Urinary Urea, Uric Acid and Hippuric Acid as Potential Biomarkers in Multiple Sclerosis Patients
Urine is a proven source of metabolite biomarkers and has the potential to be a rapid, noninvasive, inexpensive, and efficient diagnostic tool for various human diseases. Despite these advantages, urine is an under-investigated source of biomarkers for multiple sclerosis (MS). The objective was to i...
Gespeichert in:
| Veröffentlicht in: | Indian journal of clinical biochemistry 2018-04, Vol.33 (2), p.163-170 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 170 |
|---|---|
| container_issue | 2 |
| container_start_page | 163 |
| container_title | Indian journal of clinical biochemistry |
| container_volume | 33 |
| creator | Atya, Hanaa B. Ali, Sahar A. Hegazy, Mohamed I. El Sharkawi, Fathia Z. |
| description | Urine is a proven source of metabolite biomarkers and has the potential to be a rapid, noninvasive, inexpensive, and efficient diagnostic tool for various human diseases. Despite these advantages, urine is an under-investigated source of biomarkers for multiple sclerosis (MS). The objective was to investigate the level of some urinary metabolites (urea, uric acid and hippuric acid) in patients with MS and correlate their levels to the severity of the disease, MS subtypes and MS treatment. The urine samples were collected from 73 MS patients-48 with RRMS and 25 with SPMS- and age matched 75 healthy controls. The values of urinary urea, uric acid and hippuric acid in MS patients were significantly decreased, and these metabolites in SPMS pattern showed significantly decrease than RRMS pattern. Also showed significant inverse correlation with expanded disability status scale and number of relapses. Accordingly, they may act as a potential urinary biomarkers for MS, and correlate to disease progression. |
| doi_str_mv | 10.1007/s12291-017-0661-6 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5891453</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A714404466</galeid><sourcerecordid>A714404466</sourcerecordid><originalsourceid>FETCH-LOGICAL-c637t-318b8052637538c635a1048a9e4a047ce35f2fa4281dda8d5d53da77d533326d3</originalsourceid><addsrcrecordid>eNp1kl1rFDEUhoMotq7-AG9kwBsFp-Y7MzeFtagtVBTrXsc0yayps8mYzIj9955x69YVJZCPk-e8Jx8vQo8JPiIYq5eFUNqSGhNVYylJLe-gQ9wqXmNO6d1fc1yTlogD9KCUK4wZx5zcRwe0lYJQLA_R51UO0eTrapW9eQF9sNXSBleZ6KrTMAzTbaRUH9Lo4xhMX70KaWPyV59LFWL1burHMPS-urC9z6kEQM0YgC0P0b3O9MU_uhkXaPXm9aeT0_r8_duzk-V5bSVTY81Ic9lgQWEhWAMxYQjmjWk9N5gr65noaGc4bYhzpnHCCeaMUjAwRqVjC3S81R2my413Fmpn0-shBzjntU4m6P2dGL7odfquRdMSDioL9OxGIKdvky-j3oRifd-b6NNUNMVUMEIVU4A-_Qu9SlOOcL2ZgvMwAYo7am16r0PsEtS1s6heKsLhK7iUQB39g4Lm_CbYFH0XIL6X8HwvAZjR_xjXZipFn1183GfJlrXwKSX7bvceBOvZQnprIQ0W0rOF9Jzz5M-H3GX89gwAdAsU2Iprn29v_3_Vn8ECzd0</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2023323545</pqid></control><display><type>article</type><title>Urinary Urea, Uric Acid and Hippuric Acid as Potential Biomarkers in Multiple Sclerosis Patients</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>SpringerNature Journals</source><source>PubMed Central</source><creator>Atya, Hanaa B. ; Ali, Sahar A. ; Hegazy, Mohamed I. ; El Sharkawi, Fathia Z.</creator><creatorcontrib>Atya, Hanaa B. ; Ali, Sahar A. ; Hegazy, Mohamed I. ; El Sharkawi, Fathia Z.</creatorcontrib><description>Urine is a proven source of metabolite biomarkers and has the potential to be a rapid, noninvasive, inexpensive, and efficient diagnostic tool for various human diseases. Despite these advantages, urine is an under-investigated source of biomarkers for multiple sclerosis (MS). The objective was to investigate the level of some urinary metabolites (urea, uric acid and hippuric acid) in patients with MS and correlate their levels to the severity of the disease, MS subtypes and MS treatment. The urine samples were collected from 73 MS patients-48 with RRMS and 25 with SPMS- and age matched 75 healthy controls. The values of urinary urea, uric acid and hippuric acid in MS patients were significantly decreased, and these metabolites in SPMS pattern showed significantly decrease than RRMS pattern. Also showed significant inverse correlation with expanded disability status scale and number of relapses. Accordingly, they may act as a potential urinary biomarkers for MS, and correlate to disease progression.</description><identifier>ISSN: 0970-1915</identifier><identifier>EISSN: 0974-0422</identifier><identifier>DOI: 10.1007/s12291-017-0661-6</identifier><identifier>PMID: 29651206</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Biochemistry ; Biological markers ; Biomarkers ; Biomedical and Life Sciences ; Care and treatment ; Chemistry/Food Science ; Development and progression ; Life Sciences ; Metabolites ; Microbiology ; Multiple sclerosis ; Original ; Original Article ; Pathology ; Patients ; Urea ; Uric acid ; Urine</subject><ispartof>Indian journal of clinical biochemistry, 2018-04, Vol.33 (2), p.163-170</ispartof><rights>Association of Clinical Biochemists of India 2017</rights><rights>COPYRIGHT 2018 Springer</rights><rights>Indian Journal of Clinical Biochemistry is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c637t-318b8052637538c635a1048a9e4a047ce35f2fa4281dda8d5d53da77d533326d3</citedby><cites>FETCH-LOGICAL-c637t-318b8052637538c635a1048a9e4a047ce35f2fa4281dda8d5d53da77d533326d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891453/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891453/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,41488,42557,51319,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29651206$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Atya, Hanaa B.</creatorcontrib><creatorcontrib>Ali, Sahar A.</creatorcontrib><creatorcontrib>Hegazy, Mohamed I.</creatorcontrib><creatorcontrib>El Sharkawi, Fathia Z.</creatorcontrib><title>Urinary Urea, Uric Acid and Hippuric Acid as Potential Biomarkers in Multiple Sclerosis Patients</title><title>Indian journal of clinical biochemistry</title><addtitle>Ind J Clin Biochem</addtitle><addtitle>Indian J Clin Biochem</addtitle><description>Urine is a proven source of metabolite biomarkers and has the potential to be a rapid, noninvasive, inexpensive, and efficient diagnostic tool for various human diseases. Despite these advantages, urine is an under-investigated source of biomarkers for multiple sclerosis (MS). The objective was to investigate the level of some urinary metabolites (urea, uric acid and hippuric acid) in patients with MS and correlate their levels to the severity of the disease, MS subtypes and MS treatment. The urine samples were collected from 73 MS patients-48 with RRMS and 25 with SPMS- and age matched 75 healthy controls. The values of urinary urea, uric acid and hippuric acid in MS patients were significantly decreased, and these metabolites in SPMS pattern showed significantly decrease than RRMS pattern. Also showed significant inverse correlation with expanded disability status scale and number of relapses. Accordingly, they may act as a potential urinary biomarkers for MS, and correlate to disease progression.</description><subject>Biochemistry</subject><subject>Biological markers</subject><subject>Biomarkers</subject><subject>Biomedical and Life Sciences</subject><subject>Care and treatment</subject><subject>Chemistry/Food Science</subject><subject>Development and progression</subject><subject>Life Sciences</subject><subject>Metabolites</subject><subject>Microbiology</subject><subject>Multiple sclerosis</subject><subject>Original</subject><subject>Original Article</subject><subject>Pathology</subject><subject>Patients</subject><subject>Urea</subject><subject>Uric acid</subject><subject>Urine</subject><issn>0970-1915</issn><issn>0974-0422</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kl1rFDEUhoMotq7-AG9kwBsFp-Y7MzeFtagtVBTrXsc0yayps8mYzIj9955x69YVJZCPk-e8Jx8vQo8JPiIYq5eFUNqSGhNVYylJLe-gQ9wqXmNO6d1fc1yTlogD9KCUK4wZx5zcRwe0lYJQLA_R51UO0eTrapW9eQF9sNXSBleZ6KrTMAzTbaRUH9Lo4xhMX70KaWPyV59LFWL1burHMPS-urC9z6kEQM0YgC0P0b3O9MU_uhkXaPXm9aeT0_r8_duzk-V5bSVTY81Ic9lgQWEhWAMxYQjmjWk9N5gr65noaGc4bYhzpnHCCeaMUjAwRqVjC3S81R2my413Fmpn0-shBzjntU4m6P2dGL7odfquRdMSDioL9OxGIKdvky-j3oRifd-b6NNUNMVUMEIVU4A-_Qu9SlOOcL2ZgvMwAYo7am16r0PsEtS1s6heKsLhK7iUQB39g4Lm_CbYFH0XIL6X8HwvAZjR_xjXZipFn1183GfJlrXwKSX7bvceBOvZQnprIQ0W0rOF9Jzz5M-H3GX89gwAdAsU2Iprn29v_3_Vn8ECzd0</recordid><startdate>20180401</startdate><enddate>20180401</enddate><creator>Atya, Hanaa B.</creator><creator>Ali, Sahar A.</creator><creator>Hegazy, Mohamed I.</creator><creator>El Sharkawi, Fathia Z.</creator><general>Springer India</general><general>Springer</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>04Q</scope><scope>04W</scope><scope>3V.</scope><scope>7XB</scope><scope>88A</scope><scope>88I</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180401</creationdate><title>Urinary Urea, Uric Acid and Hippuric Acid as Potential Biomarkers in Multiple Sclerosis Patients</title><author>Atya, Hanaa B. ; Ali, Sahar A. ; Hegazy, Mohamed I. ; El Sharkawi, Fathia Z.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c637t-318b8052637538c635a1048a9e4a047ce35f2fa4281dda8d5d53da77d533326d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Biochemistry</topic><topic>Biological markers</topic><topic>Biomarkers</topic><topic>Biomedical and Life Sciences</topic><topic>Care and treatment</topic><topic>Chemistry/Food Science</topic><topic>Development and progression</topic><topic>Life Sciences</topic><topic>Metabolites</topic><topic>Microbiology</topic><topic>Multiple sclerosis</topic><topic>Original</topic><topic>Original Article</topic><topic>Pathology</topic><topic>Patients</topic><topic>Urea</topic><topic>Uric acid</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Atya, Hanaa B.</creatorcontrib><creatorcontrib>Ali, Sahar A.</creatorcontrib><creatorcontrib>Hegazy, Mohamed I.</creatorcontrib><creatorcontrib>El Sharkawi, Fathia Z.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>India Database</collection><collection>India Database: Science & Technology</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Indian journal of clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Atya, Hanaa B.</au><au>Ali, Sahar A.</au><au>Hegazy, Mohamed I.</au><au>El Sharkawi, Fathia Z.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urinary Urea, Uric Acid and Hippuric Acid as Potential Biomarkers in Multiple Sclerosis Patients</atitle><jtitle>Indian journal of clinical biochemistry</jtitle><stitle>Ind J Clin Biochem</stitle><addtitle>Indian J Clin Biochem</addtitle><date>2018-04-01</date><risdate>2018</risdate><volume>33</volume><issue>2</issue><spage>163</spage><epage>170</epage><pages>163-170</pages><issn>0970-1915</issn><eissn>0974-0422</eissn><abstract>Urine is a proven source of metabolite biomarkers and has the potential to be a rapid, noninvasive, inexpensive, and efficient diagnostic tool for various human diseases. Despite these advantages, urine is an under-investigated source of biomarkers for multiple sclerosis (MS). The objective was to investigate the level of some urinary metabolites (urea, uric acid and hippuric acid) in patients with MS and correlate their levels to the severity of the disease, MS subtypes and MS treatment. The urine samples were collected from 73 MS patients-48 with RRMS and 25 with SPMS- and age matched 75 healthy controls. The values of urinary urea, uric acid and hippuric acid in MS patients were significantly decreased, and these metabolites in SPMS pattern showed significantly decrease than RRMS pattern. Also showed significant inverse correlation with expanded disability status scale and number of relapses. Accordingly, they may act as a potential urinary biomarkers for MS, and correlate to disease progression.</abstract><cop>New Delhi</cop><pub>Springer India</pub><pmid>29651206</pmid><doi>10.1007/s12291-017-0661-6</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0970-1915 |
| ispartof | Indian journal of clinical biochemistry, 2018-04, Vol.33 (2), p.163-170 |
| issn | 0970-1915 0974-0422 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5891453 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SpringerNature Journals; PubMed Central |
| subjects | Biochemistry Biological markers Biomarkers Biomedical and Life Sciences Care and treatment Chemistry/Food Science Development and progression Life Sciences Metabolites Microbiology Multiple sclerosis Original Original Article Pathology Patients Urea Uric acid Urine |
| title | Urinary Urea, Uric Acid and Hippuric Acid as Potential Biomarkers in Multiple Sclerosis Patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-21T05%3A55%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Urinary%20Urea,%20Uric%20Acid%20and%20Hippuric%20Acid%20as%20Potential%20Biomarkers%20in%20Multiple%20Sclerosis%20Patients&rft.jtitle=Indian%20journal%20of%20clinical%20biochemistry&rft.au=Atya,%20Hanaa%20B.&rft.date=2018-04-01&rft.volume=33&rft.issue=2&rft.spage=163&rft.epage=170&rft.pages=163-170&rft.issn=0970-1915&rft.eissn=0974-0422&rft_id=info:doi/10.1007/s12291-017-0661-6&rft_dat=%3Cgale_pubme%3EA714404466%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2023323545&rft_id=info:pmid/29651206&rft_galeid=A714404466&rfr_iscdi=true |