The deubiquitinating enzyme USP20 stabilizes ULK1 and promotes autophagy initiation

Autophagy begins with the formation of autophagosomes, a process that depends on the activity of the serine/threonine kinase ULK1 (hATG1). Although earlier studies indicated that ULK1 activity is regulated by dynamic polyubiquitination, the deubiquitinase involved in the regulation of ULK1 remained...

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Veröffentlicht in:	EMBO reports 2018-04, Vol.19 (4), p.n/a
Hauptverfasser:	Kim, Jun Hwan, Seo, Dongyeob, Kim, Sun‐Jick, Choi, Dong Wook, Park, Jin Seok, Ha, Jihoon, Choi, Jungwon, Lee, Ji‐Hyung, Jung, Su Myung, Seo, Kyoung‐Wan, Lee, Eun‐Woo, Lee, Youn Sook, Cheong, Heesun, Choi, Cheol Yong, Park, Seok Hee
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Autophagy Autophagy - genetics Autophagy-Related Protein-1 Homolog - genetics Autophagy-Related Protein-1 Homolog - metabolism Cell Line Cell Survival Degradation Depletion deubiquitinase EMBO07 EMBO31 Enzymes Gene Expression HEK293 Cells Humans Kinases lysosomal degradation Lysosomes Lysosomes - metabolism Mice Phagocytosis Phagosomes Protein Binding Protein Stability Protein-serine/threonine kinase Proteolysis Ribonucleic acid RNA RNA Interference RNA, Small Interfering - genetics RNA-mediated interference Ubiquitin Ubiquitin Thiolesterase - genetics Ubiquitin Thiolesterase - metabolism Ubiquitination ULK1 USP20
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