Translational profiling of retinal ganglion cell optic nerve regeneration in Xenopus laevis

Unlike adult mammals, adult frogs regrow their optic nerve following a crush injury, making Xenopus laevis a compelling model for studying the molecular mechanisms that underlie neuronal regeneration. Using Translational Ribosome Affinity Purification (TRAP), a method to isolate ribosome-associated...

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Veröffentlicht in:	Developmental biology 2017-06, Vol.426 (2), p.360-373
Hauptverfasser:	Whitworth, G.B., Misaghi, B.C., Rosenthal, D.M., Mills, E.A., Heinen, D.J., Watson, A.H., Ives, C.W., Ali, S.H., Bezold, K., Marsh-Armstrong, N., Watson, F.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Animals, Genetically Modified Expression profile Eye Proteins - biosynthesis Eye Proteins - genetics Gene Expression Regulation Gene Ontology Molecular Sequence Annotation Nerve Crush Nerve Regeneration - physiology Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - genetics Optic nerve crush injury Optic Nerve Injuries - physiopathology Retinal Ganglion Cells - metabolism Ribosomes - metabolism RNA, Messenger - genetics RNA, Messenger - isolation & purification Sequence Alignment Sequence Analysis, RNA Sequence Homology, Amino Acid Signal Transduction TRAP Xenopus laevis - genetics Xenopus laevis - physiology Xenopus Proteins - biosynthesis Xenopus Proteins - genetics
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