The NLRC4 Inflammasome

Summary 15 years ago, the fundamental biology of an inflammatory signaling complex eventually dubbed “the inflammasome” began to unravel in chronologic parallel with the discovery that many inflammatory diseases were associated with its hyperactivity. Though the genetic origins of Familial Mediterra...

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Veröffentlicht in:	Immunological reviews 2018-01, Vol.281 (1), p.115-123
Hauptverfasser:	Duncan, Joseph A., Canna, Scott W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animals Autoimmune Diseases - genetics Autoimmune Diseases - metabolism Autoinflammation Biology Calcium-Binding Proteins - metabolism CARD Signaling Adaptor Proteins - metabolism Diseases Familial Mediterranean fever Familial Mediterranean Fever - genetics Fever Flagellin Humans Hyperactivity Infections - metabolism Inflammasome Inflammasomes Inflammasomes - metabolism Inflammation Inflammation - metabolism Inflammatory diseases interleukin‐18 Mutation Pyrin - genetics Pyrin - metabolism Pyrin protein Signal Transduction Signaling Structure-function relationships
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