Triple Negative Breast Cancer Depends on Sphingosine Kinase 1 (SphK1)/Sphingosine-1-Phosphate (S1P)/Sphingosine 1-Phosphate Receptor 3 (S1PR3)/Notch Signaling for Metastasis

BACKGROUND Triple negative breast cancer (TNBC) has a more aggressive recurrence. Previous reports have demonstrated that sphingosine kinase 1 (SphK1) is a crucial regulator of breast cancer progression. However, the correlation of SphK1 with clinical prognosis has been poorly investigated. Thus, we...

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Veröffentlicht in:	Medical science monitor 2018-04, Vol.24, p.1912-1923
Hauptverfasser:	Wang, Shushu, Liang, Yueyang, Chang, Wenxiao, Hu, Baoquan, Zhang, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Doxorubicin - pharmacology Drug Synergism Female Fluorouracil - pharmacology Heterografts Humans Lab/In Vitro Research Lysophospholipids - metabolism MCF-7 Cells Mice Mice, Inbred NOD Mice, SCID Middle Aged Neoplasm Metastasis Neoplasm Recurrence, Local - enzymology Neoplasm Recurrence, Local - metabolism Neoplasm Recurrence, Local - pathology Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors Phosphotransferases (Alcohol Group Acceptor) - biosynthesis Phosphotransferases (Alcohol Group Acceptor) - metabolism Pyrrolidines - pharmacology Receptor, ErbB-2 - biosynthesis Receptor, ErbB-2 - genetics Receptors, Lysosphingolipid - metabolism Receptors, Notch - metabolism Signal Transduction Sphingosine - analogs & derivatives Sphingosine - metabolism Sulfones - pharmacology Triple Negative Breast Neoplasms - drug therapy Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - metabolism Triple Negative Breast Neoplasms - pathology Up-Regulation
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