Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants contributing to lipid levels and coronary artery disease

Most genome-wide association studies have been conducted in European individuals, even though most genetic variation in humans is seen only in non-European samples. To search for novel loci associated with blood lipid levels and clarify the mechanism of action at previously identified lipid loci, we...

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Veröffentlicht in:	Nature genetics 2017-10, Vol.49 (12), p.1722-1730
Hauptverfasser:	Lu, Xiangfeng, Peloso, Gina M, Liu, Dajiang J., Wu, Ying, Zhang, He, Zhou, Wei, Li, Jun, Tang, Clara Sze-man, Dorajoo, Rajkumar, Li, Huaixing, Long, Jirong, Guo, Xiuqing, Xu, Ming, Spracklen, Cassandra N., Chen, Yang, Liu, Xuezhen, Zhang, Yan, Khor, Chiea Chuen, Liu, Jianjun, Sun, Liang, Wang, Laiyuan, Gao, Yu-Tang, Hu, Yao, Yu, Kuai, Wang, Yiqin, Cheung, Chloe Yu Yan, Wang, Feijie, Huang, Jianfeng, Fan, Qiao, Cai, Qiuyin, Chen, Shufeng, Shi, Jinxiu, Yang, Xueli, Zhao, Wanting, Sheu, Wayne H.-H., Cherny, Stacey Shawn, He, Meian, Feranil, Alan B., Adair, Linda S., Gordon-Larsen, Penny, Du, Shufa, Varma, Rohit, da Chen, Yii-Der I, Shu, XiaoOu, Lam, Karen Siu Ling, Wong, Tien Yin, Ganesh, Santhi K., Mo, Zengnan, Hveem, Kristian, Fritsche, Lars, Nielsen, Jonas Bille, Tse, Hung-fat, Huo, Yong, Cheng, Ching-Yu, Chen, Y. Eugene, Zheng, Wei, Tai, E Shyong, Gao, Wei, Lin, Xu, Huang, Wei, Abecasis, Goncalo, Consortium, GLGC, Kathiresan, Sekar, Mohlke, Karen L., Wu, Tangchun, Sham, Pak Chung, Gu, Dongfeng, Willer, Cristen J
Format:	Artikel
Sprache:	eng
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