An association between K65R and HIV-1 subtype C viruses in patients treated with multiple NRTIs

HIV-1 subtype C might have a greater propensity to develop K65R mutations in patients with virological failure compared with other subtypes. However, the strong association between viral subtype and confounding factors such as exposure groups and ethnicity affects the calculation of this propensity....

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2017-07, Vol.72 (7), p.2075-2082
Hauptverfasser:	Smit, Erasmus, White, Ellen, Clark, Duncan, Churchill, Duncan, Zhang, Hongyi, Collins, Simon, Pillay, Deenan, Sabin, Caroline, Nelson, Mark, Winston, Alan, Jose, Sophie, Tostevin, Anna, Dunn, David T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anti-HIV Agents - therapeutic use Antiretroviral Therapy, Highly Active Didanosine - administration & dosage Didanosine - therapeutic use Dideoxynucleosides - administration & dosage Dideoxynucleosides - therapeutic use Drug Resistance, Viral - genetics Female Genetic Association Studies Genotype HIV Infections - drug therapy HIV Infections - virology HIV-1 - classification HIV-1 - drug effects HIV-1 - genetics Humans Male Multivariate Analysis Mutation Original Research Reverse Transcriptase Inhibitors - therapeutic use Sequence Analysis, DNA Stavudine - administration & dosage Stavudine - therapeutic use Tenofovir - administration & dosage Tenofovir - therapeutic use
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