Evolving artificial metalloenzymes via random mutagenesis

Random mutagenesis has the potential to optimize the efficiency and selectivity of protein catalysts without requiring detailed knowledge of protein structure; however, introducing synthetic metal cofactors complicates the expression and screening of enzyme libraries, and activity arising from free...

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Veröffentlicht in:	Nature chemistry 2018-03, Vol.10 (3), p.318-324
Hauptverfasser:	Yang, Hao, Swartz, Alan M., Park, Hyun June, Srivastava, Poonam, Ellis-Guardiola, Ken, Upp, David M., Lee, Gihoon, Belsare, Ketaki, Gu, Yifan, Zhang, Chen, Moellering, Raymond E., Lewis, Jared C.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/49/1141 631/61/338/469 639/638/77/603 Analytical Chemistry Biochemistry Catalysis Catalysts Chemistry Chemistry/Food Science Cofactors Combinatorial analysis Cyclopropane Enantiomers Inorganic Chemistry Mutagenesis Mutation Organic Chemistry Physical Chemistry Protein structure Proteins Random mutagenesis Selectivity Site-directed mutagenesis
Online-Zugang:	Volltext
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