Downregulation of leucine‐rich repeats and immunoglobulin‐like domains 1 by microRNA‐20a modulates gastric cancer multidrug resistance

Multidrug resistance (MDR) significantly restricts the clinical efficacy of gastric cancer (GC) chemotherapy, and it is critical to search novel targets to predict and overcome MDR. Leucine‐rich repeats and immunoglobulin‐like domains 1 (LRIG1) has been proved to be correlated with drug resistance i...

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Veröffentlicht in:	Cancer science 2018-04, Vol.109 (4), p.1044-1054
Hauptverfasser:	Zhou, Lin, Li, Xiaowei, Zhou, Fan, Jin, Zhi'an, Chen, Di, Wang, Pin, Zhang, Shu, Zhuge, Yuzheng, Shang, Yulong, Zou, Xiaoping
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics Cell Line, Tumor Cell Proliferation - genetics Down-Regulation - genetics Drug Resistance, Multiple - genetics Drug Resistance, Neoplasm - genetics epidermal growth factor receptor ErbB Receptors - genetics gastric cancer Gene Expression Regulation, Neoplastic - genetics Humans Leucine - genetics leucine‐rich repeats and immunoglobulin‐like domains 1 Membrane Glycoproteins - genetics MicroRNAs - genetics miR‐20a multidrug resistance Original Phosphatidylinositol 3-Kinases Stomach Neoplasms - genetics
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