[18F]AV‐1451 tau‐PET and primary progressive aphasia

Objectives To assess [18F]AV‐1451 tau‐PET (positron emission tomography) uptake patterns across the primary progressive aphasia (PPA) variants (logopenic, semantic, and agrammatic), examine regional uptake patterns of [18F]AV‐1451 independent of clinical diagnosis, and compare the diagnostic utility...

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Veröffentlicht in:	Annals of neurology 2018-03, Vol.83 (3), p.599-611
Hauptverfasser:	Josephs, Keith A., Martin, Peter R., Botha, Hugo, Schwarz, Christopher G., Duffy, Joseph R., Clark, Heather M., Machulda, Mary M., Graff‐Radford, Jonathan, Weigand, Stephen D., Senjem, Matthew L., Utianski, Rene L., Drubach, Daniel A., Boeve, Bradley F., Jones, David T., Knopman, David S., Petersen, Ronald C., Jack, Clifford R., Lowe, Val J., Whitwell, Jennifer L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aphasia Aphasia - diagnosis Aphasia - pathology Aphasia, Primary Progressive - diagnosis Aphasia, Primary Progressive - pathology Brain Brain - pathology Carbolines - pharmacology Cognition - physiology Diagnosis Diagnostic systems Emission analysis Female Fluorine isotopes Humans Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Medical imaging Middle Aged Neocortex Neuroimaging Neuropsychological Tests NMR Nuclear magnetic resonance Positron emission Positron emission tomography Positron-Emission Tomography - methods Principal components analysis Regional analysis Regression analysis Semantics Speech disorders Statistical analysis Statistical methods Substantia alba Substantia grisea Tau protein Tomography White Matter - pathology
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