Glucuronylated core 1 glycans are required for precise localization of neuromuscular junctions and normal formation of basement membranes on Drosophila muscles

T antigen (Galβ1-3GalNAcα1-Ser/Thr) is an evolutionary-conserved mucin-type core 1 glycan structure in animals synthesized by core 1 β1,3-galactosyltransferase 1 (C1GalT1). Previous studies showed that T antigen produced by Drosophila C1GalT1 (dC1GalT1) was expressed in various tissues and dC1GalT1...

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Veröffentlicht in:	Developmental biology 2018-04, Vol.436 (2), p.108-124
Hauptverfasser:	Itoh, Kazuyoshi, Akimoto, Yoshihiro, Kondo, Shu, Ichimiya, Tomomi, Aoki, Kazuhiro, Tiemeyer, Michael, Nishihara, Shoko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Tumor-Associated, Carbohydrate - metabolism Basement membrane Basement Membrane - metabolism Blotting, Western Drosophila - genetics Drosophila Proteins - metabolism Drosophila β1,3-glucuronyltransferase-P Glucuronosyltransferase - metabolism Glucuronylated core 1 glycan Immunoblotting Larva - metabolism Mass Spectrometry Mucin-type O-glycan Muscles - metabolism Neuromuscular junction Neuromuscular Junction - metabolism Phenotype Polysaccharides - metabolism Real-Time Polymerase Chain Reaction
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