E4BP4/NFIL3 modulates the epigenetically repressed RAS effector RASSF8 function through histone methyltransferases

RAS proteins are major human oncogenes, and most of the studies are focused on enzymatic RAS effectors. Recently, nonenzymatic RAS effectors (RASSF, RAS association domain family) have garnered special attention because of their tumor-suppressive properties in contrast to the oncogenic potential of...

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Veröffentlicht in:	The Journal of biological chemistry 2018-04, Vol.293 (15), p.5624-5635
Hauptverfasser:	Karthik, Isai Pratha, Desai, Pavitra, Sukumar, Sudarkodi, Dimitrijevic, Aleksandra, Rajalingam, Krishnaraj, Mahalingam, Sundarasamy
Format:	Artikel
Sprache:	eng
Schlagworte:	apoptosis Basic-Leucine Zipper Transcription Factors - genetics Basic-Leucine Zipper Transcription Factors - metabolism breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism cell proliferation E4BP4 Epigenesis, Genetic Female G9a Gene Expression Regulation, Neoplastic HEK293 Cells Histocompatibility Antigens - genetics Histocompatibility Antigens - metabolism histone methylation Histone-Lysine N-Methyltransferase - genetics Histone-Lysine N-Methyltransferase - metabolism Humans MCF-7 Cells Methyltransferases - genetics Methyltransferases - metabolism Molecular Bases of Disease Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Ras protein RASSF8 Repressor Proteins - genetics Repressor Proteins - metabolism SUV39H1 tumor cell biology tumor suppressor gene Tumor Suppressor Proteins - biosynthesis Tumor Suppressor Proteins - genetics
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