Evolution of an allosteric “off switch” in apoptotic caspases

Caspase-3 is well known as the “executioner” whose activation commits the cell to an apoptotic fate, but low levels of caspase-3 activity also play key roles in development. A new study explains how cells can balance these functions, using biophysical, structural, and computational approaches to dem...

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Veröffentlicht in:	The Journal of biological chemistry 2018-04, Vol.293 (15), p.5462-5463
1. Verfasser:	Herr, Andrew B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation Animals apoptosis caspase Caspase 3 - chemistry Caspase 3 - genetics Caspase 3 - metabolism Catalysis Editors' Picks Highlights Humans Phosphorylation protein evolution Protein Structure, Secondary Structure-Activity Relationship
Online-Zugang:	Volltext
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