Effect of phentermine on weight reduction in a pediatric weight management clinic
Phentermine is the most widely prescribed obesity medication in adults, yet studies of its use in the pediatric population are limited. We conducted a retrospective chart review of adolescents with obesity treated in a pediatric weight management clinic to examine the weight loss effectiveness of ph...
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| Veröffentlicht in: | International Journal of Obesity 2017-01, Vol.41 (1), p.90-93 |
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| creator | Ryder, J R Kaizer, A Rudser, K D Gross, A Kelly, A S Fox, C K |
| description | Phentermine is the most widely prescribed obesity medication in adults, yet studies of its use in the pediatric population are limited. We conducted a retrospective chart review of adolescents with obesity treated in a pediatric weight management clinic to examine the weight loss effectiveness of phentermine added to standard of care (SOC) lifestyle modification therapy versus SOC alone. All patients receiving phentermine plus SOC (
n
=25) were matched with a comparison group receiving only SOC (
n
=274). Differences at 1, 3 and 6 months were evaluated using generalized estimated equations adjusting for age, sex and baseline body mass index (BMI) and robust variance standard error estimates for confidence intervals and
P
-values. Phentermine use was associated with a greater percent change in BMI at 1 month (−1.6%; 95% confidence interval (CI): −2.6, −0.6%;
P
=0.001), 3 months (−2.9%; 95% CI: −4.5, −1.4%;
P |
| doi_str_mv | 10.1038/ijo.2016.185 |
| format | Article |
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n
=25) were matched with a comparison group receiving only SOC (
n
=274). Differences at 1, 3 and 6 months were evaluated using generalized estimated equations adjusting for age, sex and baseline body mass index (BMI) and robust variance standard error estimates for confidence intervals and
P
-values. Phentermine use was associated with a greater percent change in BMI at 1 month (−1.6%; 95% confidence interval (CI): −2.6, −0.6%;
P
=0.001), 3 months (−2.9%; 95% CI: −4.5, −1.4%;
P
<0.001) and 6 months (−4.1%; 95% CI: −7.1, −1.0%;
P
=0.009) compared with SOC alone, with no differences in systolic or diastolic blood pressure between groups. Heart rate was higher at all time-points in the phentermine plus SOC compared with SOC-only group. These data suggest that short-term use of phentermine added to SOC may enhance weight loss in adolescents with obesity in the clinical setting.</description><identifier>ISSN: 0307-0565</identifier><identifier>ISSN: 1476-5497</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/ijo.2016.185</identifier><identifier>PMID: 27773937</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/92/436/108 ; 692/308/575 ; 692/699/2743/393 ; 692/700/1720/3187 ; 692/700/2817 ; Adolescent ; Adolescent obesity ; Adolescents ; Anti-Obesity Agents - therapeutic use ; Behavior Therapy ; Blood pressure ; Body mass index ; Diet, Reducing ; Drug therapy ; Epidemiology ; FDA approval ; Female ; Gastrointestinal surgery ; Health Promotion and Disease Prevention ; Heart rate ; Humans ; Internal Medicine ; Lifestyles ; Male ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Minnesota - epidemiology ; Obesity ; Patient outcomes ; Pediatric Obesity - prevention & control ; Pediatric Obesity - therapy ; Pediatrics ; Phentermine ; Phentermine - therapeutic use ; Public Health ; Retrospective Studies ; Risk Reduction Behavior ; short-communication ; Teenagers ; Treatment Outcome ; Weight control ; Weight Loss - drug effects</subject><ispartof>International Journal of Obesity, 2017-01, Vol.41 (1), p.90-93</ispartof><rights>Macmillan Publishers Limited, part of Springer Nature. 2017</rights><rights>COPYRIGHT 2017 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jan 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c581t-b39b48c434d7fabce2fdfa566cedd7b57d92ace2277ae5c709f63e57e135dd233</citedby><cites>FETCH-LOGICAL-c581t-b39b48c434d7fabce2fdfa566cedd7b57d92ace2277ae5c709f63e57e135dd233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ijo.2016.185$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ijo.2016.185$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27773937$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ryder, J R</creatorcontrib><creatorcontrib>Kaizer, A</creatorcontrib><creatorcontrib>Rudser, K D</creatorcontrib><creatorcontrib>Gross, A</creatorcontrib><creatorcontrib>Kelly, A S</creatorcontrib><creatorcontrib>Fox, C K</creatorcontrib><title>Effect of phentermine on weight reduction in a pediatric weight management clinic</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes (Lond)</addtitle><description>Phentermine is the most widely prescribed obesity medication in adults, yet studies of its use in the pediatric population are limited. We conducted a retrospective chart review of adolescents with obesity treated in a pediatric weight management clinic to examine the weight loss effectiveness of phentermine added to standard of care (SOC) lifestyle modification therapy versus SOC alone. All patients receiving phentermine plus SOC (
n
=25) were matched with a comparison group receiving only SOC (
n
=274). Differences at 1, 3 and 6 months were evaluated using generalized estimated equations adjusting for age, sex and baseline body mass index (BMI) and robust variance standard error estimates for confidence intervals and
P
-values. Phentermine use was associated with a greater percent change in BMI at 1 month (−1.6%; 95% confidence interval (CI): −2.6, −0.6%;
P
=0.001), 3 months (−2.9%; 95% CI: −4.5, −1.4%;
P
<0.001) and 6 months (−4.1%; 95% CI: −7.1, −1.0%;
P
=0.009) compared with SOC alone, with no differences in systolic or diastolic blood pressure between groups. Heart rate was higher at all time-points in the phentermine plus SOC compared with SOC-only group. These data suggest that short-term use of phentermine added to SOC may enhance weight loss in adolescents with obesity in the clinical setting.</description><subject>631/92/436/108</subject><subject>692/308/575</subject><subject>692/699/2743/393</subject><subject>692/700/1720/3187</subject><subject>692/700/2817</subject><subject>Adolescent</subject><subject>Adolescent obesity</subject><subject>Adolescents</subject><subject>Anti-Obesity Agents - therapeutic use</subject><subject>Behavior Therapy</subject><subject>Blood pressure</subject><subject>Body mass index</subject><subject>Diet, Reducing</subject><subject>Drug therapy</subject><subject>Epidemiology</subject><subject>FDA approval</subject><subject>Female</subject><subject>Gastrointestinal surgery</subject><subject>Health Promotion and Disease Prevention</subject><subject>Heart rate</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Lifestyles</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Minnesota - epidemiology</subject><subject>Obesity</subject><subject>Patient outcomes</subject><subject>Pediatric Obesity - prevention & control</subject><subject>Pediatric Obesity - therapy</subject><subject>Pediatrics</subject><subject>Phentermine</subject><subject>Phentermine - therapeutic use</subject><subject>Public Health</subject><subject>Retrospective Studies</subject><subject>Risk Reduction Behavior</subject><subject>short-communication</subject><subject>Teenagers</subject><subject>Treatment Outcome</subject><subject>Weight control</subject><subject>Weight Loss - drug effects</subject><issn>0307-0565</issn><issn>1476-5497</issn><issn>1476-5497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNksGL1TAQxoso7nP15lkKgnjYPpOmadqLsCyrKyyIoOeQJpM2jzZ5Jq3if--Ut7u8J3uQHAIzv_nyZWay7DUlW0pY88HtwrYktN7Shj_JNrQSdcGrVjzNNoQRURBe87PsRUo7QgjnpHyenZVCCNYyscm-XVsLes6DzfcD-Bni5Dzkwee_wfXDnEcwi54dBpzPVb4H49Qcnb7PT8qrHiYszfXovNMvs2dWjQle3d3n2Y9P19-vborbr5-_XF3eFpo3dC461nZVoytWGWFVp6G0xipe1xqMER0Xpi0VRtGqAq4FaW3NgAugjBtTMnaefTzo7pduAqPRQVSj3Ec3qfhHBuXkaca7Qfbhl-RNS2nJUeD9nUAMPxdIs5xc0jCOykNYksR-tlVDayb-A2WcV4Rxiujbf9BdWKLHTqyCVVOS-pjq1QjSeRvQol5F5SUOkAt8myC1fYTCY2ByOniwDuMnBe-OCgZQ4zykMC7r_NIpeHEAdQwpRbAPfaNErmslca3kulara8TfHPf6Ab7fIwSKA5Aw5XuIR79-TPAvz7jWUg</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Ryder, J R</creator><creator>Kaizer, A</creator><creator>Rudser, K D</creator><creator>Gross, A</creator><creator>Kelly, A S</creator><creator>Fox, C K</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7TK</scope><scope>7TS</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>7U2</scope><scope>5PM</scope></search><sort><creationdate>20170101</creationdate><title>Effect of phentermine on weight reduction in a pediatric weight management clinic</title><author>Ryder, J R ; Kaizer, A ; Rudser, K D ; Gross, A ; Kelly, A S ; Fox, C K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c581t-b39b48c434d7fabce2fdfa566cedd7b57d92ace2277ae5c709f63e57e135dd233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>631/92/436/108</topic><topic>692/308/575</topic><topic>692/699/2743/393</topic><topic>692/700/1720/3187</topic><topic>692/700/2817</topic><topic>Adolescent</topic><topic>Adolescent obesity</topic><topic>Adolescents</topic><topic>Anti-Obesity Agents - 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Academic</collection><collection>Safety Science and Risk</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ryder, J R</au><au>Kaizer, A</au><au>Rudser, K D</au><au>Gross, A</au><au>Kelly, A S</au><au>Fox, C K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of phentermine on weight reduction in a pediatric weight management clinic</atitle><jtitle>International Journal of Obesity</jtitle><stitle>Int J Obes</stitle><addtitle>Int J Obes (Lond)</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>41</volume><issue>1</issue><spage>90</spage><epage>93</epage><pages>90-93</pages><issn>0307-0565</issn><issn>1476-5497</issn><eissn>1476-5497</eissn><abstract>Phentermine is the most widely prescribed obesity medication in adults, yet studies of its use in the pediatric population are limited. We conducted a retrospective chart review of adolescents with obesity treated in a pediatric weight management clinic to examine the weight loss effectiveness of phentermine added to standard of care (SOC) lifestyle modification therapy versus SOC alone. All patients receiving phentermine plus SOC (
n
=25) were matched with a comparison group receiving only SOC (
n
=274). Differences at 1, 3 and 6 months were evaluated using generalized estimated equations adjusting for age, sex and baseline body mass index (BMI) and robust variance standard error estimates for confidence intervals and
P
-values. Phentermine use was associated with a greater percent change in BMI at 1 month (−1.6%; 95% confidence interval (CI): −2.6, −0.6%;
P
=0.001), 3 months (−2.9%; 95% CI: −4.5, −1.4%;
P
<0.001) and 6 months (−4.1%; 95% CI: −7.1, −1.0%;
P
=0.009) compared with SOC alone, with no differences in systolic or diastolic blood pressure between groups. Heart rate was higher at all time-points in the phentermine plus SOC compared with SOC-only group. These data suggest that short-term use of phentermine added to SOC may enhance weight loss in adolescents with obesity in the clinical setting.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>27773937</pmid><doi>10.1038/ijo.2016.185</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; SpringerLink Journals; Nature |
| subjects | 631/92/436/108 692/308/575 692/699/2743/393 692/700/1720/3187 692/700/2817 Adolescent Adolescent obesity Adolescents Anti-Obesity Agents - therapeutic use Behavior Therapy Blood pressure Body mass index Diet, Reducing Drug therapy Epidemiology FDA approval Female Gastrointestinal surgery Health Promotion and Disease Prevention Heart rate Humans Internal Medicine Lifestyles Male Medicine Medicine & Public Health Metabolic Diseases Minnesota - epidemiology Obesity Patient outcomes Pediatric Obesity - prevention & control Pediatric Obesity - therapy Pediatrics Phentermine Phentermine - therapeutic use Public Health Retrospective Studies Risk Reduction Behavior short-communication Teenagers Treatment Outcome Weight control Weight Loss - drug effects |
| title | Effect of phentermine on weight reduction in a pediatric weight management clinic |
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