jennifer K., Douglas, Nataki C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Complement System Proteins - genetics Complement System Proteins - metabolism Decidua - blood supply Decidua - metabolism Decidua - pathology decidual vasculature Disease Models, Animal Female Gene Expression Regulation Humans implantation Mice Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Pre-Eclampsia - genetics Pre-Eclampsia - metabolism Pre-Eclampsia - pathology Pregnancy RGC32 sFlt‐1 trophoblast Trophoblasts - metabolism Trophoblasts - pathology Vascular Endothelial Growth Factor A - biosynthesis Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor Receptor-1 - biosynthesis Vascular Endothelial Growth Factor Receptor-1 - genetics VEGF
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