The importance of membrane microdomains for bile salt-dependent biliary lipid secretion

Alternative models explaining the biliary lipid secretion at the canalicular membrane of hepatocytes exist: successive lipid extraction by preformed bile salt micelles, or budding of membrane fragments with formation of mixed micelles. To test the feasibility of the latter mechanism, we developed a...

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Veröffentlicht in:	Journal of cell science 2018-03, Vol.131 (5), p.jcs211524-jcs211524
Hauptverfasser:	Eckstein, Johannes, Holzhütter, Hermann-Georg, Berndt, Nikolaus
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP Binding Cassette Transporter, Subfamily B - genetics ATP Binding Cassette Transporter, Subfamily B - metabolism ATP Binding Cassette Transporter, Subfamily G, Member 5 - genetics ATP Binding Cassette Transporter, Subfamily G, Member 8 - genetics ATP-Binding Cassette Sub-Family B Member 4 Bile Bile Acids and Salts - metabolism Bile Canaliculi - growth & development Bile Canaliculi - metabolism Biliary Tract - growth & development Biliary Tract - metabolism Cholesterol Cholesterol - metabolism Computer simulation Feasibility studies Hepatocytes Hepatocytes - metabolism Lecithin Lipids Lipids - biosynthesis Lipids - genetics Liver Mathematical analysis Mathematical models Membrane Lipids - genetics Membrane Lipids - metabolism Membrane proteins Mice Micelles Models, Theoretical Monomers Phosphatidylcholine Phosphatidylcholines - genetics Phosphatidylcholines - metabolism Salts Secretion
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